Fabrication of chitosan-coated ciprofloxacin drug nanocomposite for combating antibacterial and respiratory infection leading to sepsis
Journal of materials research/Pratt's guide to venture capital sources,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Язык: Английский
Synthesis and Characterization of Silver Nanoparticles-Chitosan Beads as Antibacterial Agents
Jurnal Kimia Sains dan Aplikasi,
Год журнала:
2025,
Номер
28(1), С. 47 - 52
Опубликована: Янв. 30, 2025
One
of
the
key
innovations
in
silver
nanoparticle
(AgNPs)
material
development
is
formation
AgNPs/chitosan
beads,
which
exhibit
enhanced
properties
and
broader
functionality
compared
to
chitosan
or
AgNPs
alone.
In
this
study,
beads
were
synthesized
using
glutaraldehyde
as
a
binding
agent
sodium
citrate
reducing
agent—both
are
safe
non-toxic,
enabling
applications.
The
characterized
assess
their
chemical
physical
properties,
including
functional
groups,
morphology,
crystallinity.
Characterization
results
confirmed
successful
cross-linking
by
glutaraldehyde,
enhancing
material’s
strength.
appeared
white,
while
brownish,
with
an
average
bead
size
1.99
mm.
X-ray
diffraction
analysis
revealed
that
exhibited
face-centered
cubic
crystal
structure.
Antibacterial
testing
demonstrated
superior
antibacterial
activity
attributed
release
Ag+
ions
from
matrix.
Язык: Английский
Construction and Characterization of Polyethylene Glycol/Sodium Alginate Hydrogel Loaded With Zirconia Nanoparticles: Potential Antibacterial and Antibiofilm Agent to Inhibit Dental Caries In Vitro and In Vivo
Layth L. Hamid,
Roqaya S. Zakir,
Nur indah noviyanti Rahman
и другие.
Microscopy Research and Technique,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Biofilm
formation
on
tooth
surfaces
is
a
primary
contributor
to
dental
caries
and
periodontal
diseases.
Streptococcus
mutans
recognized
for
its
role
in
biofilm
production,
significantly
influencing
the
development
of
caries.
Key
virulence
factors
associated
with
S.
biofilms
include
acid
tolerance,
synthesis
exopolysaccharides
(EPS).
This
study
presents
novel
approach
by
focusing
loading
biosynthesized
zirconia
nanoparticles
(ZrO2
NPs)
onto
polyethylene
glycol/sodium
alginate
(PEG/SA)
hydrogel
nanocomposite,
evaluating
their
effects
biofilm-forming
ability
both
vivo
vitro.
ZrO2
NPs
were
using
Citrus
aurantifolia
(C.
aurantifolia)
extract
incorporated
into
PEG/SA
beads
through
sol-gel
process.
The
PEG/SA/ZrO2
nanocomposite
was
confirmed
diverse
analyzes,
including
UV-visible
spectroscopy,
particle
size
measurement,
morphology
examination,
spectral
analysis,
thermal
gravimetric
analysis
(TGA)
hemolysis
studies.
average
approximately
26
nm,
while
exhibited
highly
porous,
sheet-like
surface
structure.
In
vitro
results
demonstrated
inhibition
zones
30
28
mm
against
mutans,
respectively,
minimum
inhibitory
concentration
(MIC)
12.5
mg/mL.
growth
curve
indicated
complete
decline
an
87%
reduction
when
treated
beads.
SEM
revealed
that
cells
appeared
lysed
or
crumpled,
losing
characteristic
coccal
shape
after
exposure
Additionally,
images
effective
prevention
attachment
teeth
encapsulated
hydrogel,
altering
mature
developed
treatment.
Finally,
incorporation
hydrogels
demonstrates
significant
potential
as
strategy
inhibiting
may
serve
promising
topical
agent
reducing
Further
studies
could
explore
long-term
efficacy
clinical
applications
this
oral
health
care.
Язык: Английский
Truffle mediated preparation of bacterial culture medium and mycosynthesis of titanium oxide nanoparticles loaded with polyvinyl alcohol/sodium alginate aerogel beads for antibacterial activity
Layth L. Hamid,
Hanan Hamed,
Abdulbaset Mohammed Al-Fahdawi
и другие.
Journal of Sol-Gel Science and Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 14, 2024
Язык: Английский
Impact of ZnO nanoparticles on MagA gene expression in Klebsiella pneumoniae isolated from diabetic foot ulcers
Asia-Pacific Journal of Molecular Biology and Biotechnology,
Год журнала:
2024,
Номер
unknown, С. 248 - 256
Опубликована: Сен. 26, 2024
Diabetes
mellitus
(DM)
is
an
accumulation
of
glucose
in
the
blood.
Diabetic
divided
into
gestational
diabetes,
type
1
and
2.
Complications
diabetes
include
diabetic
foot
ulcers.
The
most
important
complication
ulcers
bacterial
infection,
which
leads
to
gangrene
when
various
types
antibiotics
fail
prevent
infections.
To
explore
effect
synthetic
zinc
oxide
nanoparticles
(ZnONPs)
on
expression
MagA
gene
Klebsiella
pneumoniae
isolated
from
ulcer
cases.
ZnONPs
were
biosynthesized
by
Aspergillus
niger
characterized
using
scanning
electron
microscopy
(SEM),
Fourier
transform
infrared
(FTIR),
X-ray
diffraction
(XRD),
UV-visible
spectroscopy.
inhibitory
K.
isolates
was
examined
determining
minimum
concentration
(MIC)
ZnONPs.
Besides,
values
before
after
exposure
would
be
RT-qPCR,
with
16SrRNA
as
reference
gene.
According
SEM
XRD
results,
are
form
nanocrystals
have
small
spherical
crystals
average
size
13.5
nm.
highest
optical
density
synthesized
obtained
at
390
exhibit
a
strong
inhibition
zone
against
corresponding
125
μg/mL.
fold
ranged
0.042
0.118.
research
reveals
that
antibacterial
potential
affect
strains.
results
present
study
indicate
can
indeed
used
treatment
infectious
bacteria.
Язык: Английский