Study of the relationship between iron metabolism disorders and sepsis-associated liver injury: A prospective observational study DOI
Tianwei Wang, Lulu Zhou, Jing Yuan

и другие.

World Journal of Gastroenterology, Год журнала: 2025, Номер 31(14)

Опубликована: Апрель 9, 2025

Sepsis-associated liver injury (SALI) refers to secondary function impairment caused by sepsis, patients with SALI often have worse clinical outcomes. The early identification and assessment of the occurrence progression are pressing issues that urgently need be resolved. To investigate relationship between iron metabolism SALI. In this prospective study, 139 were recruited, 53 assigned group. relationships various metabolism-related biomarkers examined. These included serum (SI), total iron-binding capacity (TIBC), ferritin, transferrin, transferrin saturation. identify independent risk factors for SALI, both univariate multivariate logistic regression analyses performed. Additionally, receiver operating characteristic curve analysis was utilized assess predictive value these There no statistically significant differences in age, sex, body mass index, Sequential Organ Failure Assessment scores (excluding function), or APACHE II two groups patients. Compared sepsis group, group presented significantly higher SI (P < 0.001), TIBC ferritin = 0.005), saturation levels 0.001). Multivariate revealed (odds ratio 1.24, 95% confidence interval: 1.11-1.40, P 0.001) 1.13, 1.05-1.21, predictors Receiver had areas under 0.816 0.757, respectively, indicating moderate accuracy Iron disorders closely associated development may serve as potential biomarkers. combined use has superior diagnostic efficacy findings provide valuable insights management among sepsis.

Язык: Английский

Study of the relationship between iron metabolism disorders and sepsis-associated liver injury: A prospective observational study DOI
Tianwei Wang, Lulu Zhou, Jing Yuan

и другие.

World Journal of Gastroenterology, Год журнала: 2025, Номер 31(14)

Опубликована: Апрель 9, 2025

Sepsis-associated liver injury (SALI) refers to secondary function impairment caused by sepsis, patients with SALI often have worse clinical outcomes. The early identification and assessment of the occurrence progression are pressing issues that urgently need be resolved. To investigate relationship between iron metabolism SALI. In this prospective study, 139 were recruited, 53 assigned group. relationships various metabolism-related biomarkers examined. These included serum (SI), total iron-binding capacity (TIBC), ferritin, transferrin, transferrin saturation. identify independent risk factors for SALI, both univariate multivariate logistic regression analyses performed. Additionally, receiver operating characteristic curve analysis was utilized assess predictive value these There no statistically significant differences in age, sex, body mass index, Sequential Organ Failure Assessment scores (excluding function), or APACHE II two groups patients. Compared sepsis group, group presented significantly higher SI (P < 0.001), TIBC ferritin = 0.005), saturation levels 0.001). Multivariate revealed (odds ratio 1.24, 95% confidence interval: 1.11-1.40, P 0.001) 1.13, 1.05-1.21, predictors Receiver had areas under 0.816 0.757, respectively, indicating moderate accuracy Iron disorders closely associated development may serve as potential biomarkers. combined use has superior diagnostic efficacy findings provide valuable insights management among sepsis.

Язык: Английский

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