Emerging role of exosomes in cancer therapy: progress and challenges
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Язык: Английский
MicroRNAs in Parkinson’s disease: From pathogenesis to diagnostics and therapeutic strategies
Dongying Zheng,
Jibing Chween
Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Therapeutic Targets in Glioblastoma: Molecular Pathways, Emerging Strategies, and Future Directions
Cells,
Год журнала:
2025,
Номер
14(7), С. 494 - 494
Опубликована: Март 26, 2025
Glioblastoma
(GBM)
is
the
most
aggressive
primary
brain
tumor
in
adults,
characterized
by
rapid
growth,
invasive
infiltration
into
surrounding
tissue,
and
resistance
to
conventional
therapies.
Despite
advancements
surgery,
radiotherapy,
chemotherapy,
median
survival
remains
approximately
15
months,
underscoring
urgent
need
for
innovative
treatments.
Key
considerations
informing
treatment
development
include
oncogenic
genetic
epigenetic
alterations
that
may
dually
serve
as
therapeutic
targets
facilitate
resistance.
Various
immunotherapeutic
strategies
have
been
explored
continue
be
refined
their
anti-tumor
potential.
Technical
aspects
of
drug
delivery
blood–brain
barrier
(BBB)
penetration
addressed
through
novel
vehicles
techniques
including
incorporation
nanotechnology.
Molecular
profiling
has
emerged
an
important
tool
individualize
where
applicable,
identify
patient
populations
with
sensitivity.
The
goal
this
review
describe
spectrum
potential
GBM
targets,
provide
overview
key
trial
outcomes.
Altogether,
progress
clinical
preclinical
work
must
critically
evaluated
order
develop
therapies
strongest
efficacy.
Язык: Английский
Unveiling exosomal biomarkers in neurodegenerative diseases: LC-MS-based profiling
Extracellular Vesicle,
Год журнала:
2025,
Номер
5, С. 100071 - 100071
Опубликована: Март 22, 2025
Язык: Английский
Cancer mRNA vaccines: clinical application progress and challenges
Hang Li,
Lequan Min,
Haotian Du
и другие.
Cancer Letters,
Год журнала:
2025,
Номер
625, С. 217752 - 217752
Опубликована: Апрель 28, 2025
Язык: Английский
Exosomes in Dermatology: Emerging Roles in Skin Health and Disease
Pharmaceutics,
Год журнала:
2025,
Номер
17(5), С. 600 - 600
Опубликована: Май 2, 2025
Background/Objectives:
Exosomes,
nanosized
vesicles
secreted
by
diverse
cell
types,
have
emerged
as
critical
mediators
of
intercellular
communication,
tissue
repair,
and
disease
pathogenesis.
Their
roles
in
dermatology
are
increasingly
recognized,
influencing
skin
health
the
progression
various
dermatological
conditions.
This
review
aims
to
explore
biogenesis,
composition,
mechanisms
exosome
uptake
cells
their
implications
research
clinical
practice.
Methods:
A
comprehensive
existing
literature
was
conducted
elucidate
biological
composition
exosomes,
homeostasis,
involvement
processes,
such
wound
healing,
regeneration,
barrier
function
maintenance.
also
examined
diagnostic
therapeutic
potential
exosomes
conditions
psoriasis,
eczema,
acne,
cancer.
Results:
Exosomes
were
found
contain
intricate
compositions,
including
proteins,
lipids,
nucleic
acids,
bioactive
molecules,
crucial
for
maintaining
homeostasis.
They
demonstrated
significant
modulating
healing
regeneration.
Emerging
evidence
highlights
biomarkers
agents.
Exosome-based
approaches
hold
promise
advancing
management,
although
challenges
remain
translating
these
findings
into
applications.
Conclusions:
represent
a
promising
frontier
dermatology,
with
revolutionize
understanding,
diagnosis,
treatment
skin-related
disorders.
Despite
challenges,
complexity
versatility
underscore
developing
personalized
strategies.
Further
is
warranted
address
gaps
harness
full
Язык: Английский
Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Май 3, 2025
The
blood-brain
barrier
(BBB)
presents
a
formidable
challenge
in
neuropharmacology,
limiting
the
delivery
of
therapeutic
agents
to
brain.
Exosomes,
nature's
nanocarriers,
have
emerged
as
promising
solution
due
their
biocompatibility,
low
immunogenicity,
and
innate
ability
traverse
BBB.
A
thorough
examination
BBB
anatomy
physiology
reveals
complexities
neurological
drug
underscores
limitations
conventional
methods.
