Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)
Опубликована: Апрель 16, 2025
Язык: Английский
Osteoarthritis and Cartilage, Год журнала: 2024, Номер 32(4), С. 452 - 459
Опубликована: Фев. 12, 2024
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, predominant use of body mass index (BMI) to define obesity in OA research associated with uncertainties and limitations. These include inability discern fat muscle mass, account sex-differences distribution, or identify adiposityrelated health impairments. A focus on BMI may influence weight bias clinical practice impact disparities access effective treatments. To ensure that our understanding approaches improve outcomes individuals at risk continues advance next decade, future will need consider alternative measures beyond identification align evolving science. researchers must be aware issues stigma work minimize negative generalizations based BMI.
Язык: Английский
Процитировано
17
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 1207 - 1233
Опубликована: Янв. 1, 2025
Osteoarthritis (OA) affects several joints but tends to be more prevalent in those that are weight-bearing, such as the knees, which most heavily loaded body. The incidence and disability rates of OA have continued increase seriously jeopardise quality life middle-aged older adults. However, is than just a wear tear disease; its aetiology complex, pathogenesis poorly understood. Metabolic syndrome (MetS) has emerged critical driver development. This condition contributes formation distinct phenotype, termed metabolic syndrome-associated osteoarthritis (MetS-OA),which differs from other metabolically related diseases by unique pathophysiological mechanisms clinical presentation. As key mediators MetS, adipokines leptin, lipocalin, resistin regulate inflammation bone metabolism through or synergistic signaling pathways. Their modulation inflammatory responses remodeling processes plays role progression OA. Due their central regulating remodeling, not only deepen our understanding MetS-OA also represent promising targets for novel therapeutic strategies could slow disease improve outcomes affected patients.
Язык: Английский
Процитировано
2
Journal of Orthopaedic Translation, Год журнала: 2024, Номер 47, С. 116 - 124
Опубликована: Июнь 22, 2024
Osteoarthritis (OA) is one of the most common disabling pathologies, characterized by joint pain and reduced function, significantly worsening quality life. Even if important progresses have been made in OA research, little yet known about precise cellular molecular mechanisms underlying OA. Understanding dysregulated signaling networks their crosstalk may offer a strong opportunity for development combined targeted therapies. Hence, this review highlights recent findings on main pathways involved development, including Wnt, Notch, Hedgehog, MAPK, AMPK, JAK/STAT, providing insights current therapies patients' management. The identification key investigation could pave way more effective treatments improved management patients future.
Язык: Английский
Процитировано
8
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 2, 2025
Osteoarthritis (OA) is a multi-factorial degenerative joint disease with unclear pathogenesis. Conservative treatments, primarily aimed at pain relief, fail to halt progression. Metabolic syndrome has recently been implicated in OA pathogenesis, underscoring the need for novel therapeutic strategies. Arctiin (ARC), lignan known its anti-inflammatory and anti-osteoporotic properties, potential effects on that merit exploration. We assessed ARC's impact chondrocyte viability using Cell Counting Kit-8 toluidine blue staining glycosaminoglycan presence. Gene protein expression were analyzed via RT-PCR, Western blotting, immunofluorescence. An rat model was employed vivo evaluations through histological assessments micro-CT scanning. ARC reversed IL-1β-induced upregulation of MMP3, MMP13, COX-2 downregulation collagen II SOX9. It modulated cholesterol metabolism IL-1β-stimulated chondrocytes by inhibiting CH25H-CYP7B1-RORα axis, reducing cartilage damage proteoglycan loss rats, effectively subchondral bone osteolysis. inhibits inflammatory responses ECM degradation, suggesting as agent OA. acts partly modulating suppressing CH25H/CYP7B1/RORα axis chondrocytes.
Язык: Английский
Процитировано
1
Journal of Orthopaedic Translation, Год журнала: 2025, Номер 50, С. 56 - 70
Опубликована: Янв. 1, 2025
Osteoarthritis (OA) is a progressive degenerative disease affected by many factors, and there currently no effective treatment. In recent years, the latest progress in metabolomics OA research has revealed several metabolic pathways new specific metabolites involved OA. Metabolites play significant roles identification management of This review looks back on development history this technology as well its potential clinical applications. It summarizes applications field future directions. understanding will advance treatment goals for The offers possibilities article reviews relationship between associated with chondrocytes Selectively altering these three their may hold great focal points
Язык: Английский
Процитировано
1
Medicine, Год журнала: 2025, Номер 104(4), С. e41335 - e41335
Опубликована: Янв. 24, 2025
Osteoarthritis (OA) is a chronic joint condition affecting millions worldwide, characterized by the gradual degeneration of cartilage, leading to pain, stiffness, and functional impairment. Although pathogenesis OA not fully understood, roles inflammation, metabolic dysregulation, biomechanical stress are increasingly recognized. Current treatments, including pharmacotherapy, physical therapy, surgical interventions, aim alleviate symptoms improve quality life, yet they face limitations challenges. In recent years, researchers have explored variety new treatment strategies, such as molecular targeted biologic regenerative medicine, lifestyle modifications, aiming directly address root causes complex mechanisms OA. This review aims summarize latest research advancements provide fresh perspectives for clinical lay foundation future development strategies
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Фев. 13, 2025
Osteoarthritis is a degenerative joint disorder characterized by cartilage degradation, synovial inflammation, and altered subchondral bone structure. Recent insights have identified mitochondrial dysfunction as pivotal factor in OA pathogenesis, contributing to chondrocyte apoptosis, oxidative stress, extracellular matrix degradation. Disruptions dynamics, including impaired biogenesis, mitophagy, metabolic shifts from phosphorylation glycolysis, exacerbate damage promoting the production of reactive oxygen species matrix-degrading enzymes such ADAMTS MMPs. This review explores molecular mechanisms underlying OA, emphasizing its role homeostasis inflammation. Furthermore, it highlights emerging therapeutic strategies targeting pathways, antioxidants, mitophagy enhancers, modulators, potential interventions mitigate disease progression, which offer promising avenues for advancing personalized disease-modifying treatments OA.
Язык: Английский
Процитировано
1
Journal of Orthopaedic Translation, Год журнала: 2025, Номер 51, С. 207 - 217
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Gels, Год журнала: 2024, Номер 10(7), С. 430 - 430
Опубликована: Июнь 28, 2024
Articular cartilage is an avascular tissue with very limited capacity of self-regeneration. Trauma or injury-related defects, inflammation, aging in articular can induce progressive degenerative joint diseases such as osteoarthritis. There are significant clinical demands for the development effective therapeutic approaches to promote repair regeneration. The current treatment modalities used lesions mainly include cell-based therapy, small molecules, surgical approaches, and engineering. However, these remain unsatisfactory. With advent three-dimensional (3D) bioprinting technology, engineering provides opportunity defects degeneration through construction organized, living structures composed biomaterials, chondrogenic cells, bioactive factors. bioprinted cartilage-like mimic native cartilage, opposed traditional by allowing excellent control cell distribution modulation biomechanical biochemical properties high precision. This review focuses on various hydrogels, including natural synthetic their developments bioinks 3D In addition, challenges prospects hydrogels applications also discussed.
Язык: Английский
Процитировано
5
Life Sciences, Год журнала: 2024, Номер 354, С. 122947 - 122947
Опубликована: Авг. 8, 2024
Язык: Английский
Процитировано
4