V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 8, 2024
Neurosurgical
treatment
for
psychiatric
disorders
has
a
controversial
history.
This
branch
of
neurosurgery
called
by
developer
prefrontal
leucotomy
and
Nobel
prize
laureate
Egaz
Moniz
“psychosurgery”,
was
initially
based
not
on
scientific
researches,
but
enthusiasm
individuals
pressing
social
need.
The
outcome
psychosurgery
regardless
its
clinical
benefits
the
negative
attitude
broad
masses
medical
community,
some
countries
have
banned
–
era
psychopharmacology
come.
However,
patients
suffering
from
severe
course
disorder
are
resistant
to
conservative
treatment.
Over
last
decades,
novel
neuroimaging
methods
neurobiological
researches
considerably
improved
understanding
pathogenesis
validity
surgical
intervention
into
neural
circuits.
In
this
article,
main
stages
history
briefly
reviewed.
Furthermore,
considerations
including
anatomic
target
localization,
possible
complications
major
operations
which
still
in
practice
presented.
new
neurosurgical
techniques
such
as
deep
brain
stimulation
gamma
knife
stereotactic
radiosurgery
were
also
considered.
part
article
is
devoted
ethical,
legal
terminological
issues
neurosurgery.
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 11, 2024
Abstract
Deep
brain
stimulation
(DBS)
modulates
local
and
widespread
connectivity
in
dysfunctional
networks.
Positive
results
are
observed
several
patient
populations;
however,
the
precise
mechanisms
underlying
treatment
remain
unknown.
Translational
DBS
studies
aim
to
answer
these
questions
provide
knowledge
for
advancing
field.
Here,
we
systematically
review
literature
on
involving
models
of
neurological,
developmental
neuropsychiatric
disorders
a
synthesis
current
scientific
landscape
surrounding
this
topic.
A
systematic
analysis
was
performed
following
PRISMA
guidelines.
407
original
articles
were
included.
Data
extraction
focused
study
characteristics,
including
protocol,
behavioural
outcomes,
action.
The
number
published
increased
over
years,
16
rat
13
mouse
transgenic
or
healthy
animals
exposed
external
factors
induce
symptoms.
Most
targeted
telencephalic
structures
with
varying
settings.
outcomes
reported
85.8%
included
studies.
In
psychiatric
neurodevelopmental
disorders,
DBS-induced
effects
associated
changes
monoamines
neuronal
activity
along
mesocorticolimbic
circuit.
For
movement
improves
symptoms
via
modulation
striatal
dopaminergic
system.
dementia
epilepsy
models,
cellular
molecular
aspects
hippocampus
shown
underlie
symptom
improvement.
Despite
limitations
translating
findings
from
preclinical
clinical
settings,
rodent
have
contributed
substantially
our
pathophysiology
disease
mechanisms.
Direct
inhibition/excitation
neural
activity,
whereby
pathological
oscillatory
within
networks,
is
among
major
theories
its
mechanism.
However,
there
fundamental
mechanisms,
optimal
targets
parameters
that
need
be
better
understood
improve
therapy
more
individualized
according
patient’s
predominant
Molecular Psychiatry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Dopamine
modulates
corticostriatal
plasticity
in
both
the
direct
and
indirect
pathways
of
cortico-striato-thalamo-cortical
(CSTC)
loops.
These
gradual
changes
synaptic
strengths
produce
long-lasting
behavioral
responses.
Under
normal
conditions,
these
mechanisms
enable
selection
most
appropriate
responses
while
inhibiting
others.
However,
under
dysregulated
dopamine
including
a
lack
release
or
signaling,
could
lead
to
maladaptive
and/or
inhibition
an
experience-dependent
task-specific
manner.
In
this
review,
we
propose
that
preventing
reversing
such
erasing
aberrant
“memories”
be
disease-modifying
therapeutic
strategy
for
many
neurological
psychiatric
disorders.
We
review
evidence
from
Parkinson’s
disease,
drug-induced
parkinsonism,
L-DOPA-induced
dyskinesia,
obsessive-compulsive
disorder,
substance
use
disorders,
depression
as
well
research
findings
on
animal
disease
models.
Altogether,
studies
allude
emerging
theme
translational
neuroscience
promising
new
directions
therapy
development.
Specifically,
combining
pharmacotherapy
with
deep
brain
stimulation
(DBS)
potentially
cause
desired
specific
neural
circuits.
If
successful,
one
important
advantage
correcting
is
effects
even
after
treatment
has
ended.
will
also
discuss
potential
molecular
targets
approaches,
cAMP
pathway,
proteins
involved
protein
synthesis.
place
special
emphasis
RNA
binding
epitranscriptomic
mechanisms,
they
represent
frontier
distinct
rapidly
simultaneously
altering
synthesis
locally.
Frontiers in Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Янв. 30, 2023
Cocaine’s
addictive
properties
stem
from
its
capacity
to
increase
tonic
extracellular
dopamine
levels
in
the
nucleus
accumbens
(NAc).
The
ventral
tegmental
area
(VTA)
is
a
principal
source
of
NAc
dopamine.
To
investigate
how
high
frequency
stimulation
(HFS)
rodent
VTA
or
core
(NAcc)
modulates
acute
effects
cocaine
administration
on
NAcc
multiple-cyclic
square
wave
voltammetry
(M-CSWV)
was
used.
HFS
alone
decreased
by
42%.
resulted
an
initial
decrease
followed
return
baseline.
following
prevented
cocaine-induced
present
results
suggest
possible
underlying
mechanism
deep
brain
(DBS)
treatment
substance
use
disorders
(SUDs)
and
possibility
treating
SUD
abolishing
release
elicited
other
drugs
abuse
DBS
VTA,
although
further
studies
with
chronic
addiction
models
are
required
confirm
that.
Furthermore,
we
demonstrated
M-CSWV
can
reliably
measure
vivo
both
drug
minimal
artifacts.
Frontiers in Psychiatry,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 23, 2023
Achieving
abstinence
from
drugs
is
a
long
journey
and
can
be
particularly
challenging
in
the
case
of
methamphetamine,
which
has
higher
relapse
rate
than
other
drugs.
Therefore,
real-time
monitoring
patients’
physiological
conditions
before
when
cravings
arise
to
reduce
chance
might
help
improve
clinical
outcomes.
Conventional
treatments,
such
as
behavior
therapy
peer
support,
often
cannot
provide
timely
intervention,
reducing
efficiency
these
therapies.
To
more
effectively
treat
methamphetamine
addiction
real-time,
we
propose
an
intelligent
closed-loop
transcranial
magnetic
stimulation
(TMS)
neuromodulation
system
based
on
multimodal
electroencephalogram–functional
near-infrared
spectroscopy
(EEG-fNIRS)
measurements.
This
review
summarizes
essential
modules
required
for
wearable
efficiently.
First,
advantages
neuroimaging
over
conventional
techniques
analysis
sweat,
saliva,
or
urine
detection
are
discussed.
The
knowledge
implement
wearable,
compact,
user-friendly
systems
with
EEG
fNIRS
reviewed.
features
signals
patients
use
disorder
summarized.
biomarkers
categorized
into
frequency
time
domain
topography-related
parameters,
whereas
fNIRS,
hemoglobin
concentration
variation
functional
connectivity
cortices
described.
Following
this,
applications
two
commonly
used
technologies,
direct
current
TMS,
introduced.
challenges
implementing
TMS
modulation
EEG-fNIRS
summarized,
followed
by
discussion
potential
research
directions
promising
future
this
approach,
including
substance
disorders.
