Hyaluronic acid-based hesperidin nanostructured lipid carriers loaded dissolving microneedles: A localized delivery approach loaded for the management of obesity
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140948 - 140948
Опубликована: Фев. 1, 2025
Язык: Английский
Phytochemicals Modulate Biosynthesis and Function of Serotonin, Dopamine, and Norepinephrine for Treatment of Monoamine Neurotransmission-Related Psychiatric Diseases
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2916 - 2916
Опубликована: Март 23, 2025
Serotonin
(5-HT),
dopamine
(DA),
and
norepinephrine
(NE)
are
key
monoamine
neurotransmitters
regulating
behaviors,
mood,
cognition.
5-HT
affects
early
brain
development,
its
dysfunction
induces
vulnerability
to
stress,
raising
the
risk
of
depression,
anxiety,
autism
in
adulthood.
These
synthesized
from
tryptophan
tyrosine
via
hydroxylation
decarboxylation,
metabolized
by
oxidase
(MAO).
This
review
aims
summarize
current
findings
on
role
dietary
phytochemicals
modulating
neurotransmitter
biosynthesis,
metabolism,
function,
with
an
emphasis
their
potential
therapeutic
applications
neuropsychiatric
disorders.
Phytochemicals
exert
antioxidant,
neurotrophic,
neurohormonal
activities,
regulate
gene
expression,
induce
epigenetic
modifications.
Phytoestrogens
activate
estrogen
receptors
or
estrogen-responsive
elements
promoter
target
genes,
enhance
transcription
hydroxylase
hydroxylase,
while
inhibiting
that
MAO.
compounds
also
influence
interaction
between
genetic
environmental
factors,
potentially
reversing
dysregulated
neurotransmission
architecture
associated
conditions.
Despite
promising
preclinical
findings,
clinical
remain
challenging.
Advances
nanotechnology
targeted
delivery
systems
offer
solutions
efficacy.
discusses
mechanisms,
challenges,
strategies,
underscoring
need
for
further
research
advance
phytochemical-based
interventions
diseases.
Язык: Английский
Stearyl amine coated liposome of rotigotine alleviates cognitive deficit in Parkinson’s disease induced mice model: modulation of oxidative stress, and motor coordination
Drug Development and Industrial Pharmacy,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Апрель 16, 2025
The
study
was
conducted
to
evaluate
the
brain
targeted
delivery
of
cationic
liposomes
rotigotine
via
nasal
route,
addressing
limitations
in
penetration
for
Parkinson's
disease
intervention.
Cationic
were
fabricated
and
optimized
using
a
Box-Behnken
design
improve
excipient
composition
effective
intranasal
delivery.
liposome,
LR12,
surface
modified
with
stearylamine
at
three
concentrations
confer
charge.
final
formulation,
RTG-LP3,
evaluated
physicochemical
parameters,
including
size,
entrapment
efficiency,
zeta
potential.
A
morphological
performed
within
100-200
nm
size
range.
cytotoxicity
RTG-LP3
determined
SH-SY5Y
cell
lines,
whereas
pharmacodynamic
studies
C57BL/6
mice
following
administration.
formulation
exhibited
minimal
vesicle
162
±
2.94
nm,
high
efficiency
86.53
0.33%,
positive
potential
+19.8
2.45
mV.
Morphological
investigation
indicated
spherical
shape
range
nm.
Cytotoxicity
showed
fivefold
safety
margin
when
compared
rotigotine.
Pharmacodynamic
assessments
PD-induced
C57BL6
increased
motor
coordination
antioxidant
benefits
treatment.
Histological
regions
treated
demonstrated
improved
neuronal
architecture,
indicating
reduced
neurodegeneration
condition.
liposome
superior
therapeutic
effects
treating
PD
route.
These
findings
highlight
as
viable
method
improving
neuroprotection
therapy.
Язык: Английский
Microneedle system for tissue engineering and regenerative medicines: a smart and efficient therapeutic approach
Biofabrication,
Год журнала:
2024,
Номер
16(4), С. 042005 - 042005
Опубликована: Авг. 9, 2024
The
global
demand
for
an
enhanced
quality
of
life
and
extended
lifespan
has
driven
significant
advancements
in
tissue
engineering
regenerative
medicine.
These
fields
utilize
a
range
interdisciplinary
theories
techniques
to
repair
structurally
impaired
or
damaged
tissues
organs,
as
well
restore
their
normal
functions.
Nevertheless,
the
clinical
efficacy
medications,
materials,
potent
cells
used
at
laboratory
level
is
always
constrained
by
technological
limitations.
A
novel
platform
known
adaptable
microneedles
been
developed
address
abovementioned
issues.
offer
solution
localized
distribution
various
cargos
while
minimizing
invasiveness.
Microneedles
provide
favorable
patient
compliance
settings
due
effective
administration
ability
painless
convenient
process.
In
this
review
article,
we
summarized
most
recent
development
microneedles,
started
classifying
microneedle
systems,
advantages,
fundamental
properties.
