Emerging role of exosomes in cancer therapy: progress and challenges
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Язык: Английский
Leveraging the synergy between anti-angiogenic therapy and immune checkpoint inhibitors to treat digestive system cancers
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 3, 2024
The
response
rates
to
immunotherapy
vary
widely
depending
on
the
type
of
cancer
and
specific
treatment
used
can
be
disappointingly
low
for
many
solid
tumors.
Fortunately,
due
their
complementary
mechanisms
action,
anti-angiogenic
therapy
have
synergistic
effects
in
treatment.
By
normalizing
tumor
vasculature,
improve
blood
flow
oxygenation
facilitate
better
immune
cell
infiltration
into
enhance
effectiveness
immunotherapy.
It
also
reduces
immunosuppressive
factors
enhances
activation,
create
a
more
favorable
environment
cells
attack
tumor.
Their
combination
leverages
strengths
both
therapies
anti-tumor
patient
outcomes.
This
review
discusses
vasculature-immunity
crosstalk
microenvironment
summarizes
latest
advances
combining
checkpoint
inhibitors
treat
digestive
system
Язык: Английский
Angiogenesis as a Survival Mechanism in Heartworm Disease: The Role of Fructose-Bisphosphate Aldolase and Actin from Dirofilaria immitis in an In Vitro Endothelial Model
Animals,
Год журнала:
2024,
Номер
14(23), С. 3371 - 3371
Опубликована: Ноя. 22, 2024
Heartworm
disease,
caused
by
Язык: Английский