Immune Modulation with Oral DNA/RNA Nanoparticles
Pharmaceutics,
Год журнала:
2025,
Номер
17(5), С. 609 - 609
Опубликована: Май 4, 2025
The
oral
delivery
of
DNA/RNA
nanoparticles
represents
a
transformative
approach
in
immunotherapy
and
vaccine
development.
These
enable
targeted
immune
modulation
by
delivering
genetic
material
to
specific
cells
the
gut-associated
system,
triggering
both
mucosal
systemic
responses.
Unlike
parenteral
administration,
route
offers
unique
immunological
environment
that
supports
tolerance
activation,
depending
on
formulation
design.
This
review
explores
underlying
mechanisms
nanoparticles,
their
design
strategies,
recent
advances
application.
Emphasis
is
placed
strategies
overcome
physiological
barriers
such
as
acidic
pH,
enzymatic
degradation,
mucus
entrapment,
epithelial
tight
junctions.
Special
attention
given
role
lymphoid
tissue
mediating
responses
therapeutic
potential
these
systems
platforms,
food
allergies,
autoimmune
diseases,
chronic
inflammation.
Despite
challenges,
nanoparticle
support
translation
technologies
into
clinical
applications
for
immunomodulation
vaccination.
Язык: Английский
A Multimodal Therapeutic Strategy for Inflammatory Bowel Disease Using MicroRNA-146a Mimic Encapsulated in Lipid Nanoparticles
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
Dysregulated
microRNAs
(miRNAs)
have
significant
potential
as
diagnostic
tools
for
various
chronic
diseases;
however,
their
therapeutic
applications
remain
largely
unexplored.
Given
capacity
to
regulate
multiple
pathways,
miRNAs
are
promising
candidates
treating
pleiotropic
diseases,
such
inflammatory
bowel
disease
(IBD).
In
our
study,
we
conducted
a
comprehensive
review
of
the
literature
miRNA-146
levels
in
inflamed
tissues
IBD
patients
and
murine
colitis
models.
Initially,
quantified
expression
miRNA-146a
miRNA-146b
colons
mice
using
dextran
sodium
sulfate
(DSS)-inducedacute
model
IBD.
We
selected
further
study
due
its
anti-inflammatory
properties
relevance
treatment.
hypothesized
that
macrophage
inflammation
would
be
well-suited
studying
effects
this
miRNA.
Subsequently,
investigated
use
lipid
nanoparticles
(LNPs)
targeted
delivery
macrophages,
which
play
key
role
Our
results
indicated
increased
DSS
LNP-mediated
effectively
downregulated
genes
associated
with
inflammation.
These
findings
highlight
critical
modulating
suggest
LNP-based
could
strategy
managing
responses.
Язык: Английский
Versatility of LNPs across different administration routes for targeted RNA delivery
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
advent
of
lipid
nanoparticle
(LNP)
technology
has
marked
a
significant
breakthrough
in
the
field
drug
delivery,
offering
unprecedented
opportunities
gene
therapy,
vaccine
and
personalized
medicine.
Язык: Английский
New insights for the development of efficient DNA vaccines
Microbial Biotechnology,
Год журнала:
2024,
Номер
17(11)
Опубликована: Ноя. 1, 2024
Abstract
Despite
the
great
potential
of
DNA
vaccines
for
a
broad
range
applications,
ranging
from
prevention
infections,
over
treatment
autoimmune
and
allergic
diseases
to
cancer
immunotherapies,
implementation
such
therapies
clinical
is
far
behind
expectations
up
now.
The
main
reason
poor
immunogenicity
in
humans.
Consequently,
improvement
performance
vivo
required.
This
mini‐review
provides
an
overview
current
state
various
strategies
enhance
immunogenic
vaccines,
including
(i)
optimization
construct
itself
regarding
size,
nuclear
transfer
transcriptional
regulation;
(ii)
use
appropriate
adjuvants;
(iii)
improved
delivery,
example,
by
careful
choice
administration
route,
physical
methods
as
electroporation
nanomaterials
that
may
allow
cell
type‐specific
targeting.
Moreover,
combining
nanoformulated
with
other
immunotherapies
prime‐boost
help
success
treatment.
Язык: Английский