Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Antibiotics, Год журнала: 2022, Номер 11(2), С. 200 - 200

Опубликована: Фев. 4, 2022

Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As result, infectious diseases have become more challenging or even impossible treat, leading an increase morbidity mortality. Despite the failure of conventional, traditional therapy, past two decades, no novel class antibiotics has been introduced. Consequently, several alternative strategies combat these (multi-) drug-resistant microorganisms identified. The purpose this review is gather consider that are being applied proposed as potential alternatives antibiotics. These include combination techniques target enzymes proteins responsible for resistant bacteria, drug delivery systems, physicochemical methods, unconventional techniques, including CRISPR-Cas system. may change treatment multi-drug-resistant pathogens human clinical settings.

Язык: Английский

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Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?

Antibiotics, Год журнала: 2020, Номер 9(4), С. 170 - 170

Опубликована: Апрель 10, 2020

Infectious diseases that are caused by bacteria an important cause of mortality and morbidity in all regions the world. Bacterial drug resistance has grown last decades, but rate discovery new antibiotics steadily decreased. Therefore, search for effective antibacterial agents become a top priority. The plant kingdom seems to be deep well searching novel antimicrobial agents. This is due many attractive features plants: they readily available cheap, extracts or compounds from sources often demonstrate high-level activity against pathogens, rarely have severe side effects. huge variety plant-derived provides very diverse chemical structures may supply both mechanisms action provide us with targets within bacterial cell. In addition, rapid development modern biotechnologies opens up way obtaining bioactive environmentally friendly low-toxic conditions. this short review, we ask question: do derived plants chance panacea infectious "post-antibiotics era".

Язык: Английский

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Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants

Antibiotics, Год журнала: 2022, Номер 11(10), С. 1380 - 1380

Опубликована: Окт. 9, 2022

The overuse of antibiotics in the past decades has led to emergence a large number drug-resistant microorganisms. In recent years, infection rate caused by multidrug-resistant microorganisms been increasing, which become one most challenging problems modern medicine. Plant-derived secondary metabolites and their derivatives have identified display significant antimicrobial abilities with good tolerance less adverse side effects, potentially having different action mechanisms microbial origin. Thus, these phyto-antimicrobials prospect treatment Terpenoids, alkaloids, flavonoids made up predominant part currently reported phytochemicals activities. Synthetic biology research around compounds is hotspot fields not only illuminated biosynthesis pathways but also offered new methods for production. this review, we discuss investigations terpenoid, alkaloid, flavonoid agents—using artemisinin oleanolic acid (terpenoids), berberine colchicine (alkaloids), baicalin (flavonoids) as examples—around mechanisms, pathway elucidation, key enzyme identification, heterologous production, order provide useful hints plant-derived agent discovery development.

Язык: Английский

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Clean-label alternatives for food preservation: An emerging trend

Heliyon, Год журнала: 2024, Номер 10(16), С. e35815 - e35815

Опубликована: Авг. 1, 2024

Язык: Английский

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Advantages and Challenges of Using Antimicrobial Peptides in Synergism with Antibiotics for Treating Multidrug-Resistant Bacteria

ACS Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Multidrug-resistant bacteria (MDR) have become a global threat, impairing positive outcomes in many cases of infectious diseases. Treating bacterial infections with antibiotic monotherapy has huge challenge modern medicine. Although conventional antibiotics can be efficient against bacteria, there is still need to develop antimicrobial agents that act MDR bacteria. Bioactive peptides, particularly effective specific types are recognized for their selective and action microorganisms and, at the same time, relatively safe well tolerated. Therefore, growing number works proposed use peptides (AMPs) synergism commercial as an alternative therapeutic strategy. This review provides overview critical parameters using AMPs addressing strengths weaknesses this combination therapy vitro vivo models infection. We also cover challenges perspectives approach clinical practice advantages applying artificial intelligence strategies predict most promising therapies between antibiotics.

Язык: Английский

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Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and anti-MRSA activities of extracts of some medicinal plants: A brief review

AIMS Microbiology, Год журнала: 2019, Номер 5(2), С. 117 - 137

Опубликована: Янв. 1, 2019

The increasing emergence of multidrug-resistant infection causing microorganisms has become a significant burden globally. Despite the efforts pharmaceuticals in producing relatively new antimicrobial drugs, they have resulted high rate mortality, disability and diseases across world especially developing countries. Supporting this claim was report Centre for Disease Control Prevention (CDC) who estimated that over 2 million illnesses 23,000 deaths per year are attributable to antibiotic resistant pathogens United States. They include Methicillin-resistant

Язык: Английский

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Isolation, Purification, and Antimicrobial Characterization of Cannabidiolic Acid and Cannabidiol from Cannabis sativa L.

