Preventive and Therapeutic Effects of Intracerebroventricular Administration of Maresin-1 on Lipopolysaccharide-Induced Depression-Like Behaviors in Mice
Biological and Pharmaceutical Bulletin,
Год журнала:
2025,
Номер
48(1), С. 6 - 10
Опубликована: Янв. 10, 2025
Enhanced
inflammatory
and
immune
responses
have
been
observed
in
patients
with
major
depressive
disorder,
pointing
to
anti-inflammatory
substances
as
potential
seeds
for
developing
novel
antidepressants.
Omega-3
polyunsaturated
fatty
acid
metabolites,
such
resolvin
D
E
series,
maresins,
protectins
(collectively
known
specialized
pro-resolving
mediators)
demonstrate
effects.
This
study
examined
the
antidepressant-like
effects
of
maresin-1
(MaR1)
on
lipopolysaccharide
(LPS)-induced
depression-like
behaviors
mice.
Using
tail
suspension
test
(TST)
forced
swim
(FST),
we
assessed
26
28
h
after
intraperitoneal
injection
LPS
(0.8
mg/kg),
respectively.
An
open
field
(OFT)
was
also
conducted
evaluate
locomotor
activity
24
injection.
Intracerebroventricular
(i.c.v.)
MaR1
(10
ng/mouse)
immediately
challenge
mitigated
increased
immobility
time
TST
FST,
without
affecting
OFT,
indicating
preventive
LPS-induced
behaviors.
Furthermore,
i.c.v.
23
reduced
both
tests,
underscoring
its
therapeutic
potential.
These
findings
suggest
that
could
be
a
promising
seed
Язык: Английский
Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen
Journal of Pharmacological Sciences,
Год журнала:
2024,
Номер
154(4), С. 279 - 293
Опубликована: Фев. 15, 2024
Despite
the
importance
of
lipid
mediators
in
stress
and
depression
their
link
to
inflammation,
influence
on
these
role
inflammation
is
not
fully
understood.
This
study
used
RNA-seq,
LC-MS/MS,
flow
cytometry
analyses
a
mouse
model
subjected
chronic
social
defeat
explore
effects
acute
mediators,
gene
expression,
cell
population
bone
marrow
spleen.
In
marrow,
induced
sustained
transition
from
lymphoid
myeloid
cells,
accompanied
by
corresponding
changes
expression.
change
was
associated
with
decreased
levels
15-deoxy-d12,14-prostaglandin
J2,
mediator
that
inhibits
inflammation.
spleen,
also
lymphoid-to-myeloid
transition,
albeit
transiently,
alongside
expression
indicative
extramedullary
hematopoiesis.
These
were
linked
lower
12-HEPE
resolvins,
both
critical
for
inhibiting
resolving
Our
findings
highlight
significant
anti-inflammatory
pro-resolving
immune
responses
paves
way
understanding
how
contribute
mechanisms
depression.
Язык: Английский
Neohesperidin exerts antidepressant-like effect via the mechanistic target of rapamycin complex 1 in the medial prefrontal cortex in male mice
Journal of Pharmacological Sciences,
Год журнала:
2024,
Номер
156(2), С. 82 - 85
Опубликована: Июль 30, 2024
Neohesperidin,
a
citrus
flavonoid,
shows
potential
for
activating
the
mechanistic
target
of
rapamycin
complex
1
(mTORC1).
Here,
antidepressant-like
effect
neohesperidin
was
examined
in
male
ICR
mice
(naïve
and
treated
repeatedly
with
prednisolone,
synthetic
glucocorticoid,
which
induces
depression-like
behavior).
Oral
administration
exerted
an
forced
swim
test
h
post-treatment,
naïve
mice;
this
no
longer
observed
at
24
h.
Neohesperidin
also
reversed
prednisolone-induced
behavior.
This
blocked
by
infusing
rapamycin,
mTORC1
inhibitor,
into
medial
prefrontal
cortex.
may
rapidly
produce
effect.
Язык: Английский
Stereochemistry and functions of the new cysteinyl‐resolvin, 4S,5R‐RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes
American Journal of Hematology,
Год журнала:
2023,
Номер
98(7), С. 1000 - 1016
Опубликована: Май 4, 2023
Abstract
Specialized
pro‐resolving
lipid
mediators
play
key
functions
in
the
resolution
of
acute
inflammatory
response.
Herein,
we
elucidate
stereochemical
structure
new
4S,5R‐RCTR1,
a
cysteinyl‐resolvin,
recently
uncovered
human
leukocytes
incubated
with
4S,5S‐epoxy‐resolvin
intermediate,
using
liquid
chromatography–tandem
mass
spectrometry
(LC–MS/MS)
and
ultra‐violet
(UV)
spectrophotometry.
