The EPMA Journal, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
Язык: Английский
The EPMA Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Association of both intrinsic and extrinsic risk factors leading to accelerated skin ageing is reflected in excessive ROS production ir/reversible mitochondrial injury burnout, as abundantly demonstrated by accumulating research data. Due the critical role stress pathophysiology disorders, maintained (primary care) restored (secondary health, rejuvenation homoeostasis are considered most effective holistic approach advance dermatological treatments based on systemic health-supportive stimulating measures. Per evidence, an anti-ageing protection, wound healing scarring quality - all strongly depend sustainable functionality well-balanced homoeostasis. The latter can be objectively measured and, if necessary, a manner pre- rehabilitation algorithms tailored individualised patient profiles. entire spectrum corresponding innovations area includes natural rejuvenation, aesthetic reconstructive medicine, protection targeted disorders. Contextually, mitochondria-centric dermatology instrumental for advanced 3PM-guided which makes good use predictive multi-level diagnostics against health-to-disease transition progression relevant Cost-effective new treatment avenues focused health physiologic proposed article including in-depth analysis cases exemplified care with detailed mechanisms expert recommendations presented.
Язык: Английский
Процитировано
2
The EPMA Journal, Год журнала: 2024, Номер 15(4), С. 559 - 571
Опубликована: Ноя. 20, 2024
Breast cancer belongs to the most commonly diagnosed malignancies worldwide, with its increasing incidence paralleled by advances in early diagnostics and effective treatments resulting significantly improved survival rates. However, breast survivors often experience reduced quality of life linked long-term health burden as a consequence aggressive oncological applied. Their frequently recorded complains include chronic fatigue, physical activity, disordered sleep, chronification pain, severe mental impairments-all per evidence are associated compromised mitochondrial impaired homeostasis. Self-report survivor is included this article illustrate currently uncovered patient needs. This highlights mechanisms behind suboptimal damage, introduces novel, mitochondria-based holistic approach addressing rehabilitation concepts for following advanced principles predictive, preventive personalised medicine (3PM). By operating via function, proposed triggers systemic effects at molecular, sub/cellular organismal levels positively affecting energy metabolism, repair well creating, therefore, highly algorithms tailored an individualised profile. The methodology integrates assessments utilising homeostasis biomarkers tear fluid non-invasive diagnostic tool, nutraceuticals lifestyle adjustments. introduced aligns 3PM, offering proactive framework managing persistent post-treatment symptoms cohort survivors. Furthermore, presented also applicable pre-habilitation programmes considering needs other cohorts affected diseases such CVD orthopaedic disorders planned major surgical incisions, who require individually adapted pre- programmes. Implementing innovative strategies may lead full recovery, sustainable conditions and, facilitating patients' comeback normal daily activities, family professional life. Contextually, considered 'proof-of-principle' model 3PM-related paradigm shift from reactive cost-effective management both primary secondary care benefiting large spectrum cohorts, individuals society large.
Язык: Английский
Процитировано
6
Journal of Stroke and Cerebrovascular Diseases, Год журнала: 2025, Номер unknown, С. 108285 - 108285
Опубликована: Март 1, 2025
ObjectivePatients with chronic kidney disease (CKD) exhibit a disproportionately elevated risk of stroke, frequently compounded by renal impairment. Therapeutic strategies for stroke based on Traditional Chinese Medicine's 'kidney–brain axis' theory demonstrate clinical efficacy, indicating that there may be potential association between and which needs further exploration verification.MethodsIn this study, databases such as GEO, NHANES, GWAS were used to collect data related CKD stroke. GEO gene enrichment analysis was explore possible mediating factors NHANES verify the results. Mendelian randomization confirm causal relationship effect in these two diseases.ResultsCross-gene transcription factor revealed lipid-related pathways have Logistic regression changes LDL-C, HDL-C, TC, TG can affect occurrence determine verified effects lipid factors, TG, diseases. Our findings highlight relevance bridging By integrating predictive biomarkers multi-level diagnostics, study paves way AI-driven precision medicine prevention. Specifically, machine learning approaches could enhance stratification high-risk cohorts, enabling tailored interventions lipid-lowering therapies personalized monitoring protocols. These align emerging paradigms healthcare benefits population-specific management.ConclusionThis provides new insights into interactive scientific basis process syndrome differentiation treatment under guidance "kidney–brain correlation". Moreover, influence metabolism diseases investigated, deepened researchers' understanding mechanism
Язык: Английский
Процитировано
0
The EPMA Journal, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
