Imino-quaternized chitosan/chitosan nanofibers loaded with norfloxacin as potential bandages for wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144304 - 144304

Опубликована: Май 1, 2025

Due to the critical need for effective wound dressings management of burn injuries, this paper focuses on addressing key gaps in infection prevention and control. The study aims develop advanced nanofibrous based quaternized chitosan/chitosan, loaded with norfloxacin modified 2-formylphenylboronic acid enhance antimicrobial antioxidant activity promote healing. materials combine beneficial properties chitosan/quaternized chitosan, such as biocompatibility, biodegradability, activity. characterization was performed from structural (NMR, FTIR, UV-Vis spectroscopy thermogravimetric analysis), morphological (SEM, water vapor sorption) supramolecular points view (X-Ray Diffraction Polarized Microscopy). Essential were evaluated proved excellent performances, Young's modulus up 1250 MPa, swelling capacity till 6 g/g, radical scavenging 70 % enzymatic degradability 53 21 days. fibers presented antibacterial properties, reflected by high inhibition zones against Escherichia coli (40 mm) Staphylococcus aureus (34 antifungal Candida glabrata (15 mm). Preliminary studies demonstrated vitro safety Human Gingival Fibroblasts, while vivo experiments Wistar rats confirmed biocompatibility materials, emphasizing their potential burns.

Язык: Английский

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Ciclopirox-loaded chitosan hydrogel film crosslinked with zinc oxide: a novel sustained-release system for enhanced wound healing and antifungal therapy

Materials Technology, Год журнала: 2025, Номер 40(1)

Опубликована: Май 19, 2025

Язык: Английский

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Non-trivial phase transformations induced by Mn in ZnO nanowires for optoelectronic applications

Journal of Crystal Growth, Год журнала: 2025, Номер unknown, С. 128248 - 128248

Опубликована: Май 1, 2025

Язык: Английский

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