Molecular Neurobiology, Год журнала: 2023, Номер 60(4), С. 2005 - 2023
Опубликована: Янв. 4, 2023
Язык: Английский
Aging and Disease, Год журнала: 2023, Номер 14(3), С. 605 - 605
Опубликована: Янв. 1, 2023
The increase in life expectancy is accompanied with an increased consultation of age-related pathologies including endocrine disorders. Two main areas are focusing the attention medical and social research older population: diagnosis care this heterogeneous population, interventional measures potentially useful to mitigate functional declines health quality lifespan. Thus, better understanding physiopathology aging establishing accurate diagnostic personalized approaches a priority currently unmet need community. system plays major role survival lifespan through regulating vital processes such as energy consumption optimizing stress response among others. aim paper review physiological evolution hormonal functions its clinical translation improve our approach patient.
Язык: Английский
Процитировано
11
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 22, 2024
Glycolysis-derived lactate was identified as substrate for histone lactylation, which has been regarded a significant role in transcriptional regulation many tissues. However, the of lactylation metabolic center, hypothalamus, is still unknown. Here, we show that hypothalamic pro-opiomelanocortin (POMC) neuron-specific deletion family with sequence similarity 172, member A (Fam172a) can increase and protect mice against diet-induced obesity (DIO) related disorders. Conversely, overexpression Fam172a POMC neurons led to an obesity-like phenotype. Using RNA-seq CUT&Tag chromatin profiling analyzes, find knockdown activates glycolytic process increases peptidylglycine α-amidating monooxygenase (PAM), affects synthesis α-MSH, via H4K12la (histone lactylation). In addition, pharmacological inhibition production clearly abrogates anti-obesity effect PFKO (POMC-Cre, Fam172aloxP/loxP, knockout). These findings highlight importance development our results mainly concern male mice. reported play regulation. it's hypothalamus authors disorders
Язык: Английский
Процитировано
4
Frontiers in Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Фев. 27, 2025
The prevalence of female-to-male (FtM) transgender individuals has risen recently, yet the effects cross-sex hormone therapy on volumetric differences in hippocampal subfields remain poorly understood. This study aimed to evaluate gray matter (GM) volume, especially focusing subfields, FtM and premenopausal cisgender women. Seventeen who had undergone hysterectomies were receiving testosterone before participating this study, along with 20 women, underwent a single session T1-weighted magnetic resonance imaging (MRI). group significantly higher free-testosterone (free-T) levels lower estradiol compared women (p < 0.001). In voxel-wise analysis, showed larger GM volumes caudate nucleus, hypothalamus, thalamus 0.01, FWE-corrected). More specifically, right subiculum volume was 0.05, Bonferroni-corrected), these positively correlated free-T (r = 0.34, p 0.04). revealed specific subfield testosterone-treated when group. These findings might help elucidate morphological variation cerebral regions associated contribute our understanding gender-affirming treatments as well.
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Март 10, 2025
Hypothalamic GABAergic neurons are important in regulating metabolic homeostasis and energy balance. Serving as critical integrators of catabolic anabolic processes, these orchestrate a broad spectrum functions, including feeding, nutrient metabolism, fluid homeostasis, basal thermoregulation, circadian rhythms. Recent advances neuroscience have facilitated deeper exploration the role hypothalamic regulation. Emerging research has uncovered key mechanisms through which modulate balance maintain These findings not only enhance our understanding obesity related disorders but also underscore link between dysfunction prevalent diseases such type 2 diabetes. This review summarizes latest advancements It aims to elucidate neural molecular underlying control offering new perspectives for diagnosis treatment disorders.
Язык: Английский
Процитировано
0
Theory and practice of meat processing, Год журнала: 2025, Номер 10(1), С. 11 - 31
Опубликована: Апрель 6, 2025
This review examines the impact of fast food consumption on health and its role in development chronic diseases that accelerate aging process. A comprehensive literature was conducted to explore relationship between intake onset cardiovascular diseases, diabetes, cancer, obesity, all which are associated with premature aging. The findings indicate foods high fat sugar contribute inflammation — a phenomenon referred as “inflammageing”, damages vascular system heightens risk including atherosclerosis heart failure. Additionally, metabolic disorders such insulin resistance dyslipidemia disrupt glucose homeostasis, further exacerbating promoting accelerated Moreover, is linked an increased largely due presence carcinogenic compounds processed meats obesity epidemic, amplifies through mechanisms involving inflammation, oxidative stress, hormonal imbalances. Collectively, these factors impair immune function elevate neurodegenerative diseases. Consequently, significantly contributes by fostering disorders, stress. Urgent public interventions necessary mitigate adverse effects promote healthier dietary patterns, enhance quality life longevity.
