Development of κ-Carrageenan Films Reinforced with Magnesium Oxide Nanoparticles for the Potential Treatment of Chronic Wounds: In Vitro and In Vivo Insights

Polysaccharides, Год журнала: 2025, Номер 6(2), С. 45 - 45

Опубликована: Май 30, 2025

In this work, κ-carrageenan (κ-C) and polyethylene oxide (PEO) were utilized to synthesize polymeric films (κ-C-PEO). A 2k experimental design was employed optimize the synthesis of κ-C-PEO systems by considering content κ-carrageenan, PEO, glycerin their influence on mechanical features resultant films. The robustly characterized FTIR spectroscopy, thermogravimetric analyses, scanning electron microscopy (SEM). Magnesium nanoparticles (MgO-NPs) load as an efficient approach enhance biological performance. activity studied against Gram-negative bacteria through Kirby–Bauer assay. Artemia salina nauplii cultured assess possible toxicity results demonstrated that elongated with heterogeneous distribution MgO-NPs. tensile strength, thickness, swelling capacity 129 kPa, 0.19 mm, 52.01%, respectively. TGA DTA analyses revealed are thermally stable structures presenting significant mass loss patterns at >200 °C. Treatment did not inhibit growth Escherichia coli nor Pseudomonas aeruginosa. Against A. nauplii, decrease survival rate compromise morphology tested in vivo model. retrieved data from study expand knowledge about integrating inorganic nanomaterials polysaccharide-based application treating chronic wounds. Even though work provides innovative insights into optimal bioactive structures, further approaches required improve performance synthesized

Язык: Английский

Synergistic effects of nanoparticle addition and hydrogen enrichment fuels on CRDI engine: AI-based prediction of engine characteristics

Multiscale and Multidisciplinary Modeling Experiments and Design, Год журнала: 2024, Номер 8(7)

Опубликована: Июль 1, 2024

Язык: Английский