Advancing functional foods: a systematic analysis of plant-derived exosome-like nanoparticles and their health-promoting properties
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Март 5, 2025
Plant-derived
exosome-like
nanoparticles
(PDENs),
emerging
as
novel
bioactive
agents,
exhibit
significant
potential
in
food
science
and
nutritional
health.
These
nanoparticles,
enriched
with
plant-specific
biomolecules
such
proteins,
lipids,
nucleic
acids,
secondary
metabolites,
demonstrate
unique
cross-species
regulatory
capabilities,
enabling
interactions
mammalian
cells
gut
microbiota.
PDENs
enhance
nutrient
bioavailability
by
protecting
sensitive
compounds
during
digestion,
modulate
metabolic
pathways
through
miRNA-mediated
gene
regulation,
anti-inflammatory
antioxidant
properties.
For
instance,
grape-derived
reduce
plasma
triglycerides
high-fat
diets,
while
ginger-derived
alleviate
colitis
downregulating
pro-inflammatory
cytokines.
Additionally,
serve
natural
drug
carriers,
applications
delivering
therapeutic
agents
like
doxorubicin
paclitaxel.
Despite
these
advancements,
challenges
remain
standardizing
extraction
methods
(ultracentrifugation,
immunoaffinity),
ensuring
stability
processing
storage,
evaluating
long-term
safety.
Current
research
highlights
the
need
for
optimizing
lyophilization
techniques
understanding
between
matrices.
Furthermore,
show
promise
functional
development—such
fortified
beverages
probiotic
formulations—their
clinical
translation
requires
rigorous
pharmacokinetic
studies
clarity.
This
review
synthesizes
existing
knowledge
on
PDENs’
composition,
biological
activities,
applications,
identifying
gaps
scalability,
stability,
safety
assessments.
Future
directions
emphasize
interdisciplinary
collaboration
to
harness
combating
disorders,
enhancing
functionality,
advancing
personalized
nutrition
strategies.
Язык: Английский
Utilization of Cannabidiol in Post-Organ-Transplant Care
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 699 - 699
Опубликована: Янв. 15, 2025
Cannabidiol
(CBD)
is
one
of
the
major
phytochemical
constituents
cannabis,
Cannabis
sativa,
widely
recognized
for
its
therapeutic
potential.
While
cannabis
has
been
utilized
medicinal
purposes
since
ancient
times,
psychoactive
and
addictive
properties
led
to
prohibition
in
1937,
with
only
medical
use
being
reauthorized
1998.
Unlike
tetrahydrocannabinol
(THC),
CBD
lacks
properties,
yet
name
that
suggests
association
significantly
contributed
public
visibility.
exhibits
diverse
pharmacological
most
notably
anti-inflammatory
effects.
Additionally,
it
interacts
key
drug-metabolizing
enzyme
families,
including
cytochrome
P450
(CYP)
uridine
5′-diphospho-glucuronosyltransferase
(UGT),
which
mediate
phase
I
II
metabolism,
respectively.
By
binding
these
enzymes,
can
inhibit
metabolism
co-administered
drugs,
potentially
enhance
their
toxicity
or
Mild
moderate
adverse
events
associated
have
reported.
Advances
chemical
formulation
techniques
recently
enabled
strategies
minimize
This
review
provides
an
overview
CBD,
covering
historical
background,
recent
clinical
trials,
event
profiles,
interactions
molecular
targets
such
as
receptors,
channels,
enzymes.
We
particularly
emphasize
mechanisms
underlying
effects
interaction
drugs
relevant
organ
transplantation.
Finally,
we
explore
progress
order
bioavailability,
will
enable
decreasing
dose
increase
safety
efficacy.
Язык: Английский
Utility of edible plant-derived exosome-like nanovesicles as a novel delivery platform for vaccine antigen delivery
Vaccine,
Год журнала:
2025,
Номер
52, С. 126902 - 126902
Опубликована: Фев. 26, 2025
Язык: Английский
Exosome-based cancer vaccine: a cell-free approach
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Апрель 24, 2025
Язык: Английский
State-of-the-Art Review on Liposomes as Versatile Cancer Vaccine Delivery Systems
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106975 - 106975
Опубликована: Апрель 1, 2025
Язык: Английский
Plant-based exosome-like extracellular vesicles as encapsulation vehicles for enhanced bioavailability and breast cancer therapy: recent advances and challenges
Medical Oncology,
Год журнала:
2025,
Номер
42(6)
Опубликована: Апрель 28, 2025
Язык: Английский
The Cardioprotective Effect of Ginseng Derived Exosomes via Inhibition of Oxidative Stress and Apoptosis
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
Ginsenosides
possess
potential
protective
effects
against
cisplatin
(CDDP)-induced
toxicity,
but
the
limited
bioavailability
of
ginsenosides
hampered
their
therapeutic
application.
Ginseng
exosomes
(G-Exo),
which
are
active
ingredients
in
ginseng,
exhibit
excellent
biocompatibility
and
low
immunogenicity.
Here,
G-Exo
were
isolated
from
ginseng
roots
through
a
combination
ultracentrifugation
sucrose
gradient
centrifugation
techniques.
Subsequently,
effect
on
CDDP
induced
cardiotoxicity,
its
underlying
mechanisms
explored.
The
findings
demonstrated
that
effectively
mitigated
CDDP-induced
oxidative
stress
apoptosis
Язык: Английский