Medicina,
Год журнала:
2024,
Номер
60(10), С. 1682 - 1682
Опубликована: Окт. 14, 2024
Parkinson's
disease
(PD)
is
a
pathological
state
characterized
by
combined
set
of
abnormal
movements
including
slow
motion,
resting
tremors,
profound
stiffness
skeletal
muscles,
or
obvious
abnormalities
in
posture
and
gait,
together
with
significant
behavioral
changes.
Until
now,
no
single
therapeutic
modality
was
able
to
provide
complete
cure
for
PD.
This
work
trial
assess
the
immunomodulatory
effects
canagliflozin
without
levodopa/carbidopa
on
rotenone-induced
parkinsonism
Balb/c
mice.
Results in Chemistry,
Год журнала:
2024,
Номер
9, С. 101614 - 101614
Опубликована: Июнь 27, 2024
We
introduce
silver-copper
nanoparticles
incorporated
into
polyaniline
(PANI)
nanotubes
using
a
straightforward
and
efficient
reduction
process.
In
this
regard,
PANI
with
amine
groups
were
fabricated
through
oxidation
polymerization,
followed
by
the
attachment
of
Ag
Cu
precursors
to
enable
synthesis
Ag-Cu
bimetallic
(NPs)
on
pre-formed
use
hydrazine
as
reducing
agent.
The
structural
characterization
synthesized
NPs
was
investigated
UV–Vis
spectrophotometer
(UV–Vis),
Dark-field
emission,
(EDX),
X-ray
diffraction
(XRD)
field
emission
(FESEM),
while
electrochemical
properties
estimated
(CV)
differential
pulse
voltammetry
(DPV).
findings
indicated
that
present
in
nanoscale
range,
well-dispersed,
attached
surface
nanotubes.
Electrochemical
investigations
revealed
Ag-Cu@PANI
nanotube
electrode
demonstrated
electrooxidation
dopamine
hydroquinone
without
any
interfering
reactions,
suggesting
its
potential
an
biosensor
for
simultaneous
detection
hydroquinone.
proposed
NPs-based
connected
concurrently
identify
hydroquinone,
illustrating
moo
distinguish
Confinements
0.46
µM
0.23
mM
separately.
Additionally,
manufactured
sensor
identified
wide
direct
run
(5–25
µM),
(0.5–2.5
mM).
Alongside
these
promising
comes
about,
actualized
great
solidness
reproducibility,
making
it
favorable
stage
biosensing
Mathematics,
Год журнала:
2024,
Номер
12(10), С. 1575 - 1575
Опубликована: Май 18, 2024
The
detection
of
Parkinson’s
disease
(PD)
is
vital
as
it
affects
the
population
worldwide
and
decreases
quality
life.
disability
death
rate
due
to
PD
increasing
at
an
unprecedented
rate,
more
than
any
other
neurological
disorder.
To
this
date,
no
diagnostic
procedures
exist
for
disease.
However,
several
computational
approaches
have
proven
successful
in
detecting
early
stages,
overcoming
disadvantages
traditional
methods
diagnosis.
In
study,
a
machine
learning
(ML)
system
based
on
voice
signals
patients
proposed.
AdaBoost
classifier
has
been
utilized
construct
model
trained
dataset
obtained
from
repository
University
California,
Irvine
(UCI).
This
includes
attributes
such
time-frequency
features,
Mel
frequency
cepstral
coefficients,
wavelet
transform
vocal
fold
tremor
waveform
time.
demonstrated
promising
performance,
achieving
high
accuracy,
precision,
recall,
F1
score,
AUC
score
0.96,
0.98,
0.93,
0.95,
0.99,
respectively.
Furthermore,
robustness
proposed
rigorously
assessed
through
cross-validation,
revealing
consistent
performance
across
all
iterations.
overarching
objective
study
contribute
scientific
community
by
furnishing
robust
PD.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(6), С. 5929 - 5949
Опубликована: Июнь 13, 2024
Semaglutide
(SEM),
a
glucagon-like
peptide-1
receptor
agonist,
has
garnered
increasing
interest
for
its
potential
therapeutic
effects
in
neurodegenerative
disorders
such
as
Alzheimer’s
disease
(AD)
and
Parkinson’s
(PD).
