Study on the mechanism of KIF18B affecting the malignant progression of glioblastoma cells

Frontiers in Genetics, Год журнала: 2025, Номер 16

Опубликована: Март 5, 2025

Member of the driver protein family 18B (KIF18B) is a potential prognostic marker and highly expressed in variety cancers. However, its function glioblastoma (GBM) remains unclear. The expression data KIF18B were obtained by accessing TCGA, CGGA GEPIA databases, verified Western blot assay immunohistochemistry. Glioma RNA sequencing clinical information downloaded from TCGA Kaplan-plotter survival analysis Multivariable COX regression performed to plot ROC curves at 1, 3 5 years cBioPortal MethSurv used carefully examine value methylation. CBioPortal database UALCAN obtain co-expressed genes for GO KEGG enrichment analysis, gene set (GSEA) software was explore signaling pathway regulation GBM. Finally, correlation between GBM infiltration studied using TIMER dataset. various cancers including GBM, positively correlated with glioma grade negatively prognosis. curve showed that one independent risk factors methylation expression, overall rate patients hypomethylation lower than hypermethylation. A total 124 selected database. mainly involved malignant progression through P53 other pathways. GSEA high group enriched E2F, G2M results immunoassay immune tumor microenvironment. key factor affecting prognosis patients, targeting may provide new therapeutic method patients.

Язык: Английский

Research Progress of KIF18B in Cancer at Present

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(04), С. 1711 - 1719

Опубликована: Янв. 1, 2025

Язык: Английский

KIF18B drives the malignant progression of gliomas by activating the Notch pathway

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111888 - 111888

Опубликована: Май 1, 2025

Язык: Английский