Neurologijos seminarai,
Год журнала:
2023,
Номер
27(95), С. 34 - 40
Опубликована: Ноя. 8, 2023
Multiple
sclerosis
(MS)
is
a
chronic
disease
of
the
central
nervous
system
(CNS)
most
commonly
diagnosed
in
young
adults.
In
recent
decades,
new
treatments
have
emerged
that
radically
changed
prognosis
and
quality
life
these
patients.
However,
this
has
also
raised
challenges
predicting
course
activity
before
development
neurological
deficits
aggravate
disability
prescribing
appropriate
disease-modifying
therapy
for
individual
patient
timely
manner.
One
possible
solutions
could
help
answer
questions
use
laboratory
biomarkers
MS.
addition
to
oligoclonal
bands
(OGB)
immunoglobulin
G
index,
which
are
already
well
known
clinically
useful
tests,
other
been
discovered
can
assess
inflammatory
neurodegenerative
processes
occurring
CNS.
Kappa
free
light
chains
K-index
identified
as
potential
diagnostic
MS,
with
similar
sensitivity
specificity
OGB.
Some
shown
ability
differentiate
isolated
syndrome
from
MS
identify
clinical
The
concentration
chitinase-3-like
protein
cerebrospinal
fluid
currently
only
biomarker
distinguish
syndrome.
Levels
glial
fibrillary
acidic
blood
serum
primary
progressive
relapsing-remitting
disease.
Serum
neurofilament
chain
levels
considered
monitoring
treatment
efficiency.
This
article
discusses
promising
diagnosis,
activity,
response.
REVISTA DE SAÚDE - RSF,
Год журнала:
2024,
Номер
10(1), С. 1 - 10
Опубликована: Янв. 1, 2024
INTRODUÇÃO:
Os
acometimentos
ocasionados
pela
Esclerose
Múltipla
(EM)
pode
impactar
na
funcionalidade
global
do
indivíduo,
podendo
sua
qualidade
de
vida,
autoestima,
além
da
capacidade
cardiopulmonar.
OBJETIVO:
Avaliar
a
uma
paciente
com
diagnóstico
Múltipla.
MÉTODOS:
Trata-se
um
estudo
tipo
relato
caso,
longitudinal,
descritivo.
Foram
utilizados
os
seguintes
instrumentos
para
coleta
dados:
Escala
Incapacidade
Expandida
(EDSS)
avaliar
gravidade
doença,
Modificada
ao
Impacto
Fadiga
(MFIS)
fadiga,
vida
através
Questionário
Saúde
SF-36,
autoestima
Rosenberg
e
cardiopulmonar
por
meio
Teste
Caminhada
Seis
Minutos
(TC6M).
RESULTADOS:
A
doença
foi
1,5
pontos;
fadiga
pontuada
em
54
pontos,
considerada
boa
75
mostrou
perspectiva
positiva
relação
à
percepção
lidar
desafios
diários
vida.
CONCLUSÃO:
estudada
o
quadro
leve
não
impactada
porém
teve
alteração
Revista română de medicină de laborator,
Год журнала:
2024,
Номер
32(3), С. 245 - 254
Опубликована: Июль 1, 2024
Abstract
Background
Multiple
sclerosis
(MS)
is
a
debilitating
neurological
disease
characterized
by
inflammation,
demyelination,
and
neurodegeneration
in
the
central
nervous
system.
Despite
extensive
research,
pathology
of
MS
remains
incompletely
understood.
Ocrelizumab
(OCRE),
monoclonal
antibody
targeting
CD20-positive
B
cells,
has
shown
efficacy
relapsing
(RR)
primary
progressive
(PP)
MS.
Neurofilaments
(Nf)
are
emerging
biomarkers
neuroaxonal
injury,
reflecting
activity
treatment
response
This
study
aimed
to
assess
impact
OCRE
on
serum
Nf
levels
(NfLs)
RRMS
PPMS
patients
explore
factors
influencing
response.
Methods
A
prospective
included
23
initiating
healthy
controls.
Serum
NfLs
were
quantified
using
ELISA.
Statistical
analyses
evaluated
changes
Results
exhibited
significantly
higher
than
led
significant
reduction
after
one
cycle.
Age
gender
influenced
response,
with
older
females
experiencing
greater
NfL
reduction.
Disability
level
duration
did
not
affect
Both
showed
decreased
treatment.
Conclusions
In
conclusion,
demonstrated
reducing
cycle,
potential
age
gender-related
variations
Larger
longitudinal
studies
needed
further
elucidate
OCRE’s
mechanisms
implications
for
personalized
I P Pavlov Russian Medical Biological Herald,
Год журнала:
2024,
Номер
32(3), С. 433 - 444
Опубликована: Окт. 4, 2024
INTRODUCTION:
Multiple
sclerosis
(MS)
is
a
neurological
demyelinating
disease
of
the
central
nervous
system
manifested
by
pronounced
heterogeneous
symptoms.
Peculiarities
onset,
progression
rate,
and
severity
syndromes
are
different
in
age
groups.
An
increase
frequency
exacerbations,
high
degree
disability
patients
groups
evidence
insufficient
effectiveness
conducted
pathogenetic
therapy.
