Consensus Guidelines for the Diagnosis and Management of Metabolic Dysfunction-Associated Steatotic Liver Disease in Adult Asian Indians with Type 2 Diabetes

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2025, Номер 19(3), С. 103209 - 103209

Опубликована: Март 1, 2025

Язык: Английский

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Lifestyle interventions in cardiometabolic HFpEF: dietary and exercise modalities

Heart Failure Reviews, Год журнала: 2024, Номер unknown

Опубликована: Сен. 16, 2024

Abstract Heart failure with preserved ejection fraction (HFpEF) is rapidly growing as the most common form of heart failure. Among HFpEF phenotypes, cardiometabolic/obese — driven by cardiometabolic alterations emerges one prevalent forms this syndrome and on which recent therapeutic success have been made. Indeed, pharmacological approaches sodium-glucose cotransporter type 2 inhibitors (SGLT2i) glucagon-like peptide-1 receptor agonists (GLP-1RA) proved to be effective due metabolic protective effects. Similarly, lifestyle changes, including diet exercise are crucial in management. Increasing evidence supports important role physical activity pathogenesis, prognosis, potential reversal HFpEF. Metabolic derangements systemic inflammation key features represent main targets interventions. However, underlying mechanisms beneficial effects these interventions incompletely understood. Hence, there an unmet need tailored intervention modalities for patients Here we present current available management therapeutics, discussing their mechanisms.

Язык: Английский

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Dietary vitamin D intake and changes in body composition over three years in older adults with metabolic syndrome

The journal of nutrition health & aging, Год журнала: 2025, Номер 29(3), С. 100467 - 100467

Опубликована: Янв. 8, 2025

Язык: Английский

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Training modalities for elder sarcopenic obesity: a systematic review and network meta-analysis

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 19, 2025

Sarcopenic obesity (SO) is a condition characterized by the coexistence of age-related and sarcopenia. This systematic review network meta-analysis (NMA) aimed to compare effects different training modalities, such as aerobic (AT), resistance (RT), combined with AT (CT), multicomponent (MCT) on body composition, muscle strength, physical performance in elderly patients SO. We electronically searched randomized controlled trials, published from inception March 2024 PubMed, Embase, Cochrane Library, Web Science Scopus. Effect estimates were presented mean differences (MD) or Standard Mean Difference (SMD) 95% confidence interval (CI). The comprehensive all treatments ranked surface under cumulative ranking (SUCRA) probabilities. 14 trials enrolling 955 participants included. fat percentage (BFP) MCT (MD= -6.37, CI: -8.67, -4.07), CT (MD = -2.08, -4.00, -0.16), RT -1.85, -3.25, -0.44) was significantly lower than normal control group, showing superior compared RT. Furthermore, only improved fat-free mass (FFM; MD 5.21, CI:1.51, 8.91), well index (BMI; 0.74, CI:0.08, 1.40). In addition, handgrip strength (HGS) both (SMD 0.87, 0.19, 1.5) RT(SMD 0.84, 0.43, 1.25). 30s chair stand test also yielded better outcomes for 3.10, 1.33, 4 0.86), CT(MD 2 0.50, 0.18, 5.18), RT(MD 3.91, 2.30, 5.52) when group. Lastly, gait speed enhanced 0.35, 0.30, 0.41) 0.14, 0.06, 0.21). results indicated that other modalities enhancing composition speed. contrast, appears be more advantageous 30-second standing improving HGS. outperformed beneficial These findings provide valuable insights clinicians researchers customize exercise prescriptions older http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42024544962.

