Nucleic acids based integrated macromolecular complexes for SiRNA delivery: Recent advancements DOI
Dilpreet Singh, Lovedeep Singh, Simranjeet Kaur

и другие.

Nucleosides Nucleotides & Nucleic Acids, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Май 1, 2024

The therapeutic potential of small interfering RNA (siRNA) is monumental, offering a pathway to silence disease-causing genes with precision. However, the delivery siRNA target cells

Язык: Английский

Applications of smart responsive nanomaterials in the theranostics of gastrointestinal malignancies: Current status and future perspectives DOI
Wenpeng Huang,

Jingwei Zhou,

Yutong Liang

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216641 - 216641

Опубликована: Март 30, 2025

Язык: Английский

Процитировано

0
Bimodal Poly(lactic-co-glycolic acid) Nanocarrier with Zinc Oxide and Iron Oxide for Fluorescence and Magnetic Resonance Imaging DOI Creative Commons
Thúlio Wliandon Lemos Barbosa, Laurent Lemaire,

Isabelle Verdu

и другие.

Molecules, Год журнала: 2025, Номер 30(8), С. 1818 - 1818

Опубликована: Апрель 18, 2025

Zinc oxide (ZnO) and iron (IO) nanoparticles have been identified as promising candidates for biomedical applications, based on their unique physicochemical properties. The association of these in a single system creates bimodal entity, allowing the excellent luminescent properties ZnO quantum dots to be combined with contrast agent IO magnetic resonance imaging (MRI). present study focuses MRI new poly(lactic-co-glycolic acid) (PLGA) nanocarrier formulation containing NPs different nominal ratios. Microscopic analysis (TEM SEM) reveals circular morphology NPs. average diameter particles was determined 220 nm, measured by DLS. luminescence results indicate that PLGA shows strong emission visible range, high r2 relaxivity 171 mM−1 s−1 at 7T. optimized formulation, exhibiting molar ratio Fe:Zn ranging from 1:10 1:13 (mol:mol), demonstrates superior fluorescence performance, underscoring significance nanoparticle composition applications. systems evaluated demonstrate no toxicity THP-1 cells doses up 128 µg mL−1, efficient labeling after 4 h incubation, yielding images T2 contrast. PLGA:ZnO:IO considerable potential platform diagnostic imaging.

Язык: Английский

Процитировано

0
Nucleic acids based integrated macromolecular complexes for SiRNA delivery: Recent advancements DOI
Dilpreet Singh, Lovedeep Singh, Simranjeet Kaur

и другие.

Nucleosides Nucleotides & Nucleic Acids, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Май 1, 2024

The therapeutic potential of small interfering RNA (siRNA) is monumental, offering a pathway to silence disease-causing genes with precision. However, the delivery siRNA target cells

Язык: Английский

Процитировано

0