Biomolecules, Год журнала: 2020, Номер 10(6), С. 900 - 900

Опубликована: Июнь 12, 2020

The emergence of multi-drug resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) causes a major threat to public health due its limited therapeutic options. There is an urgent need for the development new effective antimicrobial agents and alternative strategies that are against bacteria. parallel legalization cannabis products has fueled research into many avenues in countries around world. This study aimed at reliable method extraction, purification, characterization, quantification cannabidiolic acid (CBDA) decarboxylated form cannabidiol (CBD) present fiber type Cannabis sativa L. two compounds were extracted by ethanol, purified on C18 sep-pack column, extracts analyzed high performance liquid chromatography coupled with ultraviolet (UV)–vis ESI-MS (electrospray ionization mass spectrometry) detection. effect CBDA CBD was also evaluated. displayed substantial inhibitory Gram-positive minimal concentrations ranging from 1 2 µg/mL. Time kill analysis bactericidal concentration revealed potential activity CBD. While cannabinoids showed significant S. epidermidis, no noticed Gram-negative Escherichia coli Pseudomonas aeruginosa. presented two-fold lower than form, suggesting pharmacophore falls ability permeabilizing bacterial cell membrane acting detergent-like agent. A synergy test performed MRSA range antibiotics did not indicate synergetic effect, but noteworthy antagonist influence either. manifested low hemolytic human red blood cells. Likewise, safety toward keratinocyte cells presents toxicity up seven-fold higher antibacterial concentration. Similarly, both well tolerated mammals, including humans, conserve safe value limits blood-contacting drug development. Overall, exhibited strong strains could serve tackling MRSA.

Язык: Английский

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The multi-faceted potential of plant-derived metabolites as antimicrobial agents against multidrug-resistant pathogens

Microbial Pathogenesis, Год журнала: 2018, Номер 116, С. 209 - 214

Опубликована: Фев. 1, 2018

Язык: Английский

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Antibacterial activity of medicinal plants against ESKAPE: An update

Heliyon, Год журнала: 2021, Номер 7(2), С. e06310 - e06310

Опубликована: Фев. 1, 2021

Antibiotic resistance has emerged as a threat to global health, food security, and development today. can occur naturally but mainly due misuse or overuse of antibiotics, which results in recalcitrant infections Antimicrobial Resistance (AMR) among bacterial pathogens.These include the MDR strains (multi-drug resistant) ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species). These pathogens have potential "escape" antibiotics other traditional therapies. are responsible for major cases Hospital-Acquired Infections (HAI) globally. Pathogens been placed list 12 bacteria by World Health Organisation (WHO), against new is vital. It not only prolonged hospital stays also higher medical costs mortality. Therefore, antimicrobials need be developed battle rapidly evolving pathogens. Plants known synthesize an array secondary metabolites referred phytochemicals that disease prevention properties. Potential efficacy minimum no side effects key advantages plant-derived products, making them suitable choices treatments. Hence, this review attempts highlight discuss application compounds extracts Pathogens.

Язык: Английский

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Medicinal Plant Compounds for Combating the Multi-drug Resistant Pathogenic Bacteria: A Review

Current Pharmaceutical Biotechnology, Год журнала: 2019, Номер 20(3), С. 183 - 196

Опубликована: Март 11, 2019

Background: Globally, people utilize plants as the main source of remedy to heal various ailments. Medicinal have been utilized treat ailments since invention modern scientific systems medicine. The common infectious diseases mainly depends on inhibition capacity compounds or killing potential. issue may give a clue for development novel antimicrobial agent. Methods: Currently, microorganisms which are resistant towards antibiotics probably matter serious concern overall well-being health. At moment, new therapeutic targets aside from microorganism wall-based activities in progress. For instance, autoinducer molecules produced by quorum sensing system used control antibiotic resistance and biofilm formation. Results: This target is well-studied worldwide, however, data not updated only current studies started gain insight into its perspective struggle against diseases. Microbial topic recent time. Conclusion: Hence, this paper aims confer overview compounds, sensing, quenching, formation an update their importance potential natural substances.

Язык: Английский

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