BioNanoScience, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 23, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134962 - 134962
Опубликована: Авг. 22, 2024
Язык: Английский
Процитировано
9
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101457 - 101457
Опубликована: Янв. 5, 2025
Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the blood-brain barrier (BBB), drug delivery for CNS is extremely challenging. Nano-delivery systems can overcome limitations BBB deliver drugs CNS, improve ability target brain provide potential therapeutic methods diseases. At same time, choice different (bypassing or crossing BBB) further optimize effect nano-drug system. This article reviews nano-delivery way enters brain. Different kinds nanoparticles were discussed in depth.
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106623 - 106623
Опубликована: Янв. 1, 2025
Процитировано
1
BioNanoScience, Год журнала: 2025, Номер 15(2)
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
0
BMC Chemistry, Год журнала: 2025, Номер 19(1)
Опубликована: Март 8, 2025
Solidified reverse micellar technology and surface-modification are promising techniques for improving the biopharmaceutical properties of poorly water-soluble drugs such as artemether, a first-line antimalarial drug. Thus, aim this study was to develop evaluate artemether-loaded chitosan-coated solid lipid nanoparticles (SLNs) based on solidified solution (SRMS) improved oral malaria therapy. Artemether-loaded unloaded SLNs were prepared from optimized SRMS (consisting Phospholipon® 90G Compritol® ATO 888 at 3:7 ratio) with or without chitosan by high-shear melt-homogenization, thereafter characterized physicochemical performance, stability, safety activity using Plasmodium berghei-infected mice. Results showed both smooth irregular particles layer polymer coating in chitosan-modified SLNs, increased drug amorphization well compatibility excipients employed formulations. The formulation stable nanomeric (size 292.90 ± 5.01 nm, polydispersity index 0.191 0.09, zeta-potential + 32.50 1.58 mV) good encapsulation efficiency (82.03%), demonstrated minimal toxicity Caco-2 cells, exhibited controlled release compared fast artemether suspension gave significantly (p < 0.05) greater than suspension. SRMS-based can be pursued novel alternative treatment.
Язык: Английский
Процитировано
0
Journal of Dispersion Science and Technology, Год журнала: 2025, Номер unknown, С. 1 - 33
Опубликована: Апрель 28, 2025
Язык: Английский
Процитировано
0
Neurochemical Research, Год журнала: 2024, Номер 50(1)
Опубликована: Ноя. 22, 2024
Abstract Exposure to rotenone results in similar pathophysiological features as Parkinson’s disease. Inflammation and oxidative stress are essential PD pathogenesis. Maresin-1 has potent anti-inflammatory properties promotes the regression of inflammation function. The current study aimed evaluate protective effects (MaR1) (ROT)-induced whether this role is associated with initiation Janus kinase (JAK)-signal transducers activator transcription (STAT) signaling pathway. Thirty male Wister rats were classified into control, ROT-treated, ROT + MaR1-treated groups. Rats underwent rotarod, open field, grip strength, stepping tests part their motor behavioral evaluation. Serum glial cell-derived neurotrophic factor (GDNF) striatal dopamine, acetylcholine, malondialdehyde (MDA), reduced glutathione (GSH), TNF-α, IL-6, IL-1β evaluated. Expression JAK1 STAT3 genes was assessed striatum. Then, tissue subjected histological immunohistochemical evaluation for caspase-3, GFAP, NF-kB. administrated group showed significant impairment. This accompanied by levels GDNF dopamine increased well augmented inflammatory biomarkers antioxidant activity. Inflammatory pathways (JAK1/STAT3, NF-kB) upregulated. Histopathological changes upregulation GFAP immunopositive reaction observed. Remarkably, MaR1 treatment effectively alleviated behavior, histopathological changes, biochemical alterations induced ROT. exerts against ROT-induced its anti-inflammatory, antiapoptotic, properties. mechanisms action may involve modulation such JAK/STAT.
Язык: Английский
Процитировано
3
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 12343 - 12368
Опубликована: Ноя. 1, 2024
The intranasal (IN) route of drug delivery can effectively penetrate the blood-brain barrier and deliver drugs directly to brain for treatment central nervous system (CNS) disorders via intra-neuronal or extra-neuronal pathways. This approach has several advantages, including avoidance first-pass metabolism, high bioavailability, ease administration, improved patient compliance. In recent years, an increasing number studies have been conducted using encapsulated in solid lipid nanoparticles (SLNs) nanostructured carriers (NLCs), delivering them IN pathway. SLNs are first-generation nanocarriers, known their excellent biocompatibility, drug-loading capacity, remarkable stability. NLCs, regarded as second-generation SLNs, not only retain advantages but also exhibit enhanced stability, preventing leakage during storage. this review, we examined vivo between 2019 2024 that used NLCs address CNS route. By statistical methods evaluate pharmacokinetic parameters, found markedly accumulation targeting within brain. Additionally, pharmacodynamic evaluations indicated method substantially therapeutic effectiveness alleviating symptoms rat models diseases. addition, enhancing efficacy nose-to-brain discussed, well advances clinical trials regarding NLCs.
Язык: Английский
Процитировано
2
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Cannabidiol (CBD) is a natural product isolated from the Cannabis sativa plant that was approved by United States Food and Drug Administration (US FDA) for treatment of resistant epilepsy. Despite its therapeutic potential, CBD's clinical application limited poor aqueous solubility low oral bioavailability. The primary aim this research to enhance bioavailability CBD developing nanostructured lipid carriers (NLCs) using conventional hot homogenization method (CHH). In current study, nine NLC formulations were developed through CHH, which, NLC5 emerged as most promising formulation, exhibiting high entrapment efficiency (99.23%), particle size 207 nm, polydispersity index 0.19, zeta potential -26 mV. Additionally, drug release testing showed rate more than 90% within 15 min, indicating an enhancement dissolving compared pure CBD. in vivo pharmacokinetic study formulation 27% Furthermore, Stability studies conducted at 4 °C 25 on over three months, revealed consistent parameters, underscoring robustness formulation. conclusion, successful CBD-loaded NLCs resulted improved rate, enhanced CBD, maintained stability, making it approach effective delivery
Язык: Английский
Процитировано
2
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Март 14, 2024
Abstract Entacapone is utilized as an adjunct to levodopa therapy for the treatment of Parkinson's syndrome. According Biopharmaceutics Classification System, it classified a class IV drug. The solubility substance can be enhanced by utilizing nanoemulsion, which also effectively traverse blood-brain barrier owing its nanoscale dimensions. formulation various proportions Capmul Medium Chain Mono and Diglycerides oil phase, Pluronic F127, Phospholipin 90 hydrophilic lipophilic surfactants. Optimization was performed using 3 2 factorial designs in Design Expert ® 8.0.5.2 software, incorporating mixing speed, time, sonication parameters. nanoemulsion exhibited average particle size 120.8±1.9nm, with low polydispersity index 0.144, indicating uniform globule size. zeta potential suggested good stability, while XRD pattern indicated decreased drug crystallinity. TEM images confirm that particles falls within range 120–150 nm there no evidence aggregation. released at rate 80.33±0.92% 8 hours. current study demonstrates enhancements stability formulated nanoemulsions designed oral delivery.
Язык: Английский
Процитировано
0