Journal of Molecular Structure, Год журнала: 2024, Номер 1322, С. 140633 - 140633
Опубликована: Ноя. 6, 2024
Язык: Английский
Journal of Molecular Structure, Год журнала: 2024, Номер 1322, С. 140633 - 140633
Опубликована: Ноя. 6, 2024
Язык: Английский
RSC Advances, Год журнала: 2025, Номер 15(5), С. 3756 - 3828
Опубликована: Янв. 1, 2025
Pyrazolo[1,5- a ]pyrimidines are notable class of heterocyclic compounds with potent protein kinase inhibitor (PKI) activity, playing critical role in targeted cancer therapy.
Язык: Английский
Процитировано
3Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
1Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
Glioblastoma represents the most aggressive type of brain cancer with minimal clinical advancements in recent decades attributed to absence efficient drug delivery strategies. In this study, we synthesized a series vanadium complexes (V1-V4) and then constructed lactoferrin (LF)-V4 nanoparticle (NP) system. The nanoplatform crossed blood-brain barrier by binding low-density lipoprotein receptor-associated protein-1 selectively targeted glioblastoma, ultimately inhibiting growth situ glioblastoma tumors. LF-V4 NPs induced autophagic cell death U87-MG cells generating reactive oxygen species (ROS) that damaged mitochondria. Further studies revealed triggered lipid peroxidation through accumulation ROS, depletion GSH, downregulation GPX4 SLC7A11, leading ferroptosis cells.
Язык: Английский
Процитировано
1Frontiers in Chemistry, Год журнала: 2025, Номер 13
Опубликована: Янв. 30, 2025
In this study, a new MOF (metal-organic framework) based on vanadium and 2,2-bipyridine-4,4-dicarboxylic acid (V/BP-MOF) was synthesized. Synthesized V/BP-MOF introduced as strong adsorbent of Congo Red (CR) an effective agent in eliminating microbial species. the investigation CR absorption activity, several factors such concentration V/BP-MOF, pH, time, temperature were investigated. Antimicrobial evaluations carried out Common bacterial strains wastewater values MIC (minimum inhibitory concentration) MBC (Minimum Bactericidal Concentration) reported. The confirmed characterized by EA, EDS, EDS mapping, FT-IR, XRD, TGA, BET, SEM, TEM. checking characteristics size, specific surface area, thermal stability obtained, respectively, 68 nm, 325 m 2 /g, 320°C. highest adsorption CR, at 94%, obtained natural ambient temperature, after 150 min. kinetic studies, correlation coefficient 0.99 observed with pseudo-second-order model, while isotherm 0.97 Freundlich model. biological evaluations, best inhibition against Escherichia coli , 4 μg/mL μg/mL, respectively. As general result, can be potent absorbent dye antimicrobial properties. Therefore, compound synthesized study suitable option for treatment industry, multiple capabilities including removal chemical pollutants pathogenic agents.
Язык: Английский
Процитировано
0International Journal of Biological Macromolecules, Год журнала: 2025, Номер 301, С. 140472 - 140472
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0The minerals, metals & materials series, Год журнала: 2025, Номер unknown, С. 25 - 39
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0The minerals, metals & materials series, Год журнала: 2025, Номер unknown, С. 21 - 35
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0The minerals, metals & materials series, Год журнала: 2025, Номер unknown, С. 693 - 710
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0The minerals, metals & materials series, Год журнала: 2025, Номер unknown, С. 1021 - 1036
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Next Materials, Год журнала: 2025, Номер 8, С. 100719 - 100719
Опубликована: Май 23, 2025
Язык: Английский
Процитировано
0