Enhancing S-nitrosoglutathione Reductase Decreases S-Nitrosylation of ERO1α and Reduces Neuronal Death in Secondary Traumatic Brain Injury DOI
Guangjie Liu, Dengfeng Lu, Jie Wu

и другие.

Nitric Oxide, Год журнала: 2024, Номер 154, С. 29 - 41

Опубликована: Ноя. 19, 2024

Язык: Английский

10% carbon dioxide improves cognitive function after subarachnoid hemorrhage in rats: inhibiting neuronal apoptosis through the PI3K/AKT signaling pathway DOI Creative Commons

Liuyang Tang,

Daochen Wen,

Zichao Huang

и другие.

Medical Gas Research, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Many patients experience long-term cognitive dysfunction after subarachnoid hemorrhage (SAH), and effective treatments are currently lacking. Carbon dioxide (CO 2 ), an inexpensive easily produced gas, forms carbonic acid when dissolved in water. Studies have suggested that hypercapnia may neuroprotective effects. However, the optimal concentration of CO for therapeutic inhalation is still unclear. This study aimed to investigate effects various concentrations on function SAH rats explore potential molecular mechanisms involved. In this study, we established a rat model by endovascular perforation internal carotid artery. The models inhaled at 10%, 20%, or 30%, 1 hour modeling. results showed 10% improved cortical blood flow following SAH, while higher (20% 30%) worsened hypoperfusion. partial pressure did not change but it significantly increased with . Additionally, effectively inhibited neuronal apoptosis, enhanced locomotor activity, memory learning abilities rats. Moreover, upregulated phosphorylation phosphatidylinositol 3 kinase) protein kinase B, expression Bcl-2, decreased Bax. conclusion, inhaling restores cerebral perfusion, inhibits improves contrast, led effect occur through activation 3-kinase/protein B signaling pathway.

Язык: Английский

Процитировано

0
Icariin attenuates oxidative stress via SIRT1/PGC-1α pathway in SAH mice DOI

Xingwei Lei,

Daochen Wen,

Zichao Huang

и другие.

Experimental Neurology, Год журнала: 2025, Номер 390, С. 115303 - 115303

Опубликована: Май 8, 2025

Язык: Английский

Процитировано

0
Differential efficacy of remote ischaemic conditioning in anterior versus posterior circulation stroke: A prespecified secondary analysis of the RICAMIS trial DOI Creative Commons
Xinyu Shen,

Ying‐Jie Dai,

Thanh N. Nguyen

и другие.

European Journal of Neurology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

The benefit of remote ischaemic conditioning (RIC) in acute moderate stroke has been demonstrated by the Remote Ischaemic Conditioning for Acute Moderate Stroke (RICAMIS) study. This prespecified exploratory analysis aimed to determine whether there was a difference RIC efficacy anterior versus posterior circulation based on RICAMIS data.

Язык: Английский

Процитировано

0
Enhancing S-nitrosoglutathione Reductase Decreases S-Nitrosylation of ERO1α and Reduces Neuronal Death in Secondary Traumatic Brain Injury DOI
Guangjie Liu, Dengfeng Lu, Jie Wu

и другие.

Nitric Oxide, Год журнала: 2024, Номер 154, С. 29 - 41

Опубликована: Ноя. 19, 2024

Язык: Английский

Процитировано

0