Characterization of the Pancreatic Neuroendocrine Neoplasm Immune Microenvironment
Cancer Medicine,
Год журнала:
2025,
Номер
14(7)
Опубликована: Март 27, 2025
A
tumor
is
composed
of
more
than
tumoral
cells.
In
recent
years,
there
has
been
an
increase
in
interest
and
knowledge
the
microenvironment
(TME).
The
TME
integral
part
tumor,
several
cells:
immune,
stromal,
endothelial,
among
others,
thus
offering
a
wide
range
interactions
multiple
possibilities
for
targeted
therapies
environment
modulation.
While
pancreatic
ductal
adenocarcinoma
widely
studied,
it
not
very
true
neuroendocrine
neoplasms
(PNENs).
incidence
PNENs
increasing
and,
therefore,
important
to
comprehend
their
biology
evolution
efficient
since
many
develop
metastasis,
including
G1
PNENs.
This
paper
focuses
on
review
role
Язык: Английский
The mechanism of action and therapeutic potential of tumor-associated macrophages in tumor immune evasion
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 22, 2025
Tumor-associated
macrophages
(TAMs)
play
a
multifaceted
role
in
tumor
progression.
As
specialized
immune
cells,
are
capable
of
phagocytosis
and
digesting
foreign
substances,
as
well
removing
harmful
substances
including
cellular
debris
cells.
Under
specific
pathological
conditions,
circulating
monocytes
can
be
recruited
into
the
microenvironment
differentiate
TAMs.
Macrophages
generally
polarized
two
distinct
subpopulations:
classically
activated
(M1)
alternatively
(M2).
TAMs
constitute
significant
proportion
mononuclear
leukocyte
population
solid
tumors,
exhibiting
complex
dualistic
relationship
with
Substantial
evidence
indicates
that
interact
facilitating
their
evasion
while
promoting
invasion
metastasis.
This
review
focuses
on
mechanism
regulation
response
to
various
macrophage-based
tumor-targeted
therapeutic
strategies.
It
will
provide
reference
for
research
macrophage-centered
therapy
strategies
application
clinical
practice.
Язык: Английский
CSF1-CAR Specifically Targets CSF1R+ Pancreatic Cancer Cells and Tumor-Associated Macrophages
Journal of Immunotherapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 16, 2025
Summary:
A
highly
suppressive
tumor
immune
microenvironment
and
nonspecific
target
endow
malignant
tumors
with
CAR-T
cells.
CSF1R
is
expressed
on
pancreatic
cancer
tissues
compares
normal
in
GEPIA
database
M2
macrophages
mainly
contributing
to
the
(TME),
suggesting
that
a
suitable
antigen.
CSF1
natural
ligand
of
CSF1R,
so
we
constructed
CSF1-CAR
tested
its
cytotoxic
effect
cells
vitro.
Our
results
demonstrated
CSF1-CAR-T
can
lyse
dependent
expression.
Meanwhile,
also
+
macrophages,
play
role
eliminating
remodeling
TME.
Язык: Английский
Updates in Immunotherapy for Pancreatic Cancer
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(21), С. 6419 - 6419
Опубликована: Окт. 26, 2024
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
an
aggressive
malignancy
with
limited
effective
therapeutic
options.
Due
to
a
variety
of
cancer
cell-intrinsic
factors,
including
KRAS
mutations,
chemokine
production,
and
other
mechanisms
that
elicit
dysregulated
host
immune
response,
PDAC
often
characterized
by
poor
infiltration
immune-privileged
fibrotic
stroma.
As
understanding
the
tumor
microenvironment
(TME)
evolves,
novel
therapies
are
being
developed
target
immunosuppressive
mechanisms.
Immune
checkpoint
inhibitors
have
efficacy
when
used
alone
or
radiation.
Combinations
therapies,
along
chemotherapy
chemoradiation,
demonstrated
promise
in
preclinical
early
clinical
trials.
Despite
dismal
response
rates
for
immunotherapy
metastatic
PDAC,
neoadjuvant
somewhat
encouraging,
suggesting
incorporation
treatment
should
be
earlier
disease
course.
Precision
therapy
may
informed
advances
transcriptomic
sequencing
can
identify
immunophenotypes,
allowing
more
appropriate
selection
each
individual
patient.
Personalized
antigen-specific
increasing
topic
interest,
adjuvant
using
personalized
mRNA
vaccines
prevent
recurrence.
Further
development
will
need
balance
precision
generalizability
cost.
Язык: Английский