Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Май 16, 2025
Язык: Английский
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Фев. 3, 2025
Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers promising alternative, leveraging its immunomodulatory, neuroprotective, regenerative capabilities. This review provides an in-depth analysis MSC mechanisms action, including regulation, promotion remyelination, neuroregeneration. It examines preclinical studies trials evaluating efficacy, safety, limitations in various MS phenotypes. Special attention given challenges delivery routes, dosing regimens, integrating MSCs with conventional therapies. By highlighting advancements ongoing challenges, this underscores potential revolutionize treatment, paving way for personalized combinatory therapeutic approaches.
Язык: Английский
Процитировано
2
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Март 26, 2025
Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.
Язык: Английский
Процитировано
1
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15
Опубликована: Март 18, 2025
Antibiotics represent one of the most significant medical breakthroughs twentieth century, playing a critical role in combating bacterial infections. However, rapid emergence antibiotic resistance has become major global health crisis, significantly complicating treatment protocols. This paper provides narrative review current state resistance, synthesizing findings from primary research and comprehensive articles to examine various mechanisms bacteria employ counteract antibiotics. One sources is improper use antibiotics livestock industry. The drug-resistant microorganisms human activities industrial production presented environmental public concerns. Today, resistant nosocomial infections occur following long-term hospitalization patients, causing death many people, so there an urgent need for alternative treatments. In response this non-antibiotic therapeutic strategies have been proposed, including bacteriophages, probiotics, postbiotics, synbiotics, fecal microbiota transplantation (FMT), nanoparticles (NPs), antimicrobial peptides (AMPs), antibodies, traditional medicines, toxin-antitoxin (TA) system. While these approaches offer innovative solutions addressing preserving efficacy therapies, challenges such as safety, cost-effectiveness, regulatory hurdles, large-scale implementation remain. examines potential limitations strategies, offering balanced perspective on their managing mitigating broader impact resistance.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 1, 2025
There is a widespread distribution of gram-negative bacteria worldwide, which are responsible for the deaths numerous patients each year. The illnesses they cause can be localized and systemic, these possess several key virulence factors that contribute to their pathogenicity. In recent years, distinct mechanisms pathogenesis have evolved remain largely unknown scientists medical experts. Among these, outer membrane vesicles (OMVs) undoubtedly one most significant influencing virulence. OMVs contain various bacterial compounds diverse effects on host organisms immune system, potentially exacerbating disease inflammation while evading responses. This review comprehensively examines role in pathogenesis, interaction with cells, potential biomedical applications. Understanding molecular governing OMV biogenesis function could pave way novel antimicrobial strategies therapeutic interventions.
Язык: Английский
Процитировано
0
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Апрель 29, 2025
Batch-to-batch inconsistencies and time-intensive protocols remain significant challenges in conventional nanomaterial synthesis. Here, we present an automated system that precisely fabricates silica-coated gold nanostars (AuNS@SiO2) incorporating Raman reporters (4-MBA IR-780) defined as nanotags, thereby enabling control over their morphological, optical, spectroscopic properties. The resulting nanotags were comprehensively characterized through UV-vis spectrophotometry, transmission electron microscopy (TEM), surface enhanced (resonance) spectroscopy (SE(R)RS) measurements, dynamic light scattering (DLS), zeta potential analyzes. Compared to manual methods, our approach demonstrated higher reproducibility both synthesis the properties of produced nanotags. Additionally, underscore sensing applications, functionalized with streptavidin. By combining precise robust characterization, this work establishes a new standard for rapid reliable production advanced nanoplatforms biomedical applications.
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Май 13, 2025
Cancer is a complex and heterogeneous disease that often requires multifaceted treatment strategies to achieve optimal therapeutic outcomes. Given the limitations of single-agent therapies, particularly in face intricate biological signaling networks resistance, there growing need for combinatory approaches. This article presents novel hypothesis: simultaneous use ribosome-inactivating proteins (RIPs) mesenchymal stem cells (MSCs) or MSC-derived extracellular vesicles (EVs) cancer treatment. RIPs, with their potent cytotoxic properties, can target tumor effectively, while MSCs, known tumor-homing abilities regenerative potential, serve as delivery vehicles, potentially enhancing targeting precision reducing systemic toxicity RIPs. hypothesis explores synergistic potential combining these two modalities, leveraging advantages both techniques create more effective strategy. By RIPs’ ability inhibit protein synthesis MSCs EVs’ capability modulate microenvironment deliver agents. approach offers promising avenue overcoming cancer’s inherent complexity. However, challenges remain, such optimizing dosing protocols, addressing safety concerns, ensuring efficient drug delivery. Future research clinical trials are necessary validate this combination viable therapy.
Язык: Английский
Процитировано
0
Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown
Опубликована: Май 16, 2025
Язык: Английский
Процитировано
0