Journal of Neuroimmunology,
Год журнала:
2024,
Номер
394, С. 578421 - 578421
Опубликована: Июль 27, 2024
Niacin
was
found
in
the
lysolecithin
model
of
multiple
sclerosis
(MS)
to
promote
phagocytic
clearance
debris
and
enhance
remyelination.
Lysolecithin
lesions
have
prominent
microglia/macrophages
but
lack
lymphocytes
that
populate
plaques
MS
or
its
experimental
autoimmune
encephalomyelitis
(EAE)
model.
Thus,
current
study
assessed
efficacy
niacin
EAE.
We
inconsistently
affects
EAE
clinical
score,
largely
does
not
ameliorate
neuropathology.
In
culture,
enhances
phagocytosis
by
macrophages,
reduce
T
cell
proliferation.
suggest
studies
for
potential
remyelination
should
include
a
therapeutic
targets
adaptive
immunity.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 16, 2024
The
long-term
health
impacts
of
niacin
are
still
debated,
and
the
association
between
dietary
mortality
risk
in
populations
hasn't
been
extensively
explored.
This
study
included
26,746
US
adults
aged
20
years
or
older
from
National
Health
Nutrition
Examination
Survey
2003–2018,
with
a
median
follow-up
9.17
years.
During
this
period,
there
were
3,551
all-cause
deaths,
including
1,096
cardiovascular
deaths.
Cox
models
used
to
compare
hazard
ratios
(HRs)
for
among
participants
grouped
into
different
intake
quartiles.
Participants
highest
had
lower
(HR
0.74,
95%CI
0.63–0.86)
compared
those
lowest
quartile.
For
mortality,
HR
was
0.73
(95%CI
0.57–0.95)
A
dose-response
relationship
revealed
by
restricted
cubic
spline.
Subgroup
analysis
showed
significant
interaction
diabetes
concerning
(P
=
0.046).
In
population-based
cohort
study,
higher
correlates
adults.
influence
on
appears
be
more
non-diabetic
individuals
diabetes.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
This
study
investigates
the
impact
of
a
high-fat-rich
diet
(HFRD)
on
behavioral,
biochemical,
neurochemical,
and
histopathological
studies
using
hypothalamus
rats
following
niacin
(NCN)
administration.
The
were
divided
into
HFRD
normal
(ND)-fed
groups
administered
selected
doses
NCN,
i.e.,
25
mg/mL/kg
(low
dose)
50
(high
dose),
for
8
weeks.
grouping
male
(n
=
8)
was
as
follows:
(i)
Vehicle
(Veh)
+
ND;
(ii)
ND
NCN
dose);
(iii)
(iv)
Veh
HFRD;
(v)
(vi)
dose).
Behavioral
tests
assessed
depression-like
symptoms
spatial
memory;
after
that,
isolated
various
analyses
sacrificed
animals.
at
both
decreased
food
intake
growth
rate
in
demonstrated
antidepressant
memory-enhancing
effects.
HFRD-induced
oxido-neuroinflammation
with
NCN.
decreases
serotonergic
neurotransmission,
5-HT1A
receptor
expression,
morphological
alterations
rat's
normalized
by
In
conclusion,
potential
antioxidant
neuromodulator,
can
normalize
feeding
behavior
produce
memory-improving
effects
rat
model
obesity
intake.
International Journal of Women s Health,
Год журнала:
2024,
Номер
Volume 16, С. 2209 - 2219
Опубликована: Дек. 1, 2024
This
study
aimed
to
explore
the
association
between
dietary
niacin
intake
and
rheumatoid
arthritis
(RA)
in
American
women
through
National
Health
Nutrition
Examination
Survey
(NHANES)
database.
Journal of Neuroimmunology,
Год журнала:
2024,
Номер
394, С. 578421 - 578421
Опубликована: Июль 27, 2024
Niacin
was
found
in
the
lysolecithin
model
of
multiple
sclerosis
(MS)
to
promote
phagocytic
clearance
debris
and
enhance
remyelination.
Lysolecithin
lesions
have
prominent
microglia/macrophages
but
lack
lymphocytes
that
populate
plaques
MS
or
its
experimental
autoimmune
encephalomyelitis
(EAE)
model.
Thus,
current
study
assessed
efficacy
niacin
EAE.
We
inconsistently
affects
EAE
clinical
score,
largely
does
not
ameliorate
neuropathology.
In
culture,
enhances
phagocytosis
by
macrophages,
reduce
T
cell
proliferation.
suggest
studies
for
potential
remyelination
should
include
a
therapeutic
targets
adaptive
immunity.