Язык: Английский
Процитировано
0
The Journal of Nutritional Biochemistry, Год журнала: 2024, Номер 129, С. 109637 - 109637
Опубликована: Апрель 3, 2024
Язык: Английский
Процитировано
3
Acta Neurochirurgica, Год журнала: 2025, Номер 167(1)
Опубликована: Фев. 4, 2025
Abstract Background Deep brain stimulation (DBS) has been successfully used for the treatment of circuitopathies including movement, anxiety, and behavioral disorders. The hypothalamus is a crucial integration center many peripheral central pathways relating to cardiovascular, metabolic, functions constitutes potential target neuromodulation in treatment-refractory conditions. To conduct systematic review, investigating hypothalamic targets DBS, their indications, primary clinical findings. Methods PubMed, Scopus, Web Science databases were searched accordance with PRISMA guideline identify papers published English studying DBS humans. Results After screening 3,148 papers, 34 studies consisting 412 patients over two decades included final review. Hypothalamic was indicated refractory headaches ( n = 238, 57.8%), aggressive behavior 100, 24.3%), mild Alzheimer’s disease 58, 14.1%), trigeminal neuralgia multiple sclerosis 5, 1.2%), Prader-Willi syndrome 4, 0.97%), atypical facial pain 3, 0.73%). posterior most common site across 30 (88.2%). 262 (63.6%) participants males, 110 (26.7%) females. 303 (73.5%) adults whereas 33 (8.0%) pediatrics. lowest mean age 15.25 ± 4.6 years chronic aggressiveness, highest 68.5 7.9 patients. duration ranged from 2.2 1.7 (mild disease) 19.8 10.1 (refractory headaches). 213 (51.7%) 29 (85.3%) reported symptom improvements which 23.1% 100%. 25 complications, associated higher voltage stimulations. Conclusions feasible selected various conditions ranging aggression both pediatric adult populations. Future large-scale long-term follow-up are required validate safety efficacy data extend these
Язык: Английский
Процитировано
0
Molecular Psychiatry, Год журнала: 2025, Номер unknown
Опубликована: Март 3, 2025
O-GlcNAcylation, a dynamic post-translational modification occurring on serine or threonine residues of numerous proteins, plays pivotal role in various cellular processes, including gene regulation, metabolism, and stress response. Abundant the brain, O-GlcNAcylation intricately governs neurodevelopment, synaptic assembly, neuronal functions. Recent investigations have established correlation between dysregulation brain broad spectrum neurological disorders injuries, spanning neurodevelopmental, neurodegenerative, psychiatric conditions, as well injuries to central nervous system (CNS). Manipulating has demonstrated neuroprotective properties against these afflictions. This review delineates roles mechanisms CNS under both physiological pathological circumstances, with focus its effects injuries. We discuss involvement key processes such neurogenesis, plasticity, energy implications conditions like Alzheimer's disease, Parkinson's ischemic stroke. Additionally, we explore prospective therapeutic approaches for by targeting highlighting recent clinical developments future research directions. comprehensive overview aims provide insights into potential target guide this promising field.
Язык: Английский
Процитировано
0
BMC Microbiology, Год журнала: 2025, Номер 25(1)
Опубликована: Март 14, 2025
The drop of dry matter intake (DMI) and rise milk production in transitional dairy cows would mobilize reserved fat disrupt lipid metabolism, eventually attributed to negative energy balance (NEB) immune injury. positive effect n-3 polyunsaturated fatty acids (PUFA) on regulating metabolism inflammation has been elucidated, however, the lack regulatory mechanism deserves further investigation. In this study, 30 Holstein transition were divided into control (CON) HN3 groups based n-3: n-6 PUFA ratio diet. results showed that compared CON group, high ratio-supplemented prepartum phase reduced relative abundance gram-negative bacteria rumen, concentration lipopolysaccharide plasma liver also significantly decreased (P < 0.05). Transcriptomic analysis NF-κB signaling pathway down-regulated taste transduction up-regulated 0.05) group. postpartum phase, a n-3/n-6 diet increased Prevotella, Succinimonas Treponema at same time, orexins changed Further, insulin resistance liver. Overall, these attenuates inflammatory responses increases protein cows. Appropriate increase proportion may be an effective measure alleviate metabolic disease
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Март 21, 2025
Background Obesity has become a significant public health issue, yet its underlying mechanisms remain complex. The hypothalamus, crucial part of the central nervous system, plays vital role in maintaining energy balance. Disruptions hypothalamic homeostasis can lead to obesity and related metabolic disorders. Recent studies have increasingly focused on intercellular interactions within hypothalamus development, though exact are still under investigation. Mast cells, as innate immune been linked obesity, but their specific roles require further exploration. This study aims investigate whether mast cells influence microglia subsequently affect homeostasis. Methods We conducted experiments examine effects high-fat diets arcuate nucleus hypothalamus. analyzed activation activity POMC neurons response cell activation. involved feeding mice diet then assessing changes populations, microglial activation, neuronal Results Our findings indicate that increases number These activate microglia, which turn suppress neurons. suppression promotes appetite reduces expenditure, leading obesity. results suggest direct regulation balance development. Discussion highlights regulatory formation By activating influencing neuron activity, contribute dysregulation. provide new target for treatment diseases, emphasizing importance health. Further research is needed explore potential therapeutic applications targeting management.
Язык: Английский
Процитировано
0