This
review
explores
potential
exosome-powered
neuropharmaceutics,
highlighting
structural
functional
properties,
biogenesis,
mechanisms
release.
Their
intrinsic
advantages
delivery,
including
enhanced
stability
efficient
cellular
uptake,
are
discussed
detail.
Exosomes
naturally
overcome
barriers
through
specific
translocation
mechanisms,
making
them
compelling
vehicle
for
targeted
brain
therapies.
Advances
engineering
strategies,
such
genetic
biochemical
modifications,
loading
techniques,
specificity
enhancement,
further
bolster
potential.
Exosome-based
approaches
hold
immense
promise
treating
spectrum
disorders,
Alzheimer's,
Parkinson's,
amyotrophic
lateral
sclerosis
(ALS),
multiple
(MS),
tumors,
stroke,
psychiatric
conditions.
By
leveraging
properties
innovations,
exosomes
offer
versatile
platform
precision
neurotherapeutics.
Despite
promise,
challenges
remain
clinical
translation,
large-scale
production,
standardization,
regulatory
considerations.
Future
research
directions
exosome
nanobiotechnology
aim
refine
these
unlocking
new
avenues
diseases.
transformative
impact
exosome-based
paving
way
next-generation
therapies
that
can
effectively
penetrate
revolutionize
neuropharmacology.
Язык: Английский
Bacterial Extracellular Vesicles: Bridging Pathogen Biology and Therapeutic Innovation
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
The
main
role
of
bacterial
extracellular
vesicles
(BEVs)
has
been
associated
with
various
processes
such
as
intercellular
communication
and
host-pathogen
interactions.
This
comprehensive
review
explores
the
multifaceted
functions
BEVs
across
different
biological
domains,
emphasizing
their
contributors
both
to
disease
carriers
therapeutic
possibilities.
We
examine
intricate
interactions
within
communities
between
bacteria
hosts,
involvement
in
development
through
cargo
delivery
mechanisms,
beneficial
impact
microbial
ecology.
places
a
strong
emphasis
on
BEVs'
applications
biomedical
sciences,
where
they
are
revolutionizing
vaccine
development,
targeted
drug
delivery,
cancer
therapy.
By
utilizing
inherent
properties
for
controlled
release,
antigen
immune
modulation,
offer
promising
frontier
precision
medicine.
In
addition,
diagnostic
potential
is
explored
biomarker
capabilities,
providing
valuable
insights
into
states
treatment
efficacy.
Looking
forward,
this
underscores
challenges
opportunities
translating
BEV
research
clinical
practice,
promoting
use
standardized
methods
characterization
scaling
up
production.
diverse
abilities
BEVs,
ranging
from
contributing
pathogen
virulence
driving
innovation,
highlight
cornerstone
future
advancements.
STATEMENT
OF
SIGNIFICANCE:
Bacterial
emerging
pivotal
players
pathogenesis
innovation.
dual
nature
agents
biomaterials
applications,
provides
survey
mechanisms
ecology,
therapy
diagnosis.
It
highlights
complex
hosts.
also
addresses
current
advancements,
challenges,
practice.
presented
here
position
advocating
scalable
production
techniques.
Язык: Английский
Vesicles: New Advances in the Treatment of Neurodegenerative Diseases
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12672 - 12672
Опубликована: Ноя. 26, 2024
Neurodegenerative
diseases
are
characterized
by
brain
lesions
that
limit
normal
daily
activities
and
represent
a
major
challenge
to
healthcare
systems
worldwide,
with
significant
economic
impact.
Nanotechnology
is
the
science
of
manipulating
matter
at
nanoscale,
where
materials
exhibit
unique
properties
significantly
different
from
their
larger
counterparts.
These
can
be
exploited
for
wide
range
applications,
including
medicine.
Among
emerging
therapeutic
approaches
treatment
neurodegenerative
diseases,
nanotechnologies
gaining
prominence
as
promising
avenue
explore.
Here,
we
review
state
art
biological
artificial
vesicles
in
context
diseases.
Indeed,
nanometric
structures
such
extracellular
tool
disorders
due
size,
biocompatibility,
ability
transport
drugs,
proteins,
genetic
material
across
blood-brain
barrier
target
specific
cells
areas.
In
future,
deeper
broader
synergy
between
science,
bioengineering,
biology,
medicine,
discovery
new,
increasingly
powerful
delivery
will
certainly
enable
more
applied
use
nanotechnology
disorders.
Язык: Английский