Comparative analysis of PLGA ocuserts of brimonidine tartrate prepared with different methods DOI Creative Commons

Paramjot,

Sheetu Wadhwa,

Saurabh Singh

и другие.

European Pharmaceutical Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 17, 2025

Abstract The eye is a highly sensitive organ with multiple physiological barriers that limit drug bioavailability and reduce patient compliance. Research studies are still going on to discover novel delivery system for ocular delivery. current research aims develop compare the PLGA ocuserts of brimonidine tartrate (BT) by different methods. These BT-loaded offer promising alternative commercially available BT drops. Ocuserts could significantly minimize challenges encountered drops like lacrimation, blinking-induced washout, dosing frequency, penetration, stability, controlled release issues. were prepared using two methods: solvent casting method (SCM) glass substrate (GSM). Both SCM GSM formulations exhibited smooth texture, pH levels within range 6.88±0.24 6.90±0.28, uniform thickness (SCM: 0.47±0.10 mm; GSM: 0.29±0.03 mm), minimal weight variation 7.83±0.38 mg; 6.55±0.76 mg), sterility, appropriate swelling indices 6.69±0.33%; 5.40±0.27%). evaluation results revealed positive attributes ophthalmic use. Noteworthy distinctions emerged in folding endurance, demonstrating higher endurance (87.17±4.34 folds) than (71.33±4.82 folds). Moreover, superior entrapment efficiency (88.26±3.33 %) (74.91±4.39 %). Stability confirmed good stability over 6-month period, while vitro (italics) study indicated better properties GSM. Findings demonstrate as an effective preparation polymeric films various pharmaceutical industries, including transdermal patches, scaffolds tissue engineering, flexible wound healing films, biodegradable systems, packaging well.

Язык: Английский

Revolutionizing drying chambers for sustainable energy technologies in food and agriculture: A comprehensive review DOI
Muhammad Aqil Afham Rahmat, Adnan Ibrahim,

Muhammad Ubaidah Syafiq Mustaffa

и другие.

Sustainable Energy Technologies and Assessments, Год журнала: 2025, Номер 75, С. 104205 - 104205

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

10
Topical Ocular Drug Delivery: The Impact of Permeation Enhancers DOI Creative Commons
Gonçalo Santos, Esmeralda Delgado, Beatriz Silva

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 447 - 447

Опубликована: Март 31, 2025

Topical ophthalmic drug delivery targeting the posterior segment of eye has become a key area interest due to its non-invasive nature, safety, ease application, patient compliance, and cost-effectiveness. However, achievement effective bioavailability in ocular is significant challenge unique barriers, including precorneal factors anatomical like cornea, conjunctiva, sclera. Successful systems require increased residence time improved corneal penetration enhance intraocular bioavailability. A promising strategy overcome these barriers incorporating enhancers (DPEs) into formulations. These compounds facilitate by improving permeability across otherwise impermeable or poorly permeable membranes. At level, they act through three primary mechanisms: breaking tear film stability interfering with mucous layer; disrupting membrane components such as phospholipids proteins; loosening epithelial cellular junctions. DPEs offer potential improve therapeutic outcomes, particularly for drugs eye. This review focused on analyzing current literature regarding use topical delivery, highlighting their mechanisms action revolutionize treatments.

Язык: Английский

Процитировано

1
Comparative analysis of PLGA ocuserts of brimonidine tartrate prepared with different methods DOI Creative Commons

Paramjot,

Sheetu Wadhwa,

Saurabh Singh

и другие.

European Pharmaceutical Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 17, 2025

Abstract The eye is a highly sensitive organ with multiple physiological barriers that limit drug bioavailability and reduce patient compliance. Research studies are still going on to discover novel delivery system for ocular delivery. current research aims develop compare the PLGA ocuserts of brimonidine tartrate (BT) by different methods. These BT-loaded offer promising alternative commercially available BT drops. Ocuserts could significantly minimize challenges encountered drops like lacrimation, blinking-induced washout, dosing frequency, penetration, stability, controlled release issues. were prepared using two methods: solvent casting method (SCM) glass substrate (GSM). Both SCM GSM formulations exhibited smooth texture, pH levels within range 6.88±0.24 6.90±0.28, uniform thickness (SCM: 0.47±0.10 mm; GSM: 0.29±0.03 mm), minimal weight variation 7.83±0.38 mg; 6.55±0.76 mg), sterility, appropriate swelling indices 6.69±0.33%; 5.40±0.27%). evaluation results revealed positive attributes ophthalmic use. Noteworthy distinctions emerged in folding endurance, demonstrating higher endurance (87.17±4.34 folds) than (71.33±4.82 folds). Moreover, superior entrapment efficiency (88.26±3.33 %) (74.91±4.39 %). Stability confirmed good stability over 6-month period, while vitro (italics) study indicated better properties GSM. Findings demonstrate as an effective preparation polymeric films various pharmaceutical industries, including transdermal patches, scaffolds tissue engineering, flexible wound healing films, biodegradable systems, packaging well.

Язык: Английский

Процитировано

0