Subsequently,
it
provides
comprehensive
overview
different
types
material
fabricate
properties
ideal
applications
medicine,
primarily
focusing
on
preserving
restoring
organs.
limitations
perspectives
have
discussed
concluding
future
therapeutic
medicines.
Язык: Английский
Advancing lipid nanoparticles: A pioneering technology in cosmetic and dermatological treatments
Colloids and Interface Science Communications,
Год журнала:
2024,
Номер
64, С. 100814 - 100814
Опубликована: Дек. 7, 2024
Язык: Английский
Wine, Polyphenols and the Matrix Effect: Is Alcohol Always the Same?
Опубликована: Июль 16, 2024
While
the
number
of
publications
on
wine
and
health
is
steadily
increasing,
ranging
from
molecular
level
to
epidemiological
studies,
often
with
contradictory
results,
little
attention
has
been
given
an
holistic
approach.
In
this
review
some
unusual
concepts
are
considered,
such
as
phytocomplex,
vehicle
Matrix
effect.
As
example,
three
mono/polyphenols
present
in
wine,
Tyrosol,
Hydroxytyrosol
Resveratrol,
have
selected
consequences
respecting,
disregarding
or
ignoring
effect
shown.
Underestimation
could
lead
deceiving
case
de-alcoholized
wine-compound-based
nutritional
supplements,or
emphasizing
a
single
component
toxic
activity,
alcohol,
specific
protective
action
at
other
compounds
(polyphenols)
same
Matrix.
The
dark
side
also
discussed.
It
suggested
that
specificity
should
be
always
taken
consideration
by
public
Authorities.
Язык: Английский
Wine, Polyphenols, and the Matrix Effect: Is Alcohol Always the Same?
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9796 - 9796
Опубликована: Сен. 10, 2024
While
the
number
of
publications
on
wine
and
health
is
steadily
increasing,
ranging
from
a
molecular
level
to
epidemiological
studies,
often
with
contradictory
results,
little
attention
has
been
given
holistic
approach
research,
starting
arrive
at
pharmacological
medical
conclusions.
In
this
review,
some
unusual
concepts
are
considered,
such
as
phytocomplex,
vehicle,
Matrix
effect.
The
concept
phytocomplex
discussed,
specifically
biological
activities
Tyrosol,
Hydroxytyrosol,
Resveratrol;
indeed,
interactions
among
different
molecules
in
herbal
matrices
provide
specific
response.
This
markedly
response
evoked
by
single
constituents
modulation
microbial
populations
gut,
intestinal
stability
bioaccessibility,
and,
obviously,
inducing
responses.
Among
many
alcoholic
beverages
which
contain
these
molecules,
most
peculiar
effect,
can
heavily
influence
bioavailability
obtained
fermentation
processes
that
produce
beverage.
Wine's
effect
plays
an
instrumental
role
improving
beneficial
compounds'
and/or
inhibiting
alcohol
metabolites'
carcinogenicity.
Underestimation
could
lead
deceiving
case
dealcoholized
or
wine-compound-based
nutritional
supplements;
alternatively,
occur
emphasis
component's
toxic
activity,
case,
alcohol,
ignoring
molecular-level
protective
action
other
compounds
(polyphenols)
present
same
matrix.
dark
side
also
discussed.
review
confirms
research
recommendations
made
WHO
Scientific
Group,
suggests
it
important
"to
investigate
possible
effects
ingredients
than
beverages",
considering
recent
studies
seem
not
only
relevant
but
capable
directing
future
towards
innovative
points
view
have
so
far
too
neglected.
Язык: Английский
ANTI-OBESITY EFFECT OF RESVERATROL-LOADED DISSOLVING MICRONEEDLE PATCH: IN VITRO AND IN VIVO STUDIES
Materials Today Communications,
Год журнала:
2024,
Номер
unknown, С. 111011 - 111011
Опубликована: Ноя. 1, 2024
Язык: Английский
Phytomedicine Nanoformulations for Parkinson's disease
Phytomedicine Plus,
Год журнала:
2024,
Номер
5(1), С. 100704 - 100704
Опубликована: Дек. 12, 2024
Язык: Английский
A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Nanomaterial‐loaded
microneedles
are
a
novel
development
in
the
fields
of
medicine
and
vaccines.
Researchers
have
created
extremely
effective
systems
for
targeted
controlled
delivery
variety
bioactive
agents
by
fusing
nanomaterials
with
microneedle
platforms.
The
design
manufacturing
processes
nanomaterial‐loaded
covered
herein,
along
applications
to
improve
drug
stability,
bioavailability,
patient
adherence.
Important
preclinical
clinical
studies
that
demonstrate
efficiency
these
delivering
small
molecules,
biologics,
vaccines
also
review.
In
order
direct
ongoing
research
expedite
translation
this
promising
technology,
important
challenges
future
directions
identified.
This
review
offers
thorough
evaluation
most
recent
developments
quickly
developing
field
technology.
Язык: Английский