A Bioinspired Nanovaccine for Personalized Cancer Immunotherapy DOI
Lanqing Luo, Junyao Li, Xueying Shen

и другие.

Nano Letters, Год журнала: 2024, Номер 24(49), С. 15758 - 15766

Опубликована: Ноя. 25, 2024

Poly I:C (pIC) can act on endosomal and cytosolic pathogen recognition receptors to enhance T cell immunity. However, the poor delivery of pIC lack facile methods for codelivery with antigens limit its efficacy. Inspired by structure a virus, we developed

Язык: Английский

Polyethyleneimine/fucoidan polyplexes as vaccine carriers for enhanced antigen loading and dendritic cell activation DOI
Jen-Ron Chiang, Tzu‐Shun Lin, Junxiong Cheng

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141336 - 141336

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Advancements and challenges in personalized neoantigen-based cancer vaccines DOI Creative Commons

Parminder Singh,

Mahalaqua Nazli Khatib,

R Roopashree

и другие.

Oncology Reviews, Год журнала: 2025, Номер 19

Опубликована: Март 14, 2025

Advancements in personalized neoantigen-based cancer vaccines are ushering a new era oncology, targeting unique genetic alterations within tumors to enhance treatment precision and efficacy. Neoantigens, specific cells absent normal tissues, at the heart of these vaccines, promising direct immune system specifically against tumor, thereby maximizing therapeutic efficacy while minimizing side effects. The identification neoantigens through genomic proteomic technologies is central developing allowing for precise mapping tumor's mutational landscape. Despite advancements, accurately predicting which will elicit strong responses remains challenging due tumor variability complexity interactions. This necessitates further refinement bioinformatics tools predictive models. Moreover, heavily depends on innovative delivery methods that neoantigen presentation system. Techniques like encapsulating lipid nanoparticles using viral vectors critical improving vaccine stability delivery. Additionally, contribute towards achieving Sustainable Development Goal 3.8, promoting universal health coverage by advancing access safe effective treatments. review delves into potential transform treatment, examining both revolutionary advancements ongoing challenges they face.

Язык: Английский

Процитировано

0
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy DOI Creative Commons

Jordi Madariaga Burgos,

E. Vega,

María L. García

и другие.

Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(9), С. 1385 - 1394

Опубликована: Сен. 1, 2024

In recent years, chimeric antigen receptor T (CAR-T) cell therapy has resulted in a breakthrough the treatment of patients with refractory or relapsed hematological malignancies. However, identification suitable for CAR-T needs to be improved.

Язык: Английский

Процитировано

0
A Bioinspired Nanovaccine for Personalized Cancer Immunotherapy DOI
Lanqing Luo, Junyao Li, Xueying Shen

и другие.

Nano Letters, Год журнала: 2024, Номер 24(49), С. 15758 - 15766

Опубликована: Ноя. 25, 2024

Poly I:C (pIC) can act on endosomal and cytosolic pathogen recognition receptors to enhance T cell immunity. However, the poor delivery of pIC lack facile methods for codelivery with antigens limit its efficacy. Inspired by structure a virus, we developed

Язык: Английский

Процитировано

0