Due
to
wide
choice
multiple
modifying
drugs
(MSDMDs),
it
important
study
clinical
characteristics
with
MS
aim
further
developing
an
individual
approach
treatment.
AIM:
To
features
therapy
MATERIALS
AND
METHODS:
A
prospective
analysis
data
examination
results
magnetic
resonance
imaging
100
relapsing-remitting
MS,
who
received
outpatient
treatment
Kursk
Regional
Multidisciplinary
Clinical
Hospital,
was
period
stable
remission.
RESULTS:
The
leading
course
were
cerebellar
(78%)
pyramidal
(70%)
syndromes,
besides,
dysfunction
cranial
nerves
(71%)
also
observed.
quantitative
parameter
explicitness
pelvic
disorder
syndrome
predominated
middle-aged
elderly
compared
young
ones
(p
0.001).
Cognitive
disorders
more
often
(14%)
recorded
use
glatiramer
acetate
permitted
reduce
subjects
0.05);
middle
group,
most
effective
timely
transition
from
interferon
beta
ocrelizumab
0.05).
first-line
MSDMDs
(interferon-beta)
demonstrated
low
CONCLUSION:
In
equal
timing
deficit
expressed
than
ones.
First-line
therapy,
particular,
acetate,
patients,
while
recommended
early
second-line
MSDMDs.
Frontiers in Pediatrics,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 5, 2024
Objective
To
study
the
cerebrospinal
fluid
(CSF)
neurofilament
light
chain
(NfL)
in
pediatric
acquired
demyelinating
syndrome
(ADS)
and
its
association
with
factors
of
laboratory
imaging
results.
Methods
We
analyzed
clinical
data
from
children
ADS
collected
May
2020
to
January
2021
at
Department
Neurology
Guangzhou
Women
Children's
Medical
Center.
Enzyme-linked
immunosorbent
assays
were
used
detect
CSF
NfL
patients.
Results
Thirty
patients
(17
male,
13
female)
included
study.
The
most
frequent
diagnosis
was
uncategorized
(36.7%,
11/30),
followed
by
acute
disseminating
encephalomyelitis
(ADEM)
(23.3%,
7/30),
myelin
oligodendrocyte
glycoprotein
antibody-associated
disorder
(MOGAD)
(20.0%,
6/30),
NMO
(6.7%,
2/30),
multiple
sclerosis
(MS)
neuromyelitis
optic
spectrum
disorders
(NMOSD)
2/30).
median
for
first
time
7,425.28
pg/ml
(interquartile
range,
1,273.51,
>10,000
pg/ml).
increase
over
normal
value
(<290.00
people
younger
than
30
years
old)
seen
98.7%
Patients
divided
into
ADS,
ADEM,
MOGAD,
MS/NMO/NMOSD
groups,
no
significant
difference
between
each
group.
positively
correlated
immunoglobulin
(Ig)
G
(
ρ
=
0.473)
IgE
0.366).
However,
did
not
correlate
white
blood
count
protein.
Furthermore,
there
oligoclonal
bands
positive
without.
negatively
interferon
γ
−0.501),
CD45
+
CD3
T
−0.466),
CD4
CD8
cells
−0.521).
it
CD19
B
cells.
cerebral
matter
lesions
MRI
higher
Moreover,
number
brain
locations
0.362).
Nine
underwent
detections
NfL,
their
last
detection
significantly
different
first.
Conclusions
increases
can
be
a
biomarker
neuro-axonal
injury
good
indication
extent
lesions.
Neurologijos seminarai,
Год журнала:
2023,
Номер
27(95), С. 34 - 40
Опубликована: Ноя. 8, 2023
Multiple
sclerosis
(MS)
is
a
chronic
disease
of
the
central
nervous
system
(CNS)
most
commonly
diagnosed
in
young
adults.
In
recent
decades,
new
treatments
have
emerged
that
radically
changed
prognosis
and
quality
life
these
patients.
However,
this
has
also
raised
challenges
predicting
course
activity
before
development
neurological
deficits
aggravate
disability
prescribing
appropriate
disease-modifying
therapy
for
individual
patient
timely
manner.
One
possible
solutions
could
help
answer
questions
use
laboratory
biomarkers
MS.
addition
to
oligoclonal
bands
(OGB)
immunoglobulin
G
index,
which
are
already
well
known
clinically
useful
tests,
other
been
discovered
can
assess
inflammatory
neurodegenerative
processes
occurring
CNS.
Kappa
free
light
chains
K-index
identified
as
potential
diagnostic
MS,
with
similar
sensitivity
specificity
OGB.
Some
shown
ability
differentiate
isolated
syndrome
from
MS
identify
clinical
The
concentration
chitinase-3-like
protein
cerebrospinal
fluid
currently
only
biomarker
distinguish
syndrome.
Levels
glial
fibrillary
acidic
blood
serum
primary
progressive
relapsing-remitting
disease.
Serum
neurofilament
chain
levels
considered
monitoring
treatment
efficiency.
This
article
discusses
promising
diagnosis,
activity,
response.
