Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gut microbiota
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 7, 2025
Despite
the
approval
of
several
artificial
nanotherapeutics
for
treatment
triple-negative
breast
cancer
(TNBC),
significant
challenges,
including
unsatisfactory
therapeutic
outcomes,
severe
side
effects,
and
high
cost
large-scale
production,
still
restrict
their
long-term
application.
In
contrast,
plant-derived
extracellular
vesicles
(PEVs)
exhibit
promising
potential
in
therapy
due
to
negligible
systemic
toxicity,
bioavailability
cost-
effectiveness.
this
study,
we
developed
an
alternative
strategy
inhibit
TNBC
via
Platycodon
grandiflorum
(PG)-derived
(PGEVs).
The
PGEVs
were
isolated
by
ultracentrifugation
sucrose
gradient
centrifugation
method
contained
adequate
functional
components
such
as
proteins,
lipids,
RNAs
active
molecules.
exhibited
remarkable
stability,
tolerating
acidic
digestion
undergoing
minimal
changes
simulated
gastrointestinal
fluid.
They
efficiently
taken
up
tumor
cells
induced
increased
production
reactive
oxygen
species
(ROS),
leading
cell
proliferation
inhibition
apoptosis,
particularly
line
4T1.
Additionally,
facilitated
polarization
tumor-associated
macrophages
(TAMs)
toward
M1
phenotype
secretion
pro-inflammatory
cytokines.
Further
vivo
investigations
revealed
that
accumulated
4T1
tumors
exerted
effects
through
boosting
anti-tumor
immune
responses
modulating
gut
microbiota
whether
administered
orally
or
intravenously
(i.v.).
conclusion,
these
findings
highlight
a
natural,
biocompatible
efficient
nanotherapeutic
candidate
treating
TNBC.
Язык: Английский
The role of quercetin in NLRP3-associated inflammation
Inflammopharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 22, 2024
Язык: Английский
Evolution and Impact of Imine Reductases (IREDs) Research: A Knowledge Mapping Approach
Molecular Biotechnology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Язык: Английский
Nanotechnology in prostate cancer: a bibliometric analysis from 2004 to 2023
Discover Oncology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 2, 2025
Prostate
cancer
(PC)
contributes
to
male
mortality
worldwide.
The
objective
of
this
study
is
comprehensively
depict
the
scientific
accomplishments
and
research
trends
in
nanotechnology
for
PC
applications.
Utilizing
Web
Science
Core
Collection
database,
publications
were
gathered
on
basis
inclusion
selection
criteria.
analyzed
visualized
using
VOSviewer,
R-studio
CiteSpace
software
tools.
A
total
1949
studies
incorporated.
Farokhzad
was
most
productive
author.
United
States
China
released
58.13%
publications.
Chinese
Academy
Sciences
influential
institution,
International
Journal
Nanomedicine
stood
out
as
a
prominent
journal
field.
frequently
referenced
publication
subject
category
identified.
extensively
investigated
area
nanoparticle-based
drug
delivery,
while
recent
has
focused
anticancer
with
novel
nanocarriers.
bibliometric
analysis
conducted
between
2004
2023.
overview
characteristics
We
discussed
application
restrictions
faced
by
management.
treatment
needs
be
further
studied.
Язык: Английский