Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 203 - 252
Опубликована: Ноя. 29, 2024
Язык: Английский
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Авг. 28, 2024
Abstract Exosomes are extracellular nanovesicles secreted by all cell types and have been studied to understand treat many human diseases. involved in numerous physiological pathological processes, intercellular communication, the transfer of substances. Over years, several studies explored mammalian-derived exosomes for therapeutic diagnostic uses. Only recently plant-derived vesicles (EVs) attracted attention their ability overcome defects associated with using vesicles, such as safety scale-up issues. The ease large-scale production, low toxicity, immunogenicity, efficient cellular uptake, high biocompatibility, stability these make them attractive drug delivery systems. In addition, native contents proteins, miRNAs secondary metabolites could be exploited pharmaceutical applications combination other drugs. present review intends provide adequate tools studying developing systems based on EVs. Therefore, indications concerning extraction methods, characterisation, loading will offered. Their biological composition content also reported. Finally, current nanocarriers pharmacologically active substances shown. Graphical
Язык: Английский
Процитировано
7
Pharmacological Research, Год журнала: 2024, Номер 204, С. 107202 - 107202
Опубликована: Май 3, 2024
Plant-derived extracellular vesicles (PDEV) constitute nanoscale entities comprising lipids, proteins, nucleic acids and various components enveloped by the lipid bilayers of plant cells. These play a crucial role in facilitating substance information transfer not only between cells but also across different species. Owing to its safety, stability, abundance raw materials, this has found extensive utilization recent years within research endeavors aimed at treating diseases. This article provides an overview pathways biological characteristics PDEV, along with prevalent methods employed for isolation, purification, storage. Furthermore, we comprehensively outline therapeutic implications diverse sources PDEV musculoskeletal system disorders. Additionally, explore as platforms engineering drug carriers, aiming delve deeper into significance potential contributions realm system.
Язык: Английский
Процитировано
6
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Авг. 13, 2024
Immune dysfunction in early pregnancy including overactivation of cytotoxic CD16
Язык: Английский
Процитировано
4
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9147 - 9147
Опубликована: Авг. 23, 2024
Respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, lung cancer, and coronavirus pneumonia, present a major global health challenge. Current diagnostic therapeutic options for these diseases are limited, necessitating the urgent development of novel biomarkers strategies. In recent years, microRNAs (miRNAs) within extracellular vesicles (EVs) have received considerable attention due to their crucial role in intercellular communication progression. EVs membrane-bound structures released by cells into environment, encapsulating variety biomolecules such as DNA, RNA, lipids, proteins. Specifically, miRNAs EVs, known EV-miRNAs, facilitate regulating gene expression. The expression levels can reflect distinct states significantly influence immune cell function, airway inflammation, remodeling, proliferation, angiogenesis, epithelial-mesenchymal transition, other pathological processes. Consequently, EV-miRNAs profound impact on onset, progression, responses respiratory with great potential management. Synthesizing current understanding COPD, this review aims explore targets examine prospects diagnosis treatment diseases.
Язык: Английский
Процитировано
4
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 9871 - 9887
Опубликована: Сен. 1, 2024
Pathological scarring results from aberrant cutaneous wound healing due to the overactivation of biological behaviors human skin fibroblasts, characterized by local inordinate inflammation, excessive extracellular matrix and collagen deposition. Yet, its underlying pathogenesis opinions vary, which could be caused increased mechanical tension, enhanced continuous gene mutation, as well cellular metabolic disorder, etc. Metabolic reprogramming is process pattern cells undergoes a systematic adjustment transformation adapt changes external environment meet needs their growth differentiation. Therefore, abnormality in within wounds scars attaches great importance scar formation. Mesenchymal stem cells-derived exosomes (MSC-Exo) are vesicles that play an important role tissue repair, cancer treatment immune regulation. However, there not work detail relevant studies. Herein, we gave comprehensive summary existing research on three main metabolisms, including glycometabolism, lipid metabolism amino acid metabolism, MSC-Exo regulating formation for further reference.
