The Neurobehavioral Impact of Zinc Chloride Exposure in Zebrafish: Evaluating Cognitive Deficits and Probiotic Modulation

Toxics, Год журнала: 2025, Номер 13(3), С. 193 - 193

Опубликована: Март 8, 2025

Zinc contamination in aquatic environments has become a growing concern due to its potential bioaccumulate and induce neurotoxic effects organisms. As an essential trace element, zinc plays crucial role various physiological processes, but excessive exposure can disrupt the gut–brain axis, leading cognitive behavioral impairments. Recent studies have suggested that probiotics may offer protective against environmental neurotoxins by modulating gut microbiota associated neurological functions. The zebrafish (Danio rerio) emerged as valuable model organism for studying biological mechanisms underlying neurotoxicity therapeutic interventions. This study aimed assess of on impairments induced chloride (ZnCl2) zebrafish. Specifically, were exposed ZnCl2 at concentrations 0.5 mg/L 1.0 96 h, followed 7-day post-exposure period (Bifidobacterium longum, Bifidobacterium animalis lactis, Lactobacillus rhamnosus). these is already known neuromotor deficits resembling Alzheimer’s disease-like symptoms models, making it suitable evaluating neuroprotective probiotics. Behavioral assessments including sociability tests along with short- long-term memory evaluations conducted using EthoVision XT 16 software. Memory demonstrated impaired functions, while probiotic treatment did not significantly ameliorate deficits. In social behavior test, resulted marked decrease sociability, whereas significant changes. However, administration following intoxication exhibited anxiolytic effect These findings suggest exhibit partial neurobehavioral benefits chloride-induced toxicity, particularly mitigating anxiety-like behaviors rather than Further investigations are needed elucidate precise which interact axis context heavy metal neurotoxicity.

Язык: Английский

Ergosterol originated from Auricularia auricula attenuates high fat diet-induced obesity and cognitive impairment in mice

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Ergosterol and Auricularia auricula attenuates high fat diet-induced obesity cognitive impairment in mice by regulating gut microbiota inhibiting the activation of microglia.

Язык: Английский

Galbanic acid delays the development of seizures by modulating the expression of TNFα, IL1β, and TLR4 genes and reducing hippocampal nitrite levels and may be useful in the treatment of epilepsy

Neuroscience Letters, Год журнала: 2025, Номер unknown, С. 138200 - 138200

Опубликована: Март 1, 2025

Язык: Английский