Neuropharmacology, Год журнала: 2022, Номер 207, С. 108966 - 108966
Опубликована: Янв. 22, 2022
Язык: Английский
Biomedicines, Год журнала: 2024, Номер 12(2), С. 257 - 257
Опубликована: Янв. 23, 2024
Chaperone-mediated autophagy (CMA) is a selective proteolytic pathway in the lysosomes. Proteins are recognized one by through detection of KFERQ motif or, at least, KFERQ-like motif, heat shock cognate protein 70 (Hsc70), molecular chaperone. CMA substrates and delivered to lysosomal receptor, lysosome-associated membrane 2A (LAMP-2A), only limiting component this pathway, transported lumen with help another resident chaperone HSp90. Since approximately 75% proteins reported have canonical, phosphorylation-generated, or acetylation-generated motifs, maintains intracellular homeostasis regulates specific functions cells different tissues. also physiologic organs, then implicated disease pathogenesis related aging, cancer, central nervous immune systems. In minireview, we summarized most important findings on role tissue pathogenesis, updating recent advances for Special Issue.
Язык: Английский
Процитировано
14
Industrial & Engineering Chemistry Research, Год журнала: 2025, Номер 64(4), С. 1907 - 1932
Опубликована: Янв. 14, 2025
Metal–organic frameworks (MOFs) have been shown to be great alternatives traditional porous materials in various chemical applications, and they very widely studied for biomedical applications the past decade specifically drug storage. After our review published 2011 [Keskin Kızılel, Ind. Eng. Chem. Res. 2011, 50 (4), 1799–1812, 10.1021/ie101312k], we witnessed a fast growth not only number variety of MOFs but also their usage across broad spectrum fields. With recent integration molecular modeling data science approaches experimental studies, significantly accelerated positioning them as pivotal components regenerative medicine, medical imaging, diagnostics. In this review, visited diverse considering computational efforts on storage delivery, bioimaging, biosensing. We focused underlying mechanisms governing interactions between biological systems discussed both opportunities challenges field highlight potential advanced therapeutics cancer neurological diseases.
Язык: Английский
Процитировано
2
Cells, Год журнала: 2022, Номер 11(14), С. 2250 - 2250
Опубликована: Июль 20, 2022
Chaperone-mediated autophagy (CMA) is a protein degradation mechanism through lysosomes. By targeting the KFERQ motif of substrate, CMA responsible for about 30% cytosolic proteins, including series proteins associated with neurodegenerative diseases (NDs). The fact that decreased activity observed in NDs, and ND-associated mutant alpha-synuclein Tau, directly impair reveals possible vicious cycle impairment pathogenic accumulation ND development. Given intrinsic connection between dysfunction ND, enhancement has been regarded as strategy to counteract ND. Indeed, genetic pharmacological approaches modulate have shown promote alleviate phenotypes multiple models. This review summarizes current knowledge on focus its relationship NDs discusses therapeutic potential modulation
Язык: Английский
Процитировано
35
Cells, Год журнала: 2022, Номер 11(7), С. 1205 - 1205
Опубликована: Апрель 2, 2022
Autophagy is an important function that mediates the degradation of intracellular proteins and organelles. Chaperone-mediated autophagy (CMA) degrades selected has a crucial role in cellular proteostasis under various physiological pathological conditions. CMA dysfunction leads to accumulation toxic protein aggregates central nervous system (CNS) involved pathogenic process neurodegenerative diseases, including Parkinson’s disease Alzheimer’s disease. Previous studies have suggested activation degrade aberrant can provide neuroprotective effect CNS. Recent shown activity upregulated damaged neural tissue following acute neurological insults, such as cerebral infarction, traumatic brain injury, spinal cord injury. It been also mechanisms are for removing associated with secondary damage after insults Therefore, enhancing pathway may induce effects not only neurogenerative diseases but insults. We herein review current knowledge concerning biological highlight discuss possibility developing CMA-targeted therapeutic strategies effective treatments.
Язык: Английский
Процитировано
34
Neuropharmacology, Год журнала: 2022, Номер 207, С. 108966 - 108966
Опубликована: Янв. 22, 2022
Язык: Английский
Процитировано
32