Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 28
Опубликована: Июнь 23, 2024
Alzheimer's
disease
(AD)
is
the
most
common
neurodegenerative
disease,
which
mainly
caused
by
damage
of
structure
and
function
central
nervous
system.
At
present,
there
are
many
adverse
reactions
in
market-available
drugs,
can't
significantly
inhibit
occurrence
AD.
Therefore,
current
focus
research
to
find
safe
effective
therapeutic
drugs
improve
clinical
treatment
Oxidative
stress
bridges
different
mechanism
hypotheses
AD
plays
a
key
role
Numerous
studies
have
shown
that
natural
flavonoids
good
antioxidant
effects.
They
can
directly
or
indirectly
resist
oxidative
stress,
Aβ
aggregation
Tau
protein
hyperphosphorylation
activating
Nrf2
other
oxidation-antioxidation-related
signals,
regulating
synaptic
function-related
pathways,
promoting
mitochondrial
autophagy,
etc.,
play
neuroprotective
In
this
review,
we
summarised
inhibiting
oxidative
injury
recent
years.
Moreover,
because
shortcomings
poor
biofilm
permeability
low
bioavailability
flavonoids,
advantages
progress
nano-drug
delivery
systems
such
as
liposomes
solid
lipid
nanoparticles
were
highlighted.
We
hope
review
provides
useful
way
explore
treatments.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
23(1), С. 90 - 90
Опубликована: Дек. 22, 2021
MicroRNAs
(miRNAs)
are
small
non-coding
RNA
molecules
that
regulate
gene
expression
at
the
post-transcriptional
level
and
play
an
important
role
in
many
cellular
processes,
including
modulation
of
inflammation.
MiRNAs
present
high
concentrations
central
nervous
system
(CNS)
spatially
temporally
expressed
a
specific
way.
Therefore,
imbalance
pattern
these
can
be
involved
development
neurological
diseases.
Generally,
CNS
responds
to
damage
or
disease
through
activation
inflammatory
response,
but
disorders
characterized
by
uncontrolled
neuroinflammation.
Many
studies
support
involvement
miRNAs
inhibition
signaling
promotion
neuroinflammation
with
pathological
consequences.
MiR-155
is
pro-inflammatory
mediator
plays
regulatory
role.
The
purpose
this
review
summarize
how
miR-155
regulated
consequences
its
deregulation
during
neuroinflammatory
disorders,
multiple
sclerosis,
Alzheimer’s
other
disorders.
Modulation
miRNAs’
could
used
as
therapeutic
strategy
treatment
Peripheral
β-amyloid
(Aβ),
including
those
contained
in
the
gut,
may
contribute
to
formation
of
Aβ
plaques
brain,
and
gut
microbiota
appears
exert
an
impact
on
Alzheimer's
disease
(AD)
via
gut-brain
axis,
although
detailed
mechanisms
are
not
clearly
defined.
The
current
study
focused
uncovering
potential
interactions
among
gut-derived
aging,
microbiota,
AD
pathogenesis.
To
achieve
this
goal,
expression
levels
several
key
proteins
involved
metabolism
were
initially
assessed
mouse
with
results
confirmed
human
tissue.
demonstrated
that
a
high
level
was
detected
throughout
both
mice
human,
Aβ42
increased
age
wild
type
mutant
amyloid
precursor
protein/presenilin
1
(APP/PS1)
mice.
Next,
microbiome
characterized
by
16S
rRNA
sequencing,
we
found
altered
significantly
aged
APP/PS1
fecal
transplantation
(FMT)
BACE1
levels.
Intra-intestinal
injection
isotope
or
fluorescence
labeled
combined
vagotomy
also
performed
investigate
transmission
from
brain.
data
showed
that,
mice,
transported
brain
mainly
blood
rather
than
vagal
nerve.
Furthermore,
FMT
induced
neuroinflammation,
phenotype
mimics
early
pathology.
Taken
together,
suggests
is
likely
critical
source
can
further
upregulate
production,
thereby
potentially
contributing
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114581 - 114581
Опубликована: Март 24, 2023
Puerarin
is
an
isoflavone
compound
derived
from
Pueraria
lobata
in
traditional
Chinese
medicine.
Accumulating
evidence
has
indicated
that
puerarin
demonstrates
multiple
pharmacological
effects
and
exhibits
treatment
potential
for
various
neurological
disorders.
Based
on
the
latest
research
progress
as
a
neuroprotective
agent,
its
activity,
molecular
mechanism,
therapeutic
application
were
systematically
reviewed
with
emphasis
pre-clinical
studies.
The
related
information
was
extracted
compiled
major
scientific
databases,
including
PubMed,
ScienceDirect,
SpringerLink,
National
Knowledge
Infrastructure,
using
'Puerarin',
'Neuroprotection',
'Apoptosis',
'Autophagy',
'Antioxidant',
'Mitochondria',
'Anti-inflammation'
keywords.
This
review
complied
Preferred
Reporting
Items
Systematic
Reviews
criteria.
Forty-three
articles
met
established
inclusion
exclusion
shown
against
variety
of
disorders,
ischemic
cerebrovascular
disease,
subarachnoid
hemorrhage,
epilepsy,
cognitive
traumatic
brain
injury,
Parkinson's
Alzheimer's
anxiety,
depression,
diabetic
neuropathy,
neuroblastoma/glioblastoma.
anti-apoptosis,
proinflammatory
mediator
inhibitory,
autophagy
regulatory,
anti-oxidative
stress,
mitochondria
protection,
Ca2+
influx
anti-neurodegenerative
activities.
exerts
noticeable
models
disorders
vivo
(animal).
will
contribute
to
development
novel
clinical
drug
candidate
However,
well-designed,
high-quality,
large-scale,
multicenter
randomized
studies
are
needed
determine
safety
utility
patients
As
the
world
population
ages,
new
molecular
targets
in
aging
and
Alzheimer’s
disease
(AD)
are
needed
to
combat
expected
influx
of
AD
cases.
Until
now,
role
RNA
structure
neurodegeneration
has
largely
remained
unexplored.
In
this
study,
we
examined
human
hippocampal
postmortem
tissue
for
formation
G-quadruplexes
(rG4s)
AD.
We
found
that
rG4
immunostaining
strongly
increased
hippocampus
with
both
age
severity.
further
neurons
accumulation
phospho-tau
contained
rG4s,
can
drive
tau
aggregation,
staining
density
depended
on
APOE
genotype
examined.
Combined
previous
studies
showing
dependence
stress
extreme
power
rG4s
at
oligomerizing
proteins,
propose
a
model
which
chronic
is
linked
proteostasis
collapse.
These
morphological
findings
suggest
investigation
critical
avenue
future
treatments
diagnoses.
