A diet-driven metabolic dysfunction-associated steatohepatitis (MASH) mouse model resembles the corresponding human disease DOI
Guilherme Ribeiro Romualdo, Letícia Cardoso Valente, Gabriel Bacil Prata

и другие.

Journal of Molecular Histology, Год журнала: 2025, Номер 56(3)

Опубликована: Май 20, 2025

Язык: Английский

Therapeutic intervention with anti-TNF alleviates colonic and hepatic toxicity induced by perfluorooctanoic acid (PFOA) DOI

Wei Li,

Yongjing Qian,

Xiaojing Cai

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 296, С. 118125 - 118125

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

0
Systematic review on effectiveness of flavonoids against hypercholesterolemia: Insights from in-silico, in-vitro, and in-vivo studies DOI

Nurnazira Hanis,

Nurul Azira Ismail, Ernie Zuraida Ali

и другие.

Food Chemistry Advances, Год журнала: 2025, Номер 7, С. 100981 - 100981

Опубликована: Апрель 21, 2025

Язык: Английский

Процитировано

0
Development of SOCS1 Mimetics as Novel Approach to Harmonize Inflammation, Oxidative stress, and Fibrogenesis in Metabolic Dysfunction-Associated Steatotic Liver Disease. DOI Creative Commons

Susana Bernal,

Ignacio Priéto,

María Kavanagh

и другие.

Redox Biology, Год журнала: 2025, Номер 84, С. 103670 - 103670

Опубликована: Май 11, 2025

Язык: Английский

Процитировано

0
The role of gut microbiota in modulating immune responses in chronic liver disease: a systematic review and meta-analysis DOI Creative Commons

Eyad Gadour,

Khalid Shrwani,

Zeinab Hassan

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 16, 2025

Introduction The gut microbiota plays a crucial role in regulating immune responses and maintaining balance within the gut-liver axis. In patients with chronic liver disease (CLD), alterations have been linked to progression impaired function. This study aimed evaluate impact of gut-modulating therapies on CLD. Method Two independent authors conducted comprehensive literature search using complementary strategies identify relevant articles published until March 2025. Review Manager Software (RevMan 5.4) was used for data analysis, results were presented forest plots. Results Of 373 identified studies, 16 included analysis. findings revealed that microbiota-modulating significantly reduced tumor necrosis factor-α (TNF-α) levels compared control interventions (standardized mean difference [SMD], -0.60; 95% confidence interval [CI] [-0.93, -0.23] p = 0.001), similar observed at 6-month follow-up (SMD -1.3; CI [-2.1, -0.4] 0.004). Interleukin-6 (IL-6) showed no significant change between groups (SMD, -0.67; [-1.5, 0.12) 0.09). C-reactive protein (CRP) by -1.057; [-1.493, -0.621] 0.0005), consistent 1- follow-up. Changes interferon-gamma (IFN-γ) IL-18 cellular immunity also assessed. Conclusion highlights importance modulating CLD demonstrates effectiveness long-term reducing inflammatory markers. While CRP TNF-α decreased, changes IL-6 inconsistent, warranting further research elucidate this biomarker.

Язык: Английский

Процитировано

0
A diet-driven metabolic dysfunction-associated steatohepatitis (MASH) mouse model resembles the corresponding human disease DOI
Guilherme Ribeiro Romualdo, Letícia Cardoso Valente, Gabriel Bacil Prata

и другие.

Journal of Molecular Histology, Год журнала: 2025, Номер 56(3)

Опубликована: Май 20, 2025

Язык: Английский

Процитировано

0