Язык: Английский

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Serum concentrations of irisin, erythroferrone, myostatin and interleukin-6 in obese patients depending on the presence of sarcopenia

Russian Journal of Preventive Medicine, Год журнала: 2025, Номер 28(2), С. 67 - 67

Опубликована: Фев. 27, 2025

Objective. To characterize and compare myokine profiles in patients with obesity depending on the presence of sarcopenia. Materials Methods. The study included 77 examined at National Medical Research Center for Therapy Preventive Medicine Ministry Health Russia from January 2023 to April 2024. Sarcopenia was diagnosed using criteria including handgrip strength, skeletal muscle mass, physical function assessment. Serum erythroferrone, irisin, myostatin, interleukin (IL)-6 were assessed enzyme-linked immunosorbent assay. Results. Thirteen (16.9%) demonstrated reduced strength; 22 participants had decreased appendicular mass body (AMM/BM) ratio. AMM value correlated serum concentrations irisin (ρ=0.297; p<0.009) erythroferrone (ρ=0.229; p<0.045). significantly differed strength dominant hand (p=0.038), (p=0.036), index (ASMI, p=0.007). IL-6 higher impaired (slower 4 m walking speed, p=0.073). Conclusion. In patient obesity, sarcopenia is associated profile alterations. This could be due disrupted structure, quantity, disturbed muscles

Язык: Английский

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Exercise, Nutrition, and Neuromuscular Electrical Stimulation for Sarcopenic Obesity: A Systematic Review and Meta-Analysis of Management in Middle-Aged and Older Adults

Nutrients, Год журнала: 2025, Номер 17(9), С. 1504 - 1504

Опубликована: Апрель 29, 2025

Background/Objective: Sarcopenic obesity (SO), a pathological syndrome characterized by the co-existence of diminished muscle mass and excessive adipose accumulation, significantly compromises quality life in older adults. The purpose this study was to systematically evaluate efficacy exercise, nutritional interventions, neuromuscular electrical stimulation (NMES) preventing managing SO middle-aged Methods: A comprehensive search conducted across PubMed, Web Science, Embase, Cochrane Library, CNKI for randomized controlled trials (RCTs) until January 2025. Meta-analyses were performed using random-effects model fixed-effects based on degree heterogeneity calculating mean differences (MD) with 95% confidence intervals (CI). Subgroup analyses compared intervention types. Results: Twenty-nine RCTs (1622 participants) included. Exercise interventions reduced body fat percentage (MD = −2.79%, CI: −3.94, −1.64, p < 0.001, I2 74%), −6.77 kg, −11.48, −2.06, 0.005, 98%), waist circumference −2.05 cm, −3.64, −0.46, 0.01, 0%) LDL-C (MD: −7.45 mg/dL, −13.82, −1.07, 0.02, 0%), while improving handgrip strength 2.35 1.99, 2.70, 52%) gait speed 0.19 m/s, 0.13, 0.24, 89%). Mixed training outperformed resistance-only regimens reducing enhancing functional outcomes. NMES −2.01%, −3.54, −0.48, 93%) −1.72 −2.35, −1.09, increasing Skeletal Muscle Index 0.26 kg/m2, 0.22, 0.29, 38%). Synergy supplementation amplified these effects. Nutritional modestly improved total fat-free 0.77 0.04, 1.50, 1.35 0.71, 2.00, but showed no significant impact metabolic markers (TG, TC, glucose, hemoglobin, HOMA-IR). Conclusions: Exercise, particularly multimodal combining aerobic resistance training, is cornerstone composition physical function SO. serves as an effective adjunct accelerating loss, strategies require integration exercise or prolonged implementation yield clinically meaningful Future research should prioritize standardized diagnostic criteria long-term assessments interventions.

Язык: Английский

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Sarcopenic obesity and weight loss-induced muscle mass loss

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Purpose of review Sarcopenic obesity is a clinical condition characterized by the coexistence excess adiposity and impaired muscle function, associated with heightened cardiometabolic risk frailty. The emergence new incretin-based management medications (OMMs), which allow unprecedented weight loss, has raised concerns regarding loss-induced fat-free mass (FFM) reduction, including skeletal (SMM). This examines recent findings on prevalence, diagnosis, implications sarcopenic obesity, explores effects weight-loss interventions body composition their impact health, discusses strategies to preserve mass. Recent Weight loss induced OMMs results in variable but significant reduction FFM. extent this affects SMM function remains uncertain. Nutritional strategies, particularly adequate protein intake, structured exercise interventions, especially resistance training, play key role mitigating FFM loss. Digital health telemedicine-based programs offer promising approaches for maintaining during Summary significance debated. Future research should refine diagnostic criteria, assess long-term FFM/SMM intentional evaluate that optimize while preserving functional health.