Язык: Английский
Процитировано
4
World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(3)
Опубликована: Фев. 13, 2025
In this article, we revisit an which specifically focuses on the utilization of exosomes derived from human bone marrow mesenchymal stem cells (MSCs) for targeted delivery gemcitabine in pancreatic cancer treatment. The experimental results demonstrated that exosome-based drug system MSCs significantly augmented apoptosis cells. biocompatibility, targeting specificity, and low immunogenicity render them as optimal carriers delivery, enabling precise administration therapeutics to diseased tissues while mitigating adverse effects, thereby achieving treatment enhancing anti-tumor efficacy. However, clinical application exosome platforms oncology still presents challenges, necessitating further optimization ensure their stability This study elucidating advantages a platform, exploring MSC-derived therapy, discussing potential future directions
Язык: Английский
Процитировано
0
Extracellular Vesicles and Circulating Nucleic Acids, Год журнала: 2025, Номер unknown, С. 54 - 71
Опубликована: Фев. 14, 2025
Triple-negative breast cancer (TNBC) is one of the most aggressive and challenging subtypes for treatment, due to lack hormone receptors human epidermal growth factor receptor 2 (HER2) protein. The identification new molecular targets important development targeted specific therapies TNBC patients. MicroRNAs (miRNAs) have emerged as promising targets, being involved in cellular processes such cell survival, apoptosis, differentiation, carcinogenesis, metastasis. Extracellular vesicles (EVs) gained prominence areas drug delivery, immune modulation, biomarkers diagnosis prognosis, therapeutics, their use vehicles delivery miRNAs, regulation gene expression, combined therapeutic strategies. In particular, mesenchymal stem cell-derived EVs (MSC-derived EVs) can transfer proteins, mRNAs/miRNAs, or DNA molecules are considered safer treatment options inability directly form tumors contain lower amounts membrane proteins MHC molecules. Numerous studies highlighted role miRNAs tumorigenesis, with a focus on diagnosis, selection, monitoring. However, EVs, especially MSC-derived still its infancy. Therefore, aim this review address strategies based through an innovative therapy oncology.
Язык: Английский
Процитировано
0
Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown
Опубликована: Апрель 3, 2025
Язык: Английский
Процитировано
0
Advanced Biology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Abstract Extracellular vesicles (EVs) are nanoscale luminal vesicles, which play an important role in intercellular communication through surface signaling and molecular cargo delivery (proteins, lipids, nucleic acids, etc.). Recently, plant‐derived extracellular (PDVs) containing multiple biological activities have received increasing attention due to their better biocompatibility lower cytotoxicity healthy tissues. In the biomedical field, PDVs employed as vehicles, enabling diverse functionalities engineering modification techniques. Nonetheless, there certain issues with study of PDVs, such lack standardization identification isolation criteria. This review provides a quick overview biogenesis, physicochemical properties, techniques, applications current studies, while critically analyzing challenges opportunities. paper is expected provide some theoretical guidance for development further applications.
Язык: Английский
Процитировано
0
Small Methods, Год журнала: 2025, Номер unknown
Опубликована: Апрель 8, 2025
Abstract Exosomes, small extracellular vesicles with lipid bilayer membranes, play a crucial role in cellular communication and can transfer diverse biological cargo, including proteins, lipids, nucleic acids, from donor to recipient cells. Exosomes possess immunological properties, such as antigen delivery immune activation, along excellent drug capabilities, making them promising candidates for vaccine development. For different diseases, exosome‐based vaccines be designed therapeutic or prophylactic by leveraging immunity humoral immunity. With the emergence of precision medicine, personalized demonstrate exceptional potential. This review systematically introduces sources, biogenesis mechanisms, components exosomes describes their regulatory roles system. Subsequently, preparation, administration, therapy are discussed. Finally, applications clinical trials fields anti‐infection anti‐tumor therapies particularly highlighted, an analysis potential challenges future
Язык: Английский
Процитировано
0