Modulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy

Cell Death and Disease, Год журнала: 2024, Номер 15(5)

Опубликована: Май 1, 2024

Abstract The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression efficacy of immunotherapy. This review comprehensively discusses key factors regulating ECM remodeling, including activation cancer-associated fibroblasts accumulation crosslinking proteins. Furthermore, it provides detailed exploration how influences behaviors both immune cells. Significantly, impact on response to various immunotherapy strategies, such checkpoint blockade, adoptive cell therapy, oncolytic virus therapeutic vaccines, thoroughly examined. also addresses challenges translating research findings into clinical practice, highlighting need for more precise biomaterials that accurately mimic development novel strategies. insights offered aim guide future research, with potential enhance effectiveness modalities.

Язык: Английский

A green-based approach for noninvasive skin rejuvenation: Potential application of hyaluronic acid

Environmental Research, Год журнала: 2023, Номер 234, С. 116467 - 116467

Опубликована: Июнь 20, 2023

Язык: Английский

Preparation of chitosan-hyaluronic acid microcapsules and its dynamic release behavior analysis in a 3D-printed microchannel system: Exploration and verification

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 133031 - 133031

Опубликована: Июнь 12, 2024

Язык: Английский