Язык: Английский

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Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999–2004 and Mendelian Randomization

Journal of Pain Research, Год журнала: 2025, Номер Volume 18, С. 2269 - 2283

Опубликована: Май 1, 2025

The relationship between adipose-muscle distribution and its effect on migraine remains unclear. This study examines the association muscle mass prevalence evaluates potential mediation by systemic inflammatory biomarkers. Using a cross-sectional design, we analyzed data from 10,400 participants in National Health Nutrition Examination Survey (NHANES) (1999-2004). appendicular lean normalized to body index (ALM/BMI) was evaluated through weighted logistic regression subgroup analyses. Mediation analyses were conducted examine mediating roles of markers, including C-reactive protein (CRP), white blood cell count (WBC), neutrophils, ALM/BMI prevalence. Genetic causality investigated via two-sample Mendelian randomization (MR) using genome-wide (GWAS) data. 20% total reported migraines. A higher ratio inversely associated with after full adjustment (OR = 0.243; 95% CI: 0.122-0.487, p < 0.001). Vigorous activity reduced susceptibility 24% 0.760; 0.663-0.872, CRP, WBC neutrophils mediated 2.0% (p 0.024), 3.1% 0.011), 2.8% 0.019) ALM/BMI-migraine association, respectively. inverse-variance approach (IVW) MR analysis indicated that basal metabolic rate (BMR) risk 0.996, 0.992-0.998, 0.004) headache 0.998, 0.997-1.000, 0.018). Fat-free also exhibited protective effects migraines 0.997, 0.994-1.000, 0.045). Increased is risk, partially attenuating inflammation. These findings provide us an health management prevent

Язык: Английский

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The Asia–Oceania consensus: Definitions and diagnostic criteria for sarcopenic obesity

Obesity Research & Clinical Practice, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

The aim of this study was to develop consensus definitions and diagnostic criteria for sarcopenic obesity tailored Asia-Oceania populations, a condition characterized by reduced skeletal muscle mass function with excess adipose tissue. Experts from various fields formed working group under the Association Study Obesity (AOASO) International Gerontology Geriatrics Asia/Oceania Region (IAGG-AOR). convened four meetings, employing Delphi technique achieve on management strategies obesity. defines 3-step algorithm, including screening, diagnosis, intervention. screening included BMI waist circumference calf circumference, SARC-F, Finger Ring test sarcopenia. sarcopenia include assessments (using dual-energy X-ray absorptiometry or bioelectrical impedance analysis), strength (handgrip strength), physical performance (gait speed, Short Physical Performance Battery, 5-Times Sit-to-Stand Test). Central is main concern diagnosis recommends combination dietary consultations, increased activity, resistance training, potential use oral nutritional supplements medications managing primary objective increase reduce tissue mass. established facilitate early recognition obesity, highlighting need interventions. Future research should focus long-term outcomes these interventions development pharmacological treatments.

Язык: Английский

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Adipositas in der Intensivmedizin

DMW - Deutsche Medizinische Wochenschrift, Год журнала: 2025, Номер 150(11), С. 632 - 644

Опубликована: Май 1, 2025

The prevalence of obesity and its associated comorbidities are increasing worldwide, leading to a rising proportion obese patients in hospitals intensive care units. This trend is causing significant additional burden on our healthcare system. An patient requiring treatment presents major challenges for the entire team, not only terms economic aspects but also medically, nursing care, physiotherapy. Additionally, psychosocial organizational factors play role that must be considered. For physiotherapy, appropriate aids such as lifters, special large hospital beds, suitable rooms, adequate staffing should provided. medical include intubation airway management, hemodynamic monitoring, vascular access, nutrition, dosing medication, difficult ultrasound conditions at bedside. Furthermore, this population has an increased risk developing pressure ulcers, pneumonia, thrombosis, which increase overall requirements further challenge setting.

Язык: Английский

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