Targeted Drug Delivery to the Spleen and Its Implications for the Prevention and Treatment of Cancer DOI Creative Commons
Ikramy A. Khalil, Ahmed Faheem, Mohamed El‐Tanani

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 651 - 651

Опубликована: Май 15, 2025

The spleen, the largest secondary lymphoid organ, plays several vital roles in body, including blood filtration, hematopoiesis, and immune regulation. Despite its importance, spleen has not received substantial attention as a target organ for drug delivery. Most systemically administered colloidal particulate carriers are cleared from by liver making these two organs potential targets accumulation. While various systems have been developed to liver, there is an urgent need design spleen-targeted delivery that can evade clearance degradation while delivering drugs efficiently their cells spleen. Targeting holds great treatment of range diseases, disorders, inflammatory infectious cancer. It also crucial development effective vaccines. In this review, we explore different approaches used after systemic administration, discuss factors shift biodistribution We focus on cell-specific within strategies avoid degradation, methods achieve efficient intracellular genes. highlight therapeutic implications systems, particularly prevention

Язык: Английский

Targeted Drug Delivery to the Spleen and Its Implications for the Prevention and Treatment of Cancer DOI Creative Commons
Ikramy A. Khalil, Ahmed Faheem, Mohamed El‐Tanani

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(5), С. 651 - 651

Опубликована: Май 15, 2025

The spleen, the largest secondary lymphoid organ, plays several vital roles in body, including blood filtration, hematopoiesis, and immune regulation. Despite its importance, spleen has not received substantial attention as a target organ for drug delivery. Most systemically administered colloidal particulate carriers are cleared from by liver making these two organs potential targets accumulation. While various systems have been developed to liver, there is an urgent need design spleen-targeted delivery that can evade clearance degradation while delivering drugs efficiently their cells spleen. Targeting holds great treatment of range diseases, disorders, inflammatory infectious cancer. It also crucial development effective vaccines. In this review, we explore different approaches used after systemic administration, discuss factors shift biodistribution We focus on cell-specific within strategies avoid degradation, methods achieve efficient intracellular genes. highlight therapeutic implications systems, particularly prevention

Язык: Английский

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