A Conversation with ChatGPT on Contentious Issues in Senescence and Cancer Research
Molecular Pharmacology,
Год журнала:
2024,
Номер
105(5), С. 313 - 327
Опубликована: Март 8, 2024
Artificial
intelligence
(AI)
platforms,
such
as
Generative
Pretrained
Transformer
(ChatGPT),
have
achieved
a
high
degree
of
popularity
within
the
scientific
community
due
to
their
utility
in
providing
evidence-based
reviews
literature.
However,
accuracy
and
reliability
information
output
ability
provide
critical
analysis
literature,
especially
with
respect
highly
controversial
issues,
has
generally
not
been
evaluated.
In
this
work,
we
arranged
question/answer
session
ChatGPT
regarding
several
unresolved
questions
field
cancer
research
relating
therapy-induced
senescence
(TIS),
including
topics
reversibility,
its
connection
tumor
dormancy,
pharmacology
newly
emerging
drug
class
senolytics.
provided
responses
consistent
available
although
occasionally
overlooking
essential
components
current
understanding
role
TIS
biology
treatment.
Although
ChatGPT,
similar
AI
an
accurate
review
outputs
should
still
be
considered
carefully,
issues
biology.
SIGNIFICANCE
STATEMENT
Intelligence
platforms
great
for
researchers
investigate
biomedical
literature
prompt
manner.
arise
when
it
comes
certain
biological
questions,
field.
This
work
discussion
some
yet-to-be-fully-elucidated
conundrums
treatment
highlights
strengths
weaknesses
utilizing
analyzing
on
topic.
Язык: Английский
Therapy-induced senescence is finally escapable, what is next?
Cell Cycle,
Год журнала:
2024,
Номер
23(6), С. 713 - 721
Опубликована: Март 18, 2024
Several
breakthrough
articles
have
recently
confirmed
the
ability
of
tumor
cells
to
escape
stable
cell
cycle
arrest
imposed
by
Therapy-Induced
Senescence
(TIS).
Subsequently,
accepting
hypothesis
that
TIS
is
escapable
should
encourage
serious
reassessments
fundamental
roles
senescence
in
cancer
treatment.
The
potential
for
from
undermines
well-established
suppressor
function
senescence,
proposes
it
as
a
mechanism
dormancy
leading
disease
recurrence
and
invites
further
investigation
its
unfavorable
contribution
therapy
outcomes.
Moreover,
escaping
strongly
indicates
elimination
senescent
cells,
primarily
through
pharmacological
means,
suitable
approach
increasing
efficacy
treatment,
one
still
requires
exploration.
This
commentary
provides
an
overview
recent
evidence
unequivocally
demonstrated
therapy-induced
overcoming
terminal
growth
fate
future
perspectives
on
biology.
Язык: Английский
Can senolysis be used to overcome tumor immune evasion?
Wally Veklych,
Thomas E. Ichim,
Robert Reznik
и другие.
Journal of Stem Cell Research & Therapeutics,
Год журнала:
2024,
Номер
9(1), С. 26 - 32
Опубликована: Янв. 1, 2024
Tumor
escape
from
immunologically
mediated
destruction
is
a
well-studied
phenomena
and
has
been
shown
to
utilize
several
pathways
in
common
with
physiological
conditions
such
as
pregnancy,
well
ocular
or
testicular
immune
privilege.
Recent
interest
senescence
revealed
that
senescent
cells
surrounding
tumors
contribute
development
of
specific
microenvironment
may
allow
for
escape.
Senescent
have
reported
possess
“senescence
associated
secretory
phenotype”
(SASP)
which
produces
inflammatory
agents
directly
indirectly
suppression
T
cell
NK
function.
Exosomes
secreted
by
can
suppress
activation,
downregulate
activity
dendritic
cells,
are
needed
initiation
immunity.
Studies
demonstrated
reduction
load
increases
tumor
sensitivity
variety
therapies.
We
will
overview
supportive
evidence
use
senolytics
potentiate
the
efficacy
immunotherapy
cancer,
discuss
our
preliminary
findings
regarding
SenoVax™
(IND
#30745),
an
autologous,
polyvalent
senolytic
vaccine
being
developed
treatment
advanced
non-small
lung
cancer.
Язык: Английский