Role phosphate-modified cellulose into the scaffold based on poly (glycerol azelaic acid)-co-poly(ε-caprolactone) for using bone regenerative medicine

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140855 - 140855

Опубликована: Фев. 1, 2025

Язык: Английский

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Ph-Responsive Chitosan-Sodium Alginate Nanocarriers for Curcumin Delivery Against Brain Cancer

Опубликована: Янв. 1, 2025

Язык: Английский

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Development of Poly(ether sulfone)/Poly(vinyl alcohol)/Magnesium-Doped Carbon Quantum Dot Scaffolds for Bone Tissue Engineering

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Bone tissue engineering plays a critical role in overcoming the limitations of traditional bone grafts and implants by enhancing integration regeneration. In this study, we developed novel membrane scaffold comprising poly(ether sulfone) (PES), poly(vinyl alcohol) (PVA), magnesium-doped carbon quantum dots (CQDs.Mg) for potential applications. Four distinct formulations (PE-CM0, PE-CM2, PE-CM3, PE-CM4) were using film applicator machine. The morphology porosity scaffolds, characterized via scanning electron microscopy (SEM), revealed increased with higher CQDs.Mg content. Fourier transform infrared spectroscopy (FTIR) confirmed successful functional groups from each component. Water contact angle (WCA) measurements indicated improved hydrophilicity addition CQDs.Mg, which is beneficial cell attachment proliferation. Mechanical testing demonstrated that scaffolds maintained adequate tensile strength flexibility, PE-CM3 PE-CM4 exhibiting superior properties. Swelling assays enhanced water absorption content, while 14-day degradation studies showed excellent structural stability. Biocompatibility was also assessed L929 NIH3T3 lines, cytotoxicity demonstrating nearly 100% viability across all samples. These findings suggest PES/PVA/CQDs.Mg exhibit promising combination mechanical robustness, hydrophilicity, biocompatibility, making them strong candidates

Язык: Английский

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Unlocking the Potential of Cytarabine: A comprehensive Review from Molecular Insights to Advanced Nanoformulations and Co-Delivery Strategies for Enhanced Drug Efficacy

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 102, С. 106346 - 106346

Опубликована: Ноя. 6, 2024

Язык: Английский

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pH-Induced Structural Changes of Crystalline Curcumin Enhance Its Encapsulation in Emulsions

ACS Food Science & Technology, Год журнала: 2024, Номер 4(12), С. 2998 - 3006

Опубликована: Ноя. 18, 2024

The simple and green pH-based method shows promise for encapsulating hydrophobic molecules in delivery systems to enhance their bioavailability. However, there is still a limited understanding of the pH-induced structural changes that are involved. In this study, we combine experimental techniques with molecular dynamics simulations investigate curcumin crystals. An alkali-acid pretreatment was introduced encapsulate curcumin, where first dissolved an alkaline solution then rapidly acidified form aggregates. Remarkably, these aggregates can be spontaneously encapsulated into emulsions, even at high concentrations (1 mg/mL). Microscopy images suggested disrupts crystalline structure curcumin. Molecular further demonstrated hydroxyl groups hydrogen bonds water molecules, while interactions dominate within pH-treated increase solvent-accessible surface area promote rapid solubilization emulsions or milks.

Язык: Английский

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Electrospun lignin-loaded artificial periosteum for bone regeneration and elimination of bacteria

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137149 - 137149

Опубликована: Ноя. 5, 2024

Язык: Английский

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