With
this
approach,
physical
properties
mediator
prepared
by
total
organic
synthesis
were
matched
to
enzymatically
produced
biogenic
material.
In
addition,
confirmed
potent
biological
actions
4S,5R‐RCTR1
M2‐like
macrophage
phagocytosis
live
bacteria,
efferocytosis
apoptotic
neutrophils,
erythrophagocytosis
senescent
red
blood
cells
concentration‐dependent
manner
from
0.1
10
nM.
Taken
together,
these
results
establish
complete
stereochemistry
as
5R‐glutathionyl‐4S,17S‐dihydroxy‐6E,8E,10Z,13Z,15E,19Z‐docosahexaenoic
acid
give
evidence
its
novel
bioactivities
phagocyte
responses.
Moreover,
they
confirm
extend
stereoselective
isolated
phagocytes
interest
inflammation.
Язык: Английский
Neuron‐specific deletion of VEGF or its receptor Flk‐1 occludes the antidepressant‐like effects of desipramine and fluoxetine in mice
Neuropsychopharmacology Reports,
Год журнала:
2023,
Номер
44(1), С. 246 - 249
Опубликована: Ноя. 13, 2023
Abstract
Vascular
endothelial
growth
factor
(VEGF)
signaling
is
known
to
be
involved
in
the
antidepressant‐like
effects
of
conventional
antidepressants,
such
as
desipramine
(DMI),
a
tricyclic
antidepressant,
and
fluoxetine
(FLX),
selective
serotonin
reuptake
inhibitor;
however,
precise
role
neuronal
VEGF
mediating
these
remains
unclear.
Using
mice
with
excitatory
neuron‐specific
deletion
its
receptor,
fetal
liver
kinase
1
(Flk‐1)
forebrain,
we
examined
forebrain
or
Flk‐1
on
repeated
DMI
chronic
FLX
administration
forced
swim
test
(FST).
Repeated
intraperitoneal
(i.p.)
injections
(10,
10,
20
mg/kg
at
24,
4,
h
before
FST,
respectively)
significantly
decreased
immobility
control
mice;
this
effect
was
completely
blocked
deletion.
Although
treatment
(18
mg/kg/day,
i.p.)
did
not
impact
day
after
22nd
injection,
reduced
preswim
23rd
injection.
However,
deletion,
increased
failed
produce
effects.
Collectively,
findings
indicate
that
VEGF–Flk‐1
contributes
actions
antidepressants.
Язык: Английский
Resolvin E1 and Inhibition of BLT2 Signaling Attenuate the Inflammatory Response and Improve One-Lung Ventilation-Induced Lung Injury
Immunological Investigations,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Сен. 4, 2024
One-lung
ventilation
(OLV)
is
a
prevalently
used
technique
to
sustain
intraoperative
pulmonary
function.
Resolvin
E1
(RvE1),
specialized
pro-resolving
lipid
mediator,
accelerates
the
resolution
of
inflammation
in
lungs.
However,
its
therapeutic
effects
on
OLV-induced
lung
injury
remain
unclear.
Язык: Английский
Antidepressant-like effects of tomatidine and tomatine, steroidal alkaloids from unripe tomatoes, via activation of mTORC1 in the medial prefrontal cortex in lipopolysaccharide-induced depression model mice
Nutritional Neuroscience,
Год журнала:
2023,
Номер
27(8), С. 795 - 808
Опубликована: Сен. 13, 2023
Ketamine,
an
Язык: Английский
Elucidation of the Mechanisms Underlying the Rapid Antidepressant Actions of Ketamine and Search for Possible Candidates for Novel Rapid-acting Antidepressants
YAKUGAKU ZASSHI,
Год журнала:
2023,
Номер
143(9), С. 713 - 720
Опубликована: Авг. 31, 2023
Ketamine,
an
N-methyl-D-aspartate
receptor
antagonist,
elicits
swift
antidepressant
effects
even
in
subjects
with
treatment-resistant
depression.
Nonetheless,
owing
to
the
serious
adverse
associated
ketamine,
including
psychotomimetic
effects,
development
of
safer
rapid-acting
antidepressants
is
imperative.
The
elucidation
mechanisms
underlying
ketamine
will
facilitate
advancement
these
alternative
treatments.
Previous
preclinical
studies
have
indicated
that
properties
are
mediated
by
activity-dependent
release
brain-derived
neurotrophic
factor
(BDNF)
and
subsequent
activation
mechanistic
target
rapamycin
complex
1
(mTORC1)
medial
prefrontal
cortex
(mPFC).
Our
research
has
demonstrated
exerts
antidepressant-like
inducing
vascular
endothelial
growth
(VEGF)
insulin-like
factor-1
(IGF-1)
mPFC.