Abstract Background Acute mountain sickness (AMS) is a self-limiting illness, involving complex series of physiological responses to rapid ascent high altitudes, where the body exposed lower oxygen levels (hypoxia) and changes in atmospheric pressure. AMS mildest most common form altitude sickness; however, without adequate preparation adherence guidelines, it can progress life-threatening conditions. Aims Due multi-factorial predisposition among individuals, identifying biomarkers before exposure from multiple dimensions (e.g., clinical, metabolic, proteomic markers) integrating them build an predictive model enables early diagnosis personalized interventions, which allows targeted allocation medical resources, such as prophylactic medications acetazolamide) supplemental oxygen, those who need prevention unnecessary complications. Consequently, predicting utilizing multidimensional phenotypic data high-altitude essential for paradigm change research currently applied reactive services cost-effective predictive, preventive, medicine (PPPM/3PM) primary (reversible damage health protection against health-to-disease transition) secondary (personalized disease progression) care. Methods To this end, study recruited 83 Han Chinese male volunteers obtained proteomic, metabolomic profiles analysis they ascended altitudes. The Mann–Whitney U test was used identify clinical features distinguishing non-AMS. were concatenated clustered find co-expression modules associated with AMS. A machine learning model, Mutual Information-radial kernel-based Support Vector Machine-Recursive Feature Elimination (MI-radialSVM-RFE) employed selection prediction. molecular docking technique select that bind Traditional Medicine (TCM) ingredients. Results Among participants, 66 selected detailed after quality control steps. Six protein-metabolite identified significantly MI-radialSVM-RFE 12 (two features: systolic blood pressure (SBP) peak expiratory flow (PEF); six proteins: Acyl-CoA synthetase long-chain family member 4 (ACSL4), immunoglobulin kappa variable 1D-16 (IGKV1D-16), coagulation factor XIII B subunit (F13B), prosaposin (PSAP), poliovirus receptor (PVR), multimerin-2 (MMRN2); four metabolites: 2-Methyl-1,3-cyclohexadiene, calcitriol, 4-Acetamido-2-amino-6-nitrotoluene, 20-Hydroxy-PGE2) prediction model. exhibited excellent performance both training ( n = 66) validating cohorts 24) AUCs 0.97 0.94, respectively. Additionally, suggested PSAP ACSL4 proteins potential targets prevention. Conclusion expert recommendations This advances by developing using data. linked energy metabolism, immune response, vascular regulation offer insights into mechanisms. High-altitude approaches should focus on implementing biomarker-driven risk screening high-risk individuals exposure. Preventive measures prioritize pre-acclimatization protocols, tailored nutritional strategies interventions guided biomarker profiles, lifestyle adjustments, maintaining mitochondrial through proper strategies.
Язык: Английский
Процитировано
0
Talanta, Год журнала: 2025, Номер unknown, С. 128029 - 128029
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
The EPMA Journal, Год журнала: 2025, Номер unknown
Опубликована: Апрель 15, 2025
Abstract Mitochondria are the primary sites for aerobic respiration and play a vital role in maintaining physiologic function at cellular organismal levels. Physiologic mitochondrial homeostasis, functions, health, any kind of impairments associated with systemic effects that linked to human health pathologies. Contextually, mitochondria acting as natural biosensor humans controlling status physical mental holistic manner. So far, no disorder is known happening independently from compromised cause (primary dysfunction) or target collateral damage (secondary injury). This certainty makes medicine be superior instrument reach highly ambitious objectives predictive, preventive, personalized (PPPM/3PM). 3PM effectively implements paradigm change economically ineffective reactive medical services predictive approach, targeted prevention treatments tailored individualized patient profiles (protection against health-to-disease transition) secondary disease progression) healthcare. Mitochondrial DNA (mtDNA) properties differ significantly those nuclear (nDNA). For example, mtDNA cell-free molecule much more stable compared nDNA, which an attractive diagnostic circulating body fluids such blood tear fluid. Further, genetic variations contribute substantial individual differences susceptibility treatment response. To this end, current gene editing technologies, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas, still immature modification, cannot applied clinical practice posing challenge mtDNA-based therapies. In contrast, comprehensive multiomics technologies offer new insights into enables develop effective multi-level diagnostics strategies. review article highlights health- disease-relevant particularities assesses involvement implementing objectives. By discussing interrelationship between medicine, we aim provide foundation advancing early diagnostics, cost-effective care, exemplify creating proof-of-concept approaches 3PM-guided applications.
Язык: Английский
Процитировано
0
The EPMA Journal, Год журнала: 2024, Номер 15(4), С. 599 - 610
Опубликована: Ноя. 19, 2024
Язык: Английский
Процитировано
1
The EPMA Journal, Год журнала: 2024, Номер unknown
Опубликована: Дек. 23, 2024
Язык: Английский
Процитировано
0