Artificial intelligence in ovarian cancer drug resistance advanced 3PM approach: subtype classification and prognostic modeling
The EPMA Journal,
Год журнала:
2024,
Номер
15(3), С. 525 - 544
Опубликована: Июль 13, 2024
Язык: Английский
Genetic Manipulation in Agriculture
Опубликована: Янв. 1, 2025
Characterization of the gut microbiota in drug abuse: prediction, prevention, and personalized medicine to benefit affected populations
The EPMA Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 15, 2025
Язык: Английский
Pyruvate Kinase M1/2 Proteoformics for Accurate Insights into Energy Metabolism Abnormity to Promote the Overall Management of Ovarian Cancer Towards Predictive, Preventive, and Personalized Medicine Approaches
Yan Wang,
Nuo Xu,
Marie Louise Ndzie Noah
и другие.
Metabolites,
Год журнала:
2025,
Номер
15(3), С. 203 - 203
Опубликована: Март 16, 2025
Ovarian
cancer
(OC)
is
a
global
health
problem
that
frequently
presents
at
advanced
stages,
predisposed
to
recurrence,
readily
develops
resistance
platinum-based
drugs,
and
has
low
survival
rate.
Predictive,
preventive,
personalized
medicine
(PPPM/3PM)
offers
an
integrated
solution
with
the
use
of
genetic,
proteomic,
metabolic
biomarkers
identify
high-risk
individuals
for
early
detection.
Metabolic
reprogramming
one
key
strategies
employed
by
tumor
cells
adapt
microenvironment
support
unlimited
proliferation.
Pyruvate
kinases
M1
M2
(PKM1/2)
are
encoded
PKM
gene,
pivotal
enzyme
in
last
step
glycolytic
pathway,
which
crossroads
aerobic
oxidation
Warburg
effect
serve
as
potential
regulator
glucose
metabolism
influence
cellular
energy
production
reprogramming.
Commonly,
ratio
PKM1-to-PKM2
changed
tumors
compared
normal
controls,
PKM2
highly
expressed
OC
induce
high
glycolysis
rate
participate
malignant
invasion
metastatic
characteristics
epithelial/mesenchymal
transition
(EMT).
inhibitors
suppress
migration
growth
interfering
effect.
Proteoforms
final
structural
functional
forms
gene/protein,
canonical
protein
contains
all
proteoforms
same
gene.
The
complexity
can
be
elucidated
proteoformics.
OC-specific
proteoform
might
represent
specific
target
therapeutic
interventions
against
OC.
In
framework
PPPM/3PM,
warning
prognosis
biomarker.
It
important
clarify
molecular
mechanisms
metabolism.
This
review
analyzes
expression,
function,
OC,
help
Язык: Английский
IgG N-glycosylation contributes to different severities of insulin resistance: implications for 3P medical approaches
The EPMA Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Язык: Английский
Evolucollateral dynamics in stroke: Evolutionary pathophysiology, remodelling and emerging therapeutic strategies
European Journal of Neuroscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
Leptomeningeal
collaterals
(LMCs)
are
crucial
in
mitigating
the
impact
of
acute
ischemic
stroke
(AIS)
by
providing
alternate
blood
flow
routes
when
primary
arteries
obstructed.
This
article
explores
evolutionary
pathophysiology
LMCs,
highlighting
their
critical
function
and
genetic
molecular
mechanisms
governing
development
remodelling.
We
address
translational
challenges
applying
animal
model
findings
to
human
clinical
scenarios,
emphasizing
need
for
further
research
validate
emerging
therapies—such
as
pharmacological
agents,
gene
therapy
mechanical
interventions—in
settings,
aimed
at
enhancing
collateral
perfusion.
Computational
modelling
emerges
a
promising
method
integrating
experimental
data,
which
requires
precise
parameterization
empirical
validation.
introduce
‘Evolucollateral
Dynamics’
hypothesis,
proposing
novel
framework
that
incorporates
biology
principles
into
therapeutic
strategies,
offering
new
perspectives
on
circulation.
hypothesis
emphasizes
role
predispositions
environmental
influences
circulation,
may
strategies
optimize
treatment
outcomes.
Future
must
incorporate
data
create
robust
protocols,
thereby
maximizing
potential
LMCs
improving
outcomes
patients.
Язык: Английский
Synergies between diabetes and hyperhomocysteinaemia: New insights to predict and prevent adverse cardiovascular effects
Diabetes Obesity and Metabolism,
Год журнала:
2024,
Номер
26(12), С. 5776 - 5785
Опубликована: Окт. 21, 2024
To
explore
the
association
of
hyperhomocysteinaemia
(HHcy)
and
diabetes
synergies
with
cardiovascular
events
in
adult
population
northern
China.
Язык: Английский
Observational and genetic associations between cardiorespiratory fitness and age-related diseases: longitudinal analyses in the UK Biobank study
The EPMA Journal,
Год журнала:
2024,
Номер
15(4), С. 629 - 641
Опубликована: Ноя. 6, 2024
Язык: Английский
A Paradigm Shift on Emergence of Pharmacogenomics in the Era of Personalized Medicine
Advances in medical technologies and clinical practice book series,
Год журнала:
2024,
Номер
unknown, С. 1 - 34
Опубликована: Дек. 13, 2024
Pharmacogenomics
is
the
study
of
genetic
modifications
in
patients
that
influence
their
potential
to
metabolize
medications,
encouraging
tolerability
and
desired
effect.
Genetic
(like
genome-wide
association
&
candidate
gene)
methods
may
help
choosing
most
suitable
drug
dosage,
by
impeding
adverse
reactions
(ADRs).
are
usually
documented
as
key
steps
personalized
medicine.
The
significance
medicine
healthcare
developing
due
its
defined
molecular
basis.
Personalized
anticipates
beneficial
or
serious
side
effects
a
medication
using
specific
individual's
profile.
In
recent
year's
pharmacogenomics
approaches
being
widely
used
personalizing
therapies
for
diseases
like
Cancer,
Rheumatoid
arthritis,
Asthma,
Type-1
diabetes
many
psychiatric
disorders
(depression,
psychosis,
schizophrenia
etc.).This
chapter
provides
an
overview
present
importance
identifies
challenges
need
be
conquered
effective
Язык: Английский