Research Progress on the Mechanism of Hemorrhage Transformation in Ischemic Stroke DOI Open Access

月丽 蔡

Journal of Clinical Personalized Medicine, Год журнала: 2024, Номер 03(04), С. 1611 - 1618

Опубликована: Янв. 1, 2024

Язык: Английский

Oridonin Alleviates Cerebral Ischemic-Reperfusion (I/R) Injury by Covalently Binding with Hmgb1 and Inhibiting Hmgb1/Tlr4/Myd88/Nf-Κb Signaling Pathway DOI
Dandan Liu, Shujie Zhang,

Qiaoli Shi

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Revolutionizing Neuroimmunology: Unraveling Immune Dynamics and Therapeutic Innovations in CNS Disorders DOI Open Access
Corneliu Toader,

Călin Petru Tătaru,

Octavian Munteanu

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13614 - 13614

Опубликована: Дек. 19, 2024

Neuroimmunology is reshaping the understanding of central nervous system (CNS), revealing it as an active immune organ rather than isolated structure. This review delves into unprecedented discoveries transforming field, including emerging roles microglia, astrocytes, and blood–brain barrier (BBB) in orchestrating neuroimmune dynamics. Highlighting their dual both repair disease progression, we uncover how these elements contribute to intricate pathophysiology neurodegenerative diseases, cerebrovascular conditions, CNS tumors. Novel insights microglial priming, astrocytic cytokine networks, meningeal lymphatics challenge conventional paradigms privilege, offering fresh perspectives on mechanisms. work introduces groundbreaking therapeutic innovations, from precision immunotherapies controlled modulation BBB using nanotechnology focused ultrasound. Moreover, explore fusion with neuromodulatory technologies, underscoring new frontiers for personalized medicine previously intractable diseases. By synthesizing advancements, propose a transformative framework that integrates cutting-edge research clinical translation, charting bold path toward redefining management era neuroimmunology.

Язык: Английский

Процитировано

3
Elevated Serum HMGB1 Levels and Their Association with Recurrence of Acute Ischaemic Stroke DOI Creative Commons

Liping Shen,

Jiangsheng Yang,

Zufu Zhu

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 6887 - 6894

Опубликована: Сен. 1, 2024

Purpose:The study aimed to investigate the correlation between baseline serum levels of high mobility group box 1 (HMGB1) and recurrence acute ischemic stroke (AIS).Patients Methods: A total 544 AIS patients were enrolled followed up monthly.Serum HMGB1 measured using enzyme-linked immunosorbent assay (ELISA).The primary endpoint was first AIS.Results: During a median follow-up period 43 months, 62 experienced recurrence.Both national institute health scale (NIHSS) scores significantly higher in compared norecurrence (p<0.05).According receiver operating characteristic curve analysis, combination (0.855, 95% CI: 0.800-0.911) (0.745, 0.663-0.826)and NIHSS (0.822, 0.758-0.886)had value for predicting than either them (p<0.05).Kaplan-Meier analyses demonstrated that cumulative survival without lower level low (p<0.05).The multifactorial Cox indicated elevated (HR: 7.489, CI:4.383-12.795)were highly effective predictor AIS.Conclusion: Elevated found be AIS.

Язык: Английский

Процитировано

2
Paeoniflorin regulates microglia-astrocyte crosstalk, inhibits inflammatory response, and alleviates neuropathic pain through HSP90AA1/HMGB1 signaling pathway DOI

Feng-Qin Luo,

Juan Zhang,

Y. Miao

и другие.

The International Journal of Biochemistry & Cell Biology, Год журнала: 2024, Номер 176, С. 106675 - 106675

Опубликована: Окт. 11, 2024

Язык: Английский

Процитировано

2
Multifaceted role of HMGB1: From nuclear functions to cytoplasmic and extracellular signaling in inflammation and cancer—Review DOI

Desislava Vladimirova,

Sonya Staneva,

Iva Ugrinova

и другие.

Advances in protein chemistry and structural biology, Год журнала: 2024, Номер unknown, С. 271 - 300

Опубликована: Окт. 30, 2024

Язык: Английский

Процитировано

2
The intervention mechanism of Tanshinone IIA in alleviating neuronal injury induced by HMGB1 or TNF-α-mediated microglial activation DOI

Yan-Zhu Quan,

Jinghe Wang, Sihui Zhang

и другие.

Toxicology in Vitro, Год журнала: 2024, Номер unknown, С. 105950 - 105950

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1
Potential and Challenges of Transcranial Photobiomodulation for the Treatment of Stroke DOI Creative Commons
Siyue Li, Thomson W. L. Wong, Shamay S. M. Ng

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(12)

Опубликована: Дек. 1, 2024

ABSTRACT Photobiomodulation (PBM), also known as low‐level laser therapy, employs red or near‐infrared light emitted from a light‐emitting diode for the treatment of various conditions. Transcranial PBM (tPBM) is form that delivered to head improve brain health, tPBM enhances mitochondrial function, improves antioxidant responses, reduces inflammation, offers protection apoptosis, blood flow, increases cellular energy production, and promotes neurogenesis neuroplasticity. As such, holds promise stroke. This review summarizes recent findings on stroke, presenting evidence both animal studies clinical trials demonstrate its efficacy. Additionally, it discusses potential challenges encountered in translation process. Furthermore, proposes new technologies directions development light‐delivery methods emphasizes need extensive validate widen application future treatments

Язык: Английский

Процитировано

1
Research Progress on the Mechanism of Hemorrhage Transformation in Ischemic Stroke DOI Open Access

月丽 蔡

Journal of Clinical Personalized Medicine, Год журнала: 2024, Номер 03(04), С. 1611 - 1618

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0