Prognostic value of clinical parameters and exosomal lncRNA NEAT1_1 in MEN1‐related non‐functioning pancreatic neuroendocrine tumors DOI Creative Commons
Jerena Manoharan, Max B. Albers,

Natalia Khizanishvili

и другие.

Journal of Neuroendocrinology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Non-functioning pancreatic neuroendocrine tumors (NF-pNETs) significantly contribute to the premature death of multiple endocrine neoplasia type 1 (MEN1) patients. Reliable prognostic markers are not yet available. MicroRNAs (miRNA) and long-non-coding (lnc) RNAs, transported by extracellular vesicles, emerging as new tools. This study aimed analyze clinical characteristics, exosomal-miRNA 451 (exo-miR451) lnc-RNA nuclear paraspeckle assembly transcript (NEAT1_1, 3.7 kB) in mild aggressive courses MEN1-NFpNET disease. Patient characteristics were assessed regarding an course In addition, exo-miR451 exo-lnc-NEAT1_1 expression levels quantified serum RT-qPCR correlated with data. Immunohistochemistry results STAT3 (signal transducer activator transcription 3), regulated NEAT1, performed NF-pNET tissue expression. Among 66 MEN1 patients NF-pNETs, 13 (20%) had disease course. No significant differences patient observed between those (n = 13) 53) (all p > .5). Exosomal miRNA-451 was dysregulated 55% 23) cases, showing a trend toward higher upregulation group (36% vs. 19%), although this difference statistically (p .215). Exo-NEAT1_1 overexpressed 42% (16/38) patients, without groups .0523). However, exo-NEAT1_1 strongly immunohistochemical staining .001). Although no marker could be identified, we show for first time that STAT3-NEAT1 pathway plays role MEN1-associated tumorigenesis.

Язык: Английский

Prognostic value of clinical parameters and exosomal lncRNA NEAT1_1 in MEN1‐related non‐functioning pancreatic neuroendocrine tumors DOI Creative Commons
Jerena Manoharan, Max B. Albers,

Natalia Khizanishvili

и другие.

Journal of Neuroendocrinology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Non-functioning pancreatic neuroendocrine tumors (NF-pNETs) significantly contribute to the premature death of multiple endocrine neoplasia type 1 (MEN1) patients. Reliable prognostic markers are not yet available. MicroRNAs (miRNA) and long-non-coding (lnc) RNAs, transported by extracellular vesicles, emerging as new tools. This study aimed analyze clinical characteristics, exosomal-miRNA 451 (exo-miR451) lnc-RNA nuclear paraspeckle assembly transcript (NEAT1_1, 3.7 kB) in mild aggressive courses MEN1-NFpNET disease. Patient characteristics were assessed regarding an course In addition, exo-miR451 exo-lnc-NEAT1_1 expression levels quantified serum RT-qPCR correlated with data. Immunohistochemistry results STAT3 (signal transducer activator transcription 3), regulated NEAT1, performed NF-pNET tissue expression. Among 66 MEN1 patients NF-pNETs, 13 (20%) had disease course. No significant differences patient observed between those (n = 13) 53) (all p > .5). Exosomal miRNA-451 was dysregulated 55% 23) cases, showing a trend toward higher upregulation group (36% vs. 19%), although this difference statistically (p .215). Exo-NEAT1_1 overexpressed 42% (16/38) patients, without groups .0523). However, exo-NEAT1_1 strongly immunohistochemical staining .001). Although no marker could be identified, we show for first time that STAT3-NEAT1 pathway plays role MEN1-associated tumorigenesis.

Язык: Английский

Процитировано

0