This
review
provides
comprehensive
description
of
SEM’s
mechanism
action
preclinical
studies
these
debilitating
conditions.
In
animal
models
AD,
SEM
proved
beneficial
on
multiple
pathological
hallmarks
the
disease.
administration
been
associated
with
reductions
amyloid-beta
plaque
deposition
mitigation
neuroinflammation.
Moreover,
treatment
shown
to
ameliorate
behavioral
deficits
related
anxiety
social
interaction.
SEM-treated
animals
exhibit
improvements
spatial
learning
memory
retention
tasks,
evidenced
by
enhanced
performance
maze
navigation
tests
novel
object
recognition
assays.
Similarly,
PD,
demonstrated
promising
neuroprotective
through
various
mechanisms.
These
include
modulation
neuroinflammation,
enhancement
mitochondrial
function,
promotion
neurogenesis.
Additionally,
improve
motor
function
dopaminergic
neuronal
loss,
offering
disease-modifying
strategies.
Overall,
accumulating
evidence
from
suggests
that
holds
promise
approach
AD
PD.
Further
research
is
warranted
elucidate
underlying
mechanisms
translate
findings
into
clinical
applications
devastating
disorders.
CNS & Neurological Disorders - Drug Targets,
Год журнала:
2024,
Номер
23(10), С. 1251 - 1262
Опубликована: Фев. 14, 2024
Abstract:
The
potential
of
nanotechnology
in
advancing
the
diagnosis
and
treatment
neurodegenerative
diseases
is
explored
this
comprehensive
literature
review.
findings
these
studies
suggest
that
has
capacity
to
improve
existing
therapeutic
approaches,
create
novel
safe
compounds,
develop
more
precise
imaging
techniques
diagnostic
methods
for
diseases.
With
emergence
nanomedicine
era,
a
new
innovative
approach
diagnosing
treating
conditions
been
introduced.
Notably,
researchers'
development
nanocarrier
drug
delivery
tool
demonstrates
immense
compared
conventional
therapy,
as
it
maximizes
efficacy
minimizes
undesirable
side
effects.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12379 - 12379
Опубликована: Ноя. 18, 2024
Parkinson's
disease
(PD)
is
a
progressive
neurological
that
causes
both
motor
and
nonmotor
symptoms.
While
our
understanding
of
putative
mechanisms
has
advanced
significantly,
it
remains
challenging
to
verify
biomarkers
with
sufficient
evidence
for
regular
clinical
use.
Clinical
symptoms
are
the
primary
basis
diagnosing
disease,
which
can
be
mild
in
early
stages
overlap
other
disorders.
As
result,
testing
medical
records
mostly
relied
upon
diagnosis,
posing
substantial
challenges
during
initial
diagnosis
continuous
monitoring.
Recent
biochemical,
neuroimaging,
genetic
have
helped
us
understand
pathophysiology
disease.
This
comprehensive
study
focuses
on
these
biomarkers,
were
chosen
based
their
relevance,
methodological
excellence,
contribution
field.
Biochemical
including
α-synuclein
glial
fibrillary
acidic
protein
(GFAP),
predict
severity
progression.
The
dopaminergic
system
widely
used
as
neuroimaging
biomarker
diagnose
PD.
Numerous
genes
genome
wide
association
(GWAS)
sites
been
related
development
research
SNCA
gene
leucine-rich
repeat
kinase
2
(LRRK2)
shown
promising
results.
By
evaluating
current
studies,
this
review
intends
uncover
gaps
validation
use,
while
also
highlighting
improvements.
It
emphasizes
need
dependable
reproducible
indicators
improving
PD
prognosis.
These
may
open
up
new
avenues
progression
tracking,
personalized
treatment
programs.
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 917 - 917
Опубликована: Июль 29, 2024
Parkinson's
disease
is
one
of
the
most
prevalent
neurological
disorders
affecting
millions
people
worldwide.
There
a
growing
demand
for
novel
and
natural
substances
as
complementary
therapies.
Essential
oils
their
various
compounds
are
highly
investigated
plant-based
products
potential
treatment
options
common
human
diseases,
such
microbial
infections,
chronic
neurodegenerative
disorders.
The
present
study
focuses
on
beneficial
effects
linalool
geraniol,
major
lavender
(
