Robotics-assisted modular assembly of bioactive soft materials for enhanced organ fabrication
Virtual and Physical Prototyping,
Год журнала:
2024,
Номер
19(1)
Опубликована: Авг. 19, 2024
Tissue
engineering,
an
interdisciplinary
field,
aims
to
restore,
maintain,
or
enhance
tissue
function
by
developing
biological
substitutes.
To
establish
optimal
microenvironment,
biofabrication
is
acknowledged
as
a
revolutionary
technology
facilitating
the
construction
of
multiscale
three-dimensional
architectures
utilising
various
living
cells
and
biomaterials.
A
critical
challenge
in
this
domain
precise
assembly
soft
matter-delicate
pliable
structures
-
essential
for
creating
functional
tissues
organs.
This
review
focuses
on
increasing
use
robotic
systems
address
challenge,
exploring
their
application
manipulating
matter
assembly.
Robotic
technologies
offer
innovative
solutions
handling
with
precision
control.
discusses
how
can
be
leveraged
fabricate
complex
organs,
detailing
role
replicating
structural
complexities
natural
tissues.
Further,
examining
latest
advancements
robotics-assisted
highlights
potential
robotics
revolutionise
organ
fabrication,
offering
promising
longstanding
challenges
field.
These
technological
hold
capacity
engineer
presenting
considerable
translational
clinical
applications.
Язык: Английский
Advances and Challenges in 3D Modelling of Organ-on-a-Chip Devices with a Focus on the Glomerular Basement Membrane (GBM) and Tubular Systems: A Critical Review
BioChip Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Detrimental Effects of Advanced Glycation End-products (AGEs) on a 3D Skeletal Muscle Model in Microphysiological System
Biosensors and Bioelectronics,
Год журнала:
2025,
Номер
278, С. 117316 - 117316
Опубликована: Фев. 27, 2025
Язык: Английский
Investigation of Collagen Network Microstructure and Vascular Sprouting On-Chip Using Non-enzymatic Glycation
BioChip Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Язык: Английский
Evaluation of mitochondrial activity via cellular interactions between adrenal and neuronal cells in a microfluidic coculture device
Jae Seong Kim,
Huiseong Son,
Jihun Han
и другие.
Biotechnology and Bioprocess Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Язык: Английский
Engineered Blood Clots for Embolization in a 3D Microfluidic Chip Model Mimicking Vascular Structures
BioChip Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 20, 2025
Язык: Английский
FOLR1-Targeted Oxygen-Delivering Nanosomes Enhance Chemo-Induced Apoptosis in Hypoxic Cancer
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 6875 - 6889
Опубликована: Май 1, 2025
The
rapid
proliferation
of
tumor
cells
increases
oxygen
demand,
while
the
underdeveloped
vasculature
limits
supply,
leading
to
hypoxia
in
microenvironment.
This
hypoxic
condition
is
a
hallmark
solid
tumors
and
contributes
progression,
immune
suppression,
metastasis,
resistance
therapy.
study
aimed
counteract
improve
therapeutic
outcomes
by
delivering
both
chemotherapeutic
agent
doxorubicin
directly
tumors.
HON_FA@DOX,
folate-functionalized
perfluorohexane-enhanced
liposomal
nanosome
co-loaded
with
doxorubicin,
was
developed
characterized
based
on
its
physical
properties.
Its
tumor-targeting
capability,
delivery
efficiency,
potential
were
evaluated
under
vitro
conditions.
Cellular
experiments
conducted
assess
selective
binding,
modulation,
cytotoxicity,
expression
genes
related
apoptosis.
HON_FA@DOX
exhibited
encapsulation
efficiency
36.6%
an
enhanced
loading
capacity
23.2
mg/L.
nanosomes
demonstrated
binding
FOLR1-expressing
sustained
release
doxorubicin.
dual-delivery
system
effectively
alleviated
within
microenvironment
reduced
hypoxia-related
gene
HIF-1α
50%.
Furthermore,
treatment
significantly
increased
apoptosis-related
mitigated
chemotherapy
resistance,
thereby
enhancing
overall
anticancer
efficacy.
We
that
multifunctional
approach
presents
promising
strategy
for
addressing
may
be
broadly
applicable
as
adjunct
conventional
cancer
therapies.
Язык: Английский
Surface Tension-Based Open Microfluidic Platform Using Micropillars to Recreate the 3D Lung Cellular Microenvironment
BioChip Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Язык: Английский
Experimental Study on the Process and Performance of Pre‐Dressing‐Assisted Laser Joining of Vascular Tissues
Journal of Biophotonics,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
ABSTRACT
Blood
vessels
are
an
important
part
of
the
human
circulatory
system.
In
clinical
surgery,
common
method
for
treating
ruptured
blood
is
suturing,
but
this
can
cause
inflammatory
reactions.
With
popularization
lasers,
they
have
been
widely
used
in
medical
field.
However,
due
to
poor
absorption
laser
energy
by
tissues,
tensile
strength
tissues
after
joining
low.
To
further
improve
joining,
study
analyzed
law
effect
pre‐dressing‐assisted
on
and
thermal
denaturation
vascular
with
different
components
concentrations
designing
experiments.
The
experimental
results
showed
that
joined
could
reach
50.978
KPa,
degree
was
only
0.025,
which
great
significance
laser‐joined
tissues.
Язык: Английский