Health Affairs Scholar,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 16, 2024
Abstract
Cannabis
legalization
continues
to
spread,
with
38
states
permitting
use
of
medical
marijuana,
22
recreational
use,
and
growing
political
momentum
for
federal
legalization.
The
last
time
FDA
was
tasked
regulating
a
new
product
occurred
2009’s
Family
Smoking
Prevention
Tobacco
Control
Act,
which
created
the
Center
Products
(CTP).
Thus,
is
ripe
review
history
CTP
particular
attention
difficulties
nascent
center
faced
in
novel
products
such
as
e-cigarettes
or
Electronic
Nicotine
Delivery
Systems
(ENDS).
Specifically,
has
struggled
defining
its
scope
authority,
determining
pathway(s)
utilize,
promulgating
timely
transparent
standards
marketing
authorization
–
all
offer
lessons
improving
cannabis
oversight
enforcement.
Frontiers in Toxicology,
Год журнала:
2024,
Номер
6
Опубликована: Май 9, 2024
Introduction
The
association
between
Δ8-tetrahydrocannabinol
(THC)
and
cardiac
dysrhythmia
has
not
been
well
described
in
children.
Asystole,
while
consistent
with
reports
of
severe
bradycardia
apnea
children,
is
uncommonly
the
current
literature.
We
present
first
pediatric
case
asystole
following
THC
ingestion.
Case
A
7-year-old
male
presented
to
emergency
department
(ED)
after
his
mother
noticed
he
was
lethargic
3–4
h
accidental
ingestion
five
15
mg
(total
75
mg)
Δ8-THC
gummies.
Upon
arrival,
vitally
stable
well-appearing.
He
received
maintenance
intravenous
fluids.
Approximately
7
initial
ingestion,
experienced
a
>15-s
episode
on
telemetry
requiring
sternal
rub
awaken.
This
followed
by
(60
beats
per
minute
range)
which
resolved
0.1
glycopyrrolate.
admitted
PICU,
drowsy
but
arousable
vitals.
After
an
uneventful
24-h
(post-ingestion)
PICU
observation,
discharged
home
condition.
Discussion
To
our
knowledge,
this
reported
THC-induced
asystole.
etiology
may
be
attributed
direct
vagal
stimulation
or
respiratory
depression.
typical
recommended
observation
time
potential
toxicity
3–6
children
have
returned
their
physiological
behavioral
baseline.
Our
patient
clinically
no
concern
for
depression
yet
asystolic
pause
Conclusion
demonstrates
that
occur
patients
large
ingestions
those
symptoms
can
appear
late
outside
currently
period.
Health Affairs Scholar,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 16, 2024
Abstract
Cannabis
legalization
continues
to
spread,
with
38
states
permitting
use
of
medical
marijuana,
22
recreational
use,
and
growing
political
momentum
for
federal
legalization.
The
last
time
FDA
was
tasked
regulating
a
new
product
occurred
2009’s
Family
Smoking
Prevention
Tobacco
Control
Act,
which
created
the
Center
Products
(CTP).
Thus,
is
ripe
review
history
CTP
particular
attention
difficulties
nascent
center
faced
in
novel
products
such
as
e-cigarettes
or
Electronic
Nicotine
Delivery
Systems
(ENDS).
Specifically,
has
struggled
defining
its
scope
authority,
determining
pathway(s)
utilize,
promulgating
timely
transparent
standards
marketing
authorization
–
all
offer
lessons
improving
cannabis
oversight
enforcement.
