Time course of lead-induced dyslipidemia in male albino rats DOI Creative Commons

Esther Omugha Abam,

Adedoja Dorcas Wusu, Olabisi Ogunrinola

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 19, 2024

Abstract Background Lead has been shown to induce dyslipidemia in rats although the attendant mechanisms have not clearly elucidated. Methods In order investigate time-course of lead-induced perturbations lipid metabolism, male Wistar were exposed 200, 300 and 400 ppm lead as acetate their drinking water for 4, 8 12 weeks. Control animals received distilled same exposure times after which blood, liver, kidney, brain, heart lungs removed from analyzed dynamics spectrophotometrically. Results accumulated organs following descending order: kidney > liver brain lungs. Lead-induced inhibition reverse cholesterol transport was both time-dependent well dose-dependent at 4 weeks evidenced by decrease HDL (17% 4-week ppm, 35, 43 49% doses respectively weeks). Free fatty acids (FFAs) plasma displayed a hormetic-like response with lowest dose instigating 51% FFA while 2-fold 1.5-fold increases respectively. Increases erythrocyte also observed 200 all Increased hepatic, renal cholesterogenesis generally highest occurring organs. Hepatic, renal, cardiac pulmonary phospholipidosis times. Cardiac decreased triacyglycerols increased Hepatic HMG-CoA reductase activities up-regulated most increase (35%) Positive correlations between (r = 0.476, p 0.01), 0.498, 0.01) negative correlation blood -0.523, 0.01). Conclusion These findings indicate that may be mediated through up-regulation activity, enhanced resulting availability FFA.

Язык: Английский

Time course of lead-induced dyslipidemia in male albino rats DOI Creative Commons

Esther Omugha Abam,

Adedoja Dorcas Wusu, Olabisi Ogunrinola

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 19, 2024

Abstract Background Lead has been shown to induce dyslipidemia in rats although the attendant mechanisms have not clearly elucidated. Methods In order investigate time-course of lead-induced perturbations lipid metabolism, male Wistar were exposed 200, 300 and 400 ppm lead as acetate their drinking water for 4, 8 12 weeks. Control animals received distilled same exposure times after which blood, liver, kidney, brain, heart lungs removed from analyzed dynamics spectrophotometrically. Results accumulated organs following descending order: kidney > liver brain lungs. Lead-induced inhibition reverse cholesterol transport was both time-dependent well dose-dependent at 4 weeks evidenced by decrease HDL (17% 4-week ppm, 35, 43 49% doses respectively weeks). Free fatty acids (FFAs) plasma displayed a hormetic-like response with lowest dose instigating 51% FFA while 2-fold 1.5-fold increases respectively. Increases erythrocyte also observed 200 all Increased hepatic, renal cholesterogenesis generally highest occurring organs. Hepatic, renal, cardiac pulmonary phospholipidosis times. Cardiac decreased triacyglycerols increased Hepatic HMG-CoA reductase activities up-regulated most increase (35%) Positive correlations between (r = 0.476, p 0.01), 0.498, 0.01) negative correlation blood -0.523, 0.01). Conclusion These findings indicate that may be mediated through up-regulation activity, enhanced resulting availability FFA.

Язык: Английский

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