PTEN: A Novel Diabetes Nephropathy Protective Gene Related to Cellular Senescence DOI Open Access
Kang Li,

Huidi Tang,

Xiaoqing Cao

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3088 - 3088

Опубликована: Март 27, 2025

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The current diagnostic and therapeutic approaches need to be improved. Cellular senescence has been implicated in pathogenesis DN, but its precise role remains unclear. This study aimed identify key pathogenic genes related cellular DN explore their potential as biomarkers. Using transcriptomic data from GEO datasets (GSE96804, GSE30122, GSE142025, GSE104948) senescence-related sourced GenAge database, we integrated multiple bioinformatics approaches, including differential expression analysis, weighted gene co-expression network analysis (WGCNA), machine learning protein-protein interaction (PPI), genes. PTEN was identified a gene. Immune infiltration revealed that positively correlated with macrophage M2 dendritic cell resting negatively monocytes neutrophils. snRNA mainly expressed mesangial cells. Finally, RT-PCR results mRNA upregulated kidneys db/db mice. Additionally, high-glucose treatment significantly cultured human identifies biomarker for which may contribute early detection personalized strategies.

Язык: Английский

Autophagy: regulating the seesaw of bone–fat balance DOI Creative Commons
Boya Zhang, Jing Cui, Xu Zhang

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 24, 2025

The interrelationship between bone and fat can be described as a seesaw in homeostasis, which both osteogenesis adipogenesis occur delicate balance. Osteoblasts adipocytes share common origin play key roles adipogenesis. Bone-fat balance indicates keeps for concordant distribution of trabecular marrow adipose tissue bone, thereby leading to the metabolism lipid metabolism. is crucial metabolic health. When disrupted by various factors, this lead several bone-related diseases systemic disorders, such obesity, osteoporosis, osteoarthritis. Recent research highlights role autophagy dysfunction these conditions. Restoring autophagic function help restore homeostasis re-establish bone-fat current review explores factors that regulate balance, consequences imbalance under pathological conditions, potential modulation therapeutic approach. Overall, it concluded targeting presents promising strategy treating disorders restoring

Язык: Английский

Процитировано

0
PTEN: A Novel Diabetes Nephropathy Protective Gene Related to Cellular Senescence DOI Open Access
Kang Li,

Huidi Tang,

Xiaoqing Cao

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3088 - 3088

Опубликована: Март 27, 2025

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The current diagnostic and therapeutic approaches need to be improved. Cellular senescence has been implicated in pathogenesis DN, but its precise role remains unclear. This study aimed identify key pathogenic genes related cellular DN explore their potential as biomarkers. Using transcriptomic data from GEO datasets (GSE96804, GSE30122, GSE142025, GSE104948) senescence-related sourced GenAge database, we integrated multiple bioinformatics approaches, including differential expression analysis, weighted gene co-expression network analysis (WGCNA), machine learning protein-protein interaction (PPI), genes. PTEN was identified a gene. Immune infiltration revealed that positively correlated with macrophage M2 dendritic cell resting negatively monocytes neutrophils. snRNA mainly expressed mesangial cells. Finally, RT-PCR results mRNA upregulated kidneys db/db mice. Additionally, high-glucose treatment significantly cultured human identifies biomarker for which may contribute early detection personalized strategies.

Язык: Английский

Процитировано

0