Vaccines, Год журнала: 2024, Номер 12(11), С. 1263 - 1263
Опубликована: Ноя. 8, 2024
The vast, untapped potential of the world's oceans is revealing groundbreaking advancements in human health and vaccination. Microalgae such as
Язык: Английский
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102727 - 102727
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2
Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
0
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104721 - 104721
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Molecular Biomedicine, Год журнала: 2025, Номер 6(1)
Опубликована: Апрель 25, 2025
Abstract Over the past few decades, obesity has transitioned from a localized health concern to pressing global public crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As chronic metabolic disorder characterized pathological adipose tissue expansion, inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis impairs physiological functions, is rarely an isolated condition; rather, it frequently complicated severe comorbidities collectively elevate mortality risks. Despite advances in nutritional science initiatives, sustained weight management success rates prevention remain limited, underscoring its recognition multifactorial disease influenced genetic, environmental, behavioral determinants. Notably, escalating prevalence of earlier onset younger populations have intensified urgency develop novel therapeutic agents simultaneously ensure efficacy safety. This review aims elucidate pathophysiological mechanisms underlying obesity, analyze major complications—including type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), non-alcoholic fatty liver (NAFLD), obesity-related respiratory disorders, nephropathy (ORN), musculoskeletal impairments, malignancies, psychological comorbidities—and critically evaluate current anti-obesity strategies. Particular emphasis placed on emerging pharmacological interventions, exemplified plant-derived natural compounds such berberine (BBR), with focus their molecular mechanisms, clinical efficacy, advantages. By integrating mechanistic insights evidence, this seeks provide innovative perspectives for developing safe, accessible, effective treatments.
Язык: Английский
Процитировано
0
Chemistry & Biodiversity, Год журнала: 2025, Номер unknown
Опубликована: Май 26, 2025
ABSTRACT To date, metabolites of cryptomonads from the South China Sea have not been investigated. Herein, four new highly‐oxidized steroids, named rhodomonasterols A–D ( 1–4 ), which compounds 1 , 2 and 4 possess a long‐conjugated carbon chain, were obtained cryptomonad Rhodomonas sp. The structures absolute configurations these steroids unambiguously established by high‐resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, single‐crystal X‐ray diffraction analyses (Cu–Kα). Notably, exhibited inhibitory activities against production nitric oxide (NO) in lipopolysaccharide‐induced BV2 cells at concentration 10.0 µM. two inhibited expression inducible NO synthase, thereby displaying anti‐inflammatory effects.
Язык: Английский
Процитировано
0
Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Myocardial ischemia-reperfusion injury (MIRI) constitutes an essential hurdle following reperfusion therapy for acute myocardial infarction (AMI), which the mechanism involves oxidative stress, inflammatory response, calcium overload, and ferroptosis, etc. MAQAAEYYR (P2), a kind of marine-derived bioactive peptide from C-Phycocyanin (C-PC), exhibits remarkable antioxidant properties. Due to its low molecular weight, P2 superior bioavailability compared C-PC. A previous study has confirmed that C-PC could alleviate (I/R)-induced cardiac dysfunction. However, whether derived potential protect heart against deserves consideration investigation. In this study, C57BL/6 male mice H9C2 cardiomyocytes were used construct (MI/R) oxygen-glucose deprivation/recovery (OGD/R) models in vivo vitro respectively. We demonstrated significantly improved function, enzymes, fibrosis, mitochondrial ultrastructure, while mitigating stress damage ferroptosis caused by MI/R. vitro, markedly enhanced cell viability, suppressed generation reactive oxygen species (ROS) malondialdehyde (MDA), elevated glutathione (GSH) superoxide dismutase (SOD) levels, prevented occurrence ferroptosis. Furthermore, we revealed ubiquitin carboxyl terminal hydrolase L3 (UCHL3) knockdown reversed protective effect OGD/R-induced cardiomyocyte This protects myocardium mitigates upregulating UCHL3. It provides foundation application prospects peptides cardiovascular disease management.
Язык: Английский
Процитировано
0
International Journal of Cardiology, Год журнала: 2024, Номер 411, С. 132283 - 132283
Опубликована: Июнь 20, 2024
Процитировано
2
Marine Drugs, Год журнала: 2024, Номер 22(5), С. 213 - 213
Опубликована: Май 7, 2024
Marine sponges of the genus Spongia have proven to be unabated sources novel secondary metabolites with remarkable scaffold diversities and significant bioactivities. The discovery chemical substances from has continued increase over last few years. current work provides an up-to-date literature survey comprehensive insight into reported members Spongia, as well their structural features, biological activities, structure–activity relationships when available. In this review, 222 are discussed based on published data period mid-2015 beginning 2024. compounds categorized sesquiterpenes, diterpenes, sesterterpenes, meroterpenes, linear furanoterpenes, steroids, alkaloids, other miscellaneous substances. effects these compositions a vast array pharmacological assays including cytotoxic, anti-inflammatory, antibacterial, neuroprotective, protein tyrosine phosphatase 1B (PTP1B)-inhibitory, phytoregulating activities also presented.
Язык: Английский
Процитировано
1
Scientia Pharmaceutica, Год журнала: 2024, Номер 93(1), С. 2 - 2
Опубликована: Дек. 26, 2024
Although COVID-19 is not a pandemic anymore, the virus frequently mutates, resulting in new strains and presenting global public health challenges. The lack of oral antiviral drugs makes it difficult to treat him, which creation broadly acting antivirals necessary fight current next epidemics viruses. Using molecular docking approach, 118 compounds derived from marine organisms 92 previously synthesized were screened assess their binding affinity for main protease papain-like enzymes SARS-CoV-2. best candidates xanthene, benzoxazole, coumarin classes identified. Marine-derived showed slightly better potential as enzyme inhibitors, though affinities similar, with displaying values between 0.2 0.4 mM. Xanthenes, among both origin compounds, emerged most promising scaffolds further research inhibitors. was found be more druggable than protease. Additionally, all top met criteria various drug-likeness properties, indicating good bioavailability low risk adverse effects. This provides valuable insights into comparative coumarin, benzoxazole classes, highlighting vitro vivo studies.
Язык: Английский
Процитировано
1
Vaccines, Год журнала: 2024, Номер 12(11), С. 1263 - 1263
Опубликована: Ноя. 8, 2024
The vast, untapped potential of the world's oceans is revealing groundbreaking advancements in human health and vaccination. Microalgae such as
Язык: Английский
Процитировано
0