The gut microbiome across the lifespan: how diet modulates our microbial ecosystem from infancy to the elderly
International Journal of Food Sciences and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 19, 2024
This
comprehensive
review
examines
the
impact
of
dietary
patterns
on
gut
microbiome
composition
and
diversity
from
infancy
to
old
age,
linking
these
changes
age-related
health
outcomes.
It
investigates
how
develops
across
life
stages,
focusing
influence
factors.
The
explores
early-life
feeding
practices,
including
breastfeeding
formula
feeding,
shape
infant
microbiota
have
lasting
effects.
In
elderly
individuals,
alterations
in
are
associated
with
increased
susceptibility
infections,
chronic
inflammation,
metabolic
disorders
cognitive
decline.
critical
role
diet
modulating
throughout
is
emphasised,
particularly
potential
benefits
probiotics
fortified
foods
promoting
healthy
ageing.
By
elucidating
mechanisms
connecting
food
systems
health,
this
provides
insights
into
interventions
that
could
enhance
resilience
improve
outcomes
lifespan.
Язык: Английский
The Exposome and the Kidney: A Silent Dialogue Shaping Chronic Kidney Disease
Journal of Xenobiotics,
Год журнала:
2025,
Номер
15(3), С. 73 - 73
Опубликована: Май 14, 2025
Genetic
predisposition
accounts
for
less
than
20%
of
the
global
disease
burden,
highlighting
substantial
role
environmental
factors
in
health
outcomes.
In
chronic
kidney
(CKD),
a
growing
prevalence,
understanding
interplay
between
genes
and
environment
is
crucial.
Emerging
research
exposome
genome
underscores
how
exposures
interact
with
genetic
variants
to
influence
development
progression
CKD.
The
term
"exposome"
encompasses
variety
factors,
including
personal
behaviors
like
smoking,
sedentary
lifestyle,
making
specific
dietary
choices
(such
as
consuming
ultra-processed
foods,
sugar,
or
fat).
It
also
includes
broader
determinants
such
pesticides,
air,
water,
soil
pollution,
nanoplastics,
warming,
stressful
life
events,
socioeconomic
status.
Research
on
significantly
increases
our
toxicological
processes
individual
variations
susceptibility
stressors.
This
narrative
review
aims
explore
associated
CKD,
highlight
key
its
development,
discuss
potential
preventive
therapeutic
strategies
informed
by
these
exposure-related
factors.
Язык: Английский
Potential Trimethylamine (TMA)-Producing Bacteria in patients with chronic kidney disease undergoing hemodialysis
International Urology and Nephrology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 31, 2024
Язык: Английский
Effects of dietary compounds on nuclear factor erythroid 2-related factor 2 (Nrf2) modulation in chronic kidney disease: a systematic review of clinical trials
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 20
Опубликована: Июль 31, 2024
Nuclear
factor-erythroid
2-related
factor
2
(Nrf2)
is
an
important
transcription
that
activates
antioxidant
genes
and
increases
detoxifying
enzymes.
Studies
have
shown
dietary
compounds
can
activate
the
Nrf2
expression
improve
response
in
patients
with
exacerbated
oxidative
stress,
such
as
chronic
kidney
disease
(CKD).
We
aimed
to
evaluate
efficacy
of
nutritional
interventions
on
phase
II
enzymes
clinical
trials
CKD.
searched
PubMed,
Lilacs,
Embase,
Scopus,
Cochrane
Library
databases
published
tool
was
used
for
quality
assessment
studies
included.
reported
this
review
according
PRISMA
it
registered
PROSPERO
(42023389619).
Thirty-nine
were
included
review;
nine
evaluated
three
showed
increase
its
expression.
Twenty-three
found
enzyme
levels,
including
superoxide
dismutase,
catalase,
glutathione
peroxidase.
Moreover,
a
high
risk
bias
most
heterogeneity
designs,
type,
duration
supplementation
administered.
These
results
suggest
supplementations
promising
effect
response,
however,
recommended
further
should
be
carried
out.
Язык: Английский