Cucurbitacins Loaded in Liposome Nanoparticles Inhibit the Development of Lung Cancer Through BECN1-mediated Autophagy DOI
Xiaolin Liu, Peng Diao

Pharmacognosy Magazine, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

Background Autophagy has always been a current research hotspot during lung cancer treatment. Purpose This study aimed to explore the molecular mechanism by which cucurbitacins loaded in liposome nanoparticles (Cu B-NPs) inhibit development of through Beclin 1 (BECN1) regulation. Methods Cu B-NPs were prepared, and A549 group, B group set up assess regulating autophagy inhibiting cancer. B-NPs+si-BECN1 B-NPs+pc-BECN1 also analyze whether regulate BECN1 Results successfully prepared had good dispersion stability. reduced cell viability, promoted apoptosis accumulation autophagosomes, regulated apoptosis-related proteins, thereby development. After activating/inhibiting expression, upregulating Conclusion In this study, particles induced cells BECN1, provides strong evidence clues for further treatment strategies.

Язык: Английский

Lysosomes and LAMPs as Autophagy Drivers of Drug Resistance in Colorectal Cancer DOI Creative Commons
Tsvetomira Ivanova, Yordan Sbirkov,

Maria Kazakova

и другие.

Cells, Год журнала: 2025, Номер 14(8), С. 574 - 574

Опубликована: Апрель 11, 2025

Colorectal cancer (CRC) is among the most malignant pathologies worldwide. A major factor contributing to poor prognosis of neoplastic diseases development drug resistance. It significantly reduces utility therapeutic protocols and necessitates search for novel biomarkers treatment strategies combat cancer. An evolutionarily conserved catabolic mechanism, autophagy maintains nutrient recycling metabolic adaptation also closely related carcinogenesis, playing a dual role. Autophagy inhibition can limit growth tumors improve response therapeutics. Lysosomes, key players in autophagy, are considered promising targets anticancer treatment. There still insufficient data on role poorly studied glycoproteins such as lysosome-associated membrane (LAMPs). They act multifunctional molecules involved multitude processes like development. In current review, we summarize recent double-faceted with focus resistance CRC roles lysosomes LAMPs these interconnected processes. Several lysosomotropic drugs discussed options overcome cell chemoresistance. The complex networks that underline defined autophagic pathways context carcinogenesis especially drivers resistance, outlined.

Язык: Английский

Процитировано

0
DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay DOI

Arpit Sharma,

Shruti S. Raut,

Alok Kumar Shukla

и другие.

Medical Oncology, Год журнала: 2024, Номер 41(11)

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

0
Cucurbitacins Loaded in Liposome Nanoparticles Inhibit the Development of Lung Cancer Through BECN1-mediated Autophagy DOI
Xiaolin Liu, Peng Diao

Pharmacognosy Magazine, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

Background Autophagy has always been a current research hotspot during lung cancer treatment. Purpose This study aimed to explore the molecular mechanism by which cucurbitacins loaded in liposome nanoparticles (Cu B-NPs) inhibit development of through Beclin 1 (BECN1) regulation. Methods Cu B-NPs were prepared, and A549 group, B group set up assess regulating autophagy inhibiting cancer. B-NPs+si-BECN1 B-NPs+pc-BECN1 also analyze whether regulate BECN1 Results successfully prepared had good dispersion stability. reduced cell viability, promoted apoptosis accumulation autophagosomes, regulated apoptosis-related proteins, thereby development. After activating/inhibiting expression, upregulating Conclusion In this study, particles induced cells BECN1, provides strong evidence clues for further treatment strategies.

Язык: Английский

Процитировано

0