Time course of lead-induced dyslipidemia in male albino rats
Abstract
Background
Lead
has
been
shown
to
induce
dyslipidemia
in
rats
although
the
attendant
mechanisms
have
not
clearly
elucidated.
Methods
In
order
investigate
time-course
of
lead-induced
perturbations
lipid
metabolism,
male
Wistar
were
exposed
200,
300
and
400
ppm
lead
as
acetate
their
drinking
water
for
4,
8
12
weeks.
Control
animals
received
distilled
same
exposure
times
after
which
blood,
liver,
kidney,
brain,
heart
lungs
removed
from
analyzed
dynamics
spectrophotometrically.
Results
accumulated
organs
following
descending
order:
kidney
>
liver
brain
lungs.
Lead-induced
inhibition
reverse
cholesterol
transport
was
both
time-dependent
well
dose-dependent
at
4
weeks
evidenced
by
decrease
HDL
(17%
4-week
ppm,
35,
43
49%
doses
respectively
weeks).
Free
fatty
acids
(FFAs)
plasma
displayed
a
hormetic-like
response
with
lowest
dose
instigating
51%
FFA
while
2-fold
1.5-fold
increases
respectively.
Increases
erythrocyte
also
observed
200
all
Increased
hepatic,
renal
cholesterogenesis
generally
highest
occurring
organs.
Hepatic,
renal,
cardiac
pulmonary
phospholipidosis
times.
Cardiac
decreased
triacyglycerols
increased
Hepatic
HMG-CoA
reductase
activities
up-regulated
most
increase
(35%)
Positive
correlations
between
(r
=
0.476,
p
0.01),
0.498,
0.01)
negative
correlation
blood
-0.523,
0.01).
Conclusion
These
findings
indicate
that
may
be
mediated
through
up-regulation
activity,
enhanced
resulting
availability
FFA.

Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июнь 19, 2024
Язык: Английский