Oxidative balance score is independently associated with reduced prevalence of sarcopenia among US adults with metabolic syndrome

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 8, 2025

This research seeks to explore the link between oxidative balance score (OBS) and sarcopenia in American adults with Metabolic Syndrome (MetS) using data from a national, population-based survey. The study included 3,625 participants diagnosed Syndrome, all aged 20 years above, derived NHANES datasets spanning 1999-2006 2011-2018. OBS evaluation was based on 16 dietary 4 lifestyle elements. MetS diagnosis followed NCEP-ATP III guidelines, while identification FNIH standards. We employed multivariate logistic regression analyses delve into connections within cohort. Sarcopenia found 17.46% of participants. In models adjusted for variables, OBS, each showed significant inverse relationship among individuals [OBS: OR = 0.959, 95%CI: (0.948, 0.982), P trend 0.0005; OBS: 0.963, (0.939, 0.989), 0.0055; 0.860, (0.787, 0.939), 0.0011]. Higher scores were consistently linked decreased incidence (all < 0.05). Restricted cubic spline analysis confirmed that these relationships linear. impact age significant, benefits only observed those 40 older. Maintaining diet rich antioxidants is both independently collectively lower occurrence MetS. These results bolster proposition developing OBS-centered preventive strategies patients, particularly

Язык: Английский

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Osteoarthritis is a risk factor for renal function injury based on the National Health and Nutrition Examination Survey and Mendelian Randomized study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 12, 2025

This study aims to investigate the association and causality between osteoarthritis (OA) chronic kidney disease (CKD) using data from National Health Nutrition Examination Survey (NHANES) Mendelian Randomization (MR) analysis. Participants with OA, urinary albumin, creatinine, albumin-to-creatinine ratio (UACR), blood estimated glomerular filtration rate (eGFR) were selected NHANES. CKD was calculated CKD-EPI equation, logistic regression assessed by OA-CKD association. A two-sample MR analysis conducted Genome-wide studies (GWAS) for hip OA (HOA), knee (KOA), acute renal failure (ARF), (CRF), cystatin C, serum creatinine (eGFRcrea), microalbuminuria. The inverse variance weighted (IVW) method used, heterogeneity, sensitivity, pleiotropy assessments. cross-sectional showed a significant positive [unadjusted OR: 2.398 (95% CI: 2.176-2.643), p < 0.001], which persisted after adjustment demographic factors, socioeconomic status, lifestyle medical history [adjusted 1.161 1.029-1.310), = 0.015]. revealed no causal relationship overall function markers but found genetic HOA C [IVW 0.0014, OR 1.02, 95% 1.01-1.03], KOA 0.0001, 1.06, 1.04-1.08]. Our indicates that are risk factors injury, providing new insights clinical management.

Язык: Английский

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Opportunities for optimizing therapy in the metabolic phenotype of osteoarthritis

Meditsinskiy sovet = Medical Council, Год журнала: 2025, Номер 3, С. 134 - 143

Опубликована: Апрель 12, 2025

Osteoarthritis (OA) is an extremely heterogeneous disease. Identifying a specific disease phenotype will help the practitioner optimize approaches to diagnosis and treatment. The metabolic of OA associated with greatest polyand comorbidity, which significantly limit choice number drugs often used in treatment this joint pathology. presented clinical observation demonstrates difficulties care patient combination eleven somatic diseases at same time, one was OA. Care tactics suggest, on hand, justified polypragmasy, other low adherence long–term use large drugs. presence many comorbid diseases, particular coronary heart disease, history stroke, suggest complete rejection nonsteroidal anti-inflammatory (with exception local forms). Regular therapy bioactive extract from small marine fish last two years has made it possible achieve improvement and, probably, prevent radiographic progression knee delay replacement surgery.

Язык: Английский

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Dissemination of obesity-related short videos on TikTok: content analysis

Deleted Journal, Год журнала: 2025, Номер 22(1)

Опубликована: Апрель 15, 2025

Язык: Английский

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Association between conicity index (C-index), relative fat mass (RFM), and osteoarthritis (OA): evidence from NHANES 2003–2018

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 16, 2025

Язык: Английский

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