Furthermore,
our
recent
findings
revealed
resolvins
(RvD1,
RvD2,
RvE1,
RvE2,
RvE3),
which
bioactive
lipid
mediators
derived
from
docosahexaenoic
eicosapentaenoic
acids,
exhibit
rodent
models.
Notably,
RvD1,
RvE1
require
mTORC1
activation.
Moreover,
intranasal
administration
rapid
through
BDNF
VEGF
mPFC
hippocampal
dentate
gyrus
(DG),
as
well
mPFC,
albeit
not
DG.
These
strongly
suggest
resolvins,
particularly
hold
promise
prospective
candidates
for
novel,
safer,
antidepressants.
Язык: Английский
レゾルビンE1によるうつ病治療の可能性
Folia Pharmacologica Japonica,
Год журнала:
2024,
Номер
159(4), С. 210 - 213
Опубликована: Июнь 30, 2024
モノアミン仮説に基づく従来の抗うつ薬は即効性がなく,3割以上の患者が治療抵抗性を示す.一方,NMDA受容体阻害薬ケタミンは,治療抵抗性うつ病患者に即効性かつ持続性の抗うつ作用を示すことが明らかにされている.しかし,ケタミンには依存性や統合失調症様症状といった重大な副作用があるため,抗うつ薬としての使用には大きな制約を伴う.そのため,より安全性の高い新たな即効性抗うつ薬の開発が求められている.我々は,その候補としてドコサヘキサエン酸やエイコサペンタエン酸の活性代謝物であるレゾルビン類に注目し,これらがうつ病モデルマウスに対して抗うつ様作用を示すことを明らかにしてきた.本稿では,レゾルビン類のなかで最も低用量で抗うつ様作用を示したレゾルビンE1(RvE1)に焦点を当て,その抗うつ特性と作用メカニズムについて紹介する.まずRvE1側脳室内投与が,リポポリサッカライド誘発うつ病モデルマウスに対して抗うつ様作用を示し,この作用にケメリン受容体ChemR23活性化が関与する可能性を明らかにした.RvE1側脳室内投与は,慢性疼痛モデルマウスや三環系抗うつ薬の急性投与に抵抗性を示すプレドニゾロン反復投与誘発うつ病モデルマウスにも抗うつ様作用を示した.また,RvE1の抗うつ様作用には,内側前頭前野(mPFC)や背側海馬歯状回(DG)が関与することを見出した.さらに,RvE1経鼻投与が,ケタミンと類似のメカニズムで抗うつ様作用を示すことを明らかにした.すなわち,RvE1はmPFCおよび背側DGにおける活動依存的なBDNFおよびVEGF遊離亢進と,mPFCにおけるmechanistic
target
of
rapamycin
complex
1活性化を介して即効性かつ持続性の抗うつ様作用を示す.以上の知見から,RvE1が新しい即効性抗うつ薬のリード化合物になると期待される.
Omega-3 Fatty Acids from Fish: A Novel Approach in Cancer Therapy
Biosciences Biotechnology Research Asia,
Год журнала:
2024,
Номер
21(4), С. 1303 - 1317
Опубликована: Дек. 20, 2024
ABSTRACT:
Omega-3
fatty
acids
(OFAs)
are
essential
macromolecules
which
frequently
used
to
provide
nutritional
support
in
cancer
patients.
They
have
been
recognised
as
immunonutrients,
they
play
important
role
strengthening
the
immune
responses
against
various
disease
including
cancer.
OFAs
such
eicosapentaenoic
acid
(EPA)
and
docosahexaenoic
(DHA)
shown
great
promise
prevention
its
management.
Epidemiological
studies
demonstrated
a
correlation
between
fish
consumption
reduced
risk,
evidence
suggests
that
increased
is
linked
lower
risk
of
cancer,
potentially
due
high
levels
bioactive
fish.
Experimental
revealed
capable
modulating
cell
signalling
pathways,
gene
expression
influencing
membrane
composition,
can
promote
apoptosis
inhibition
proliferation.
Moreover,
antioxidant
property
has
reported
oxidative
stress-induced
DNA
damage.
Apart
from
anticancer
properties
also
good
results
managing
related
complications
inflammation,
gastrointestinal
reactions,
anorexia-cachexia
syndrome.
Several
showed
their
efficacy
relieving
associated
cachexia
anorexia
syndrome
with
significant
improvements
weight
loss.
OFA
supplementation
antidepressant
enhanced
well-being
individuals.
Despite
promising
effects
many
challenges
remain
like
optimal
dose
determination,
variable
impact
across
types
risks
intake.
Further
large
scale
randomized
control
trials
(RCTs)
needed
assisted
treatment.
Язык: Английский