Advances in clinical chemistry, Год журнала: 2024, Номер unknown, С. 1 - 88
Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2021, Номер 23(1), С. 90 - 90
Опубликована: Дек. 22, 2021
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level and play an important role in many cellular processes, including modulation of inflammation. MiRNAs present high concentrations central nervous system (CNS) spatially temporally expressed a specific way. Therefore, imbalance pattern these can be involved development neurological diseases. Generally, CNS responds to damage or disease through activation inflammatory response, but disorders characterized by uncontrolled neuroinflammation. Many studies support involvement miRNAs inhibition signaling promotion neuroinflammation with pathological consequences. MiR-155 is pro-inflammatory mediator plays regulatory role. The purpose this review summarize how miR-155 regulated consequences its deregulation during neuroinflammatory disorders, multiple sclerosis, Alzheimer’s other disorders. Modulation miRNAs’ could used as therapeutic strategy treatment
Язык: Английский
Процитировано
104
Gut Microbes, Год журнала: 2023, Номер 15(1)
Опубликована: Янв. 22, 2023
Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to formation of Aβ plaques brain, and gut microbiota appears exert an impact on Alzheimer's disease (AD) via gut-brain axis, although detailed mechanisms are not clearly defined. The current study focused uncovering potential interactions among gut-derived aging, microbiota, AD pathogenesis. To achieve this goal, expression levels several key proteins involved metabolism were initially assessed mouse with results confirmed human tissue. demonstrated that a high level was detected throughout both mice human, Aβ42 increased age wild type mutant amyloid precursor protein/presenilin 1 (APP/PS1) mice. Next, microbiome characterized by 16S rRNA sequencing, we found altered significantly aged APP/PS1 fecal transplantation (FMT) BACE1 levels. Intra-intestinal injection isotope or fluorescence labeled combined vagotomy also performed investigate transmission from brain. data showed that, mice, transported brain mainly blood rather than vagal nerve. Furthermore, FMT induced neuroinflammation, phenotype mimics early pathology. Taken together, suggests is likely critical source can further upregulate production, thereby potentially contributing
Язык: Английский
Процитировано
67
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114581 - 114581
Опубликована: Март 24, 2023
Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese medicine. Accumulating evidence has indicated that puerarin demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders. Based on the latest research progress as a neuroprotective agent, its activity, molecular mechanism, therapeutic application were systematically reviewed with emphasis pre-clinical studies. The related information was extracted compiled major scientific databases, including PubMed, ScienceDirect, SpringerLink, National Knowledge Infrastructure, using 'Puerarin', 'Neuroprotection', 'Apoptosis', 'Autophagy', 'Antioxidant', 'Mitochondria', 'Anti-inflammation' keywords. This review complied Preferred Reporting Items Systematic Reviews criteria. Forty-three articles met established inclusion exclusion shown against variety of disorders, ischemic cerebrovascular disease, subarachnoid hemorrhage, epilepsy, cognitive traumatic brain injury, Parkinson's Alzheimer's anxiety, depression, diabetic neuropathy, neuroblastoma/glioblastoma. anti-apoptosis, proinflammatory mediator inhibitory, autophagy regulatory, anti-oxidative stress, mitochondria protection, Ca2+ influx anti-neurodegenerative activities. exerts noticeable models disorders vivo (animal). will contribute to development novel clinical drug candidate However, well-designed, high-quality, large-scale, multicenter randomized studies are needed determine safety utility patients
Язык: Английский
Процитировано
48
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Сен. 20, 2024
Язык: Английский
Процитировано
37
Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(2), С. 457 - 477
Опубликована: Март 12, 2024
Язык: Английский
Процитировано
35
Brain Behavior and Immunity, Год журнала: 2024, Номер 117, С. 428 - 446
Опубликована: Фев. 7, 2024
Язык: Английский
Процитировано
29
Immunity, Год журнала: 2024, Номер 57(4), С. 790 - 814
Опубликована: Апрель 1, 2024
Язык: Английский
Процитировано
21
Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102233 - 102233
Опубликована: Фев. 14, 2024
Язык: Английский
Процитировано
18
eLife, Год журнала: 2025, Номер 14
Опубликована: Янв. 14, 2025
As the world population ages, new molecular targets in aging and Alzheimer's disease (AD) are needed to combat expected influx of AD cases. Until now, role RNA structure neurodegeneration has largely remained unexplored. In this study, we examined human hippocampal postmortem tissue for formation G-quadruplexes (rG4s) AD. We found that rG4 immunostaining strongly increased hippocampus with both age severity. further neurons accumulation phospho-tau contained rG4s, can drive tau aggregation, staining density depended on APOE genotype examined. Combined previous studies showing dependence stress extreme power rG4s at oligomerizing proteins, propose a model which chronic is linked proteostasis collapse. These morphological findings suggest investigation critical avenue future treatments diagnoses.
Язык: Английский
Процитировано
2
Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 754, С. 151526 - 151526
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
2