ACS Omega,
Год журнала:
2025,
Номер
10(13), С. 13645 - 13654
Опубликована: Март 27, 2025
This
is
the
report
of
HPLC-MSn-guided
isolation
new
anti-inflammatory
prenylated
isoflavonoids
and
pterocarpans
from
stems
Acosmium
diffusissimum
using
GNPS
molecular
networking
as
main
tool.
Cluster
analysis
guided
five
isoflavonoids,
diffusiflavone
A-E
(1-4
9),
two
pterocarpans,
diffusicarpan
A
B
(5
6),
known
compounds
6-prenylorobol
(7)
3-O-methylquercetin
(8).
The
in
vitro
potential
1-6
9
was
assessed
macrophages
induced
with
lipopolysaccharide
(LPS).
Compounds
2,
3,
5,
were
observed
to
have
a
reduction
NO
levels
at
least
one
concentrations
tested
(1.25,
2.5,
10,
20
μg/mL)
also
reduced
IL-1β
IL-6
cytokines,
especially
which
cytokine
all
tested.
Cancers,
Год журнала:
2025,
Номер
17(5), С. 723 - 723
Опубликована: Фев. 20, 2025
Background/Objectives:
Tumour-associated
macrophages
(TAMs)
are
critical
components
of
the
tumour
microenvironment
(TME),
significantly
influencing
cancer
progression
and
treatment
resistance.
This
review
aims
to
explore
innovative
use
engineered
bacteria
reprogram
TAMs,
enhancing
their
anti-tumour
functions
improving
therapeutic
outcomes.
Methods:
We
conducted
a
systematic
following
predefined
protocol.
Multiple
databases
were
searched
identify
relevant
studies
on
phenotypic
plasticity,
for
reprogramming.
Inclusion
exclusion
criteria
applied
select
studies,
data
extracted
using
standardised
forms.
Data
synthesis
was
performed
summarise
findings,
focusing
mechanisms
benefits
non-pathogenic
modify
TAMs.
Results:
The
summarises
findings
that
can
selectively
target
promoting
shift
from
tumour-promoting
M2
phenotype
tumour-fighting
M1
phenotype.
reprogramming
enhances
pro-inflammatory
responses
activity
within
TME.
Evidence
various
indicates
significant
regression
improved
immune
bacterial
therapy.
Conclusions:
Reprogramming
TAMs
presents
promising
strategy
approach
leverages
natural
targeting
abilities
directly
tumour,
potentially
patient
outcomes
offering
new
insights
into
immune-based
treatments.
Further
research
is
needed
optimise
these
methods
assess
clinical
applicability.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 385 - 411
Опубликована: Янв. 1, 2023
Abstract:
Wound
healing
is
a
complex
and
dynamic
process,
metabolic
disturbances
in
the
microenvironment
of
chronic
wounds
severe
symptoms
they
cause
remain
major
challenges
to
be
addressed.
The
inherent
properties
hydrogels
make
them
promising
wound
dressings.
In
addition,
biomembrane-based
nanostructures
microstructures
(such
as
liposomes,
exosomes,
membrane-coated
nanostructures,
bacteria
algae)
have
significant
advantages
promotion
healing,
including
special
biological
activities,
flexible
drug
loading
targeting.
Therefore,
nanostructure-
microstructure-loaded
can
compensate
for
their
respective
disadvantages
combine
both
significantly
promote
healing.
this
review,
we
outline
strategies,
mechanisms
action
applications
different
types
Keywords:
biomembrane,
microstructures,
hydrogels,
Journal of Cellular and Molecular Medicine,
Год журнала:
2023,
Номер
27(3), С. 311 - 321
Опубликована: Янв. 10, 2023
Abstract
Low
frequency
of
durable
responses
in
patients
treated
with
immune
checkpoint
inhibitors
(ICIs)
demands
for
taking
complementary
strategies
order
to
boost
against
cancer.
Transforming
growth
factor‐β
(TGF‐β)
is
a
multi‐tasking
cytokine
that
frequently
expressed
tumours
and
acts
as
critical
promoter
tumour
hallmarks.
TGF‐β
promotes
an
immunosuppressive
microenvironment
(TME)
defines
bypass
mechanism
the
ICI
therapy.
A
number
cells
within
stroma
are
influenced
from
activity.
There
also
evidence
relation
between
programmed
death‐ligand
1
(PD‐L1)
expression
TME,
it
influences
efficacy
anti‐programmed
death‐1
receptor
(PD‐1)
or
anti‐PD‐L1
Combination
anti‐PD(L)1
has
come
promising
outcomes,
clinical
trials
under
way
use
agents
bifunctional
capacity
fusion
proteins
bonding
traps
antibodies
aiming
at
reinvigorating
promoting
persistent
advanced
stage
cancers,
especially
immunologically
cold
ecosystem.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
15(1), С. 52 - 96
Опубликована: Сен. 14, 2024
Modern
oncology
is
rapidly
evolving,
driven
by
recent
advances
in
RNA-based
therapeutics.
As
new
emerging
cutting-edge
technology,
mRNA
vaccines
hold
excellent
promise
for
encoding
immunostimulatory
molecules,
tumor-associated
antigens,
neoantigens,
and
chimeric
antigen
receptors
T-cell
reprogramming.
RNA
interference
tools
enable
highly
effective
post-transcriptional
gene
silencing
that
has
progressed
towards
more
tailored
antitumor
treatments
targeting
key
molecular
players
tumor
progression
drug
resistance.
The
inherent
challenges
limitations
of
tools,
such
as
size,
low
stability
surface
charges
hindering
direct
cell
entry,
along
with
the
short
circulatory
half-life
rapid
clearance,
call
improved
delivery
systems
enabling
enhanced
delivery.
Nanoplatforms,
particularly
certain
types
lipid,
polymeric
nanoparticles
inorganic
nanoparticles,
provide
designed
means
to
address
cellular
uptake.
This
paper
explores
barriers
while
giving
insight
into
future
perspective
cancer
therapeutics
context
nanoplatforms
during
development.
International Reviews of Immunology,
Год журнала:
2022,
Номер
42(4), С. 287 - 303
Опубликована: Июль 6, 2022
Metabolic
reprogramming
is
a
hallmark
of
solid
cancers.
Macrophages
as
major
constituents
immune
system
take
important
roles
in
regulation
tumorigenesis.
Pro-tumor
M2
macrophages
preferentially
use
oxidative
phosphorylation
(OXPHOS)
to
meet
their
metabolic
demands,
while
anti-tumor
M1
glycolysis
dominant
source.
Dysregulation
systems
driving
force
skewing
from
toward
phenotypical
state.
Hyperactive
macrophages,
for
instance,
release
products
that
are
contributed
macrophage
polarization.
Thus,
remodeling
through
reinstating
normalization
can
be
an
effective
tool
cancer
therapy.
The
key
focus
this
review
over
and
factors
influencing
acquisition
cancer,
well
discussing
bout
strategies
adjust
metabolism
reeducation
M1